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BIO 435 BIO 435

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(1)

BIO 435 BIO 435

ENZYMOLOGY ENZYMOLOGY

VI. WEEK

(2)

Enzyme

Kinetics

(3)

1. Enzymes affect reaction

rates, not equilibria

(4)

2. Reaction rates and equilibria

have precise thermodynamic

definitions

(5)

Substrate concentration affects the rate of enzyme-catalyzed

reactions.

(6)

Hyperbolic curves EQUATION

Sigmoidal feature

Michaelis-Menten Equation Michaelis-Menten Kinet

Michaelis-Menten Kinet ics ics

(7)

Michaelis-Menten Kinet

Michaelis-Menten Kinet ics ics

E + S k1 ES E + P

k-1

k2

E: enzyme

S: substrate

ES: Enzyme-Substrat komplex

P: product

(8)

Step 1:

Step 1:

Formation and

degradation of

the ES complex

(9)

Step 2:

Step 2:

Steady state

assumption

(10)

Step 3:

Step 3:

Solution of the

equation for ES

(11)

Step 4:

Step 4:

Vo EXPRESSION in

terms of ES

(12)

Referanslar

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