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BIO 435 BIO 435

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BIO 435 BIO 435

ENZYMOLOGY ENZYMOLOGY

X. WEEK

(2)

ENZYME

INHIBITION

(3)

ALLOSTERIC ALLOSTERIC

INHIBITION

INHIBITION

(4)

ALLOSTERIC ENZYME ALLOSTERIC ENZYME

ENZYMES IN THE ORGANIZATION OF

METABOLISM

(5)

Allosteric enzymes

Allosteric enzymes exist in either exist in either an active or inactive state.

an active or inactive state.

-possess an

-possess an allosteric site allosteric site where where

molecules other than the substrate

molecules other than the substrate

bind bind

(6)

FEED-BACK INHIBITION FEED-BACK INHIBITION

allosteric inhibitor of enzyme 1

A B C D E F G

enzyme

1

enzyme

2

enzyme

3

enzyme

4

enzyme

5

enzyme

6

X

(7)

 Example

◦ synthesis of amino acid, isoleucine

from amino acid, threonine

(8)

◦ isoleucine becomes the

allosteric inhibitor of the first

step in the pathway

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