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BIO 435 BIO 435

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BIO 435 BIO 435

ENZYMOLOGY ENZYMOLOGY

V. WEEK

(2)

ENZYMATIC CATALYST

MECHANISMS

(3)

BINDING ENERGY MAKES

CONTRIBUTION TO FREEDOM AND CATALYST…

(4)

SPECIFIC CATALITIC GROUPS CAN BE

ATTENDED TO CATALYST.

(5)

When the substrate is bound to the enzyme, catalytic functional groups contribute to the cleavage

and formation of the bond by a group of mechanisms…

(6)

Mechanisms Mechanisms

general acid-base catalysis

covalent catalysis

metal ion catalysis

(7)

GGeneral acid-base eneral acid-base catalysis

catalysis

FUNCTIONAL GROUPS IN THE

ACTIVE REGION OF ENZYMES MAY HAVE POTENTIAL TO TRANSFER

WITH AN ELECTRON / PROTON.

(8)

CCovalent catalysisovalent catalysis

SOME OF THE ENZYMES CAN CREATE COVALENT

INTERACTIONS WITHOUT SUBSTRATE.

(9)

MMetal ion catalysisetal ion catalysis

WEAK-LINKED INTERACTIONS BETWEEN METAL AND

SUBSTRATE

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