• Sonuç bulunamadı

ADHESION MOLECULES

N/A
N/A
Info
İndir
Protected

Academic year: 2021

Share "ADHESION MOLECULES"

Copied!
8
0
0

Yükleniyor.... (view fulltext now)

Şimdi indir ( 8 sayfa )

Tam metin

(1)

BIO 480

ADHESION

MOLECULES

(2)

INTEGRINS

(3)

play a role in cell-cell and

cell-extracellular matrix

interaction

(4)

cell surface molecule with heterodimeric structure

on different cells.

(5)

• Polypeptide chains:

extracellular +

transmembranous + cytoplasmic parts

have the ability to bind to molecules with Arginine-Glycine- Asparagine (RGD) sequence…

(6)

RGD

• extracellular matrix glycoproteins

• Fibronectin

• Vitronectin

• Laminin

• Fibrinogen

• most types of collagen

• complement components

• C3• C4

(7)

The integration of integrin group

adhesion molecules with their ligands leads to the reshaping of the

intracellular skeleton.

cell movement

(8)

• 3 integrin subclasses are defined according to the type of beta chain forming the heterodimer.

Beta2 integrins Beta1 integrins Beta3 integrins

Referanslar

Şimdi indir ( PPT - 8 sayfa - 127.50 KB )

Benzer Belgeler

ADHESION MOLECULES

• Structure, function and classification of adhesion molecules, adhesion molecules of immunoglobulin super family, integrins, selectins, mucin-like adhesion molecules,

ADHESION MOLECULES

Adhesion molecules belonging to the immunoglobulin family generally. function in

ADHESION MOLECULES

• The major ligand of the selectins are sialyl Lewis X (sLEx) and sialyl Lewis A, found on CD15 and some other cell surface molecules.... • Major members of the Selectin

ADHESION MOLECULES

Cadherins are involved in calcium- dependent cell-cell adhesion2. The molecule of a Cadherin binds to the molecule of similar

ADHESION MOLECULES

• Cytokines such as IL-1 and TNF, endotoxins, active macrophage products, C3a, C5a, histamine, LTC4 and thrombin trigger endothelial activation... • Selectins are

ADHESION MOLECULES

• Endothelium has a heterogeneous structure that shows morphological and physiological differences according to the function properties of organs and vascular

ADHESION MOLECULES

- regulation of cellular functions by activating intracellular signaling pathways controlling the cell growth, proliferation, and gene expression.. • ECM consists of two

ADHESION MOLECULES

• Binding of Grb2 to FAK and combine with SOS with the Focal adhesion kinase (FAK) adapter protein phosphorylated by Scr. • Stimulation by