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ADHESION MOLECULES

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(1)

BIO 480

ADHESION

MOLECULES

(2)

The Importance of Cell Adhesion

(3)

• living organisms to function normally

• keeping the tissues together

• function of migrating cells like white blood cells

• morphogenesis in fetal development

(4)

Measurement of

Cell Adhesion Molecules

• flow cytometry

• ELISA

• RT-PCR

• Hybridization

(5)

Adhesion Molecules and Cell Skeleton Interactions

• Protection of the basic cell structure

• Transport of cell-cell and cell-extracellular matrix signals to the nucleus

• Mechanical support for tissue integrity

• Participating in cell mobility events

(6)

Integrin-Extracellular matrix (ECM) interaction

• Extracellular matrix

- organize cells into tissue

- regulation of cellular functions by activating intracellular signaling pathways controlling the cell growth, proliferation, and gene expression

(7)

• ECM consists of two basic forms.

Interstitial matrix Fibrillar collagen Elastin

Proteoglycans and hyaluronan Basal membrane

Type IV collagen Laminin

proteoglycan

(8)

Both epithelial and mesenchymal cells (eg fibroblasts) interact

with ECM via integrins.

Integrin-ECM interaction uses the same intracellular signaling pathway

using growth factor receptors

Referanslar

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