ADHESION MOLECULES

(1)

BIO 480

(2)

Focal Adhesions and Signal Transduction

(3)

• Focal adhesions are structures in which a

large number of proteins come together and form.

• * allows the cell to attach to the extracellular matrix

• * plays a role in the transmission of signals by exchanging protein

(4)

• integrins standing together in groups

• cytoplasmic proteins

• actin filaments

(5)

• Interaction of extracellular material and integrins,

• Activation of cytoplasmic protein kinases, including Scr

• Binding of Grb2 to FAK and combine with SOS with the Focal adhesion kinase (FAK) adapter protein phosphorylated by Scr

• Stimulation by MAP kinase

• Active forms of PI3K and PKB

(6)

• Signals Related to Initiation of Focal Adhesions Focal adhesions:

actin filaments of the cytoskeleton, cytosolic proteins,

plasma membrane proteins extracellular components

(7)

• Collection of a focal adhesion is initiated from a key GTP-linked integrin called Rho.

• RhoA

• RhoB

• RhoC

(8)

• lipid kinase (phosphatidylinositol 5-kinase)

• phosphatidyl 4-phosphate inositol

• phosphotidyl 4,5-bisphosphate (PIP2)

• various actin binding proteins, such as profilin, gelsolin

(9)

Inactivation of myosin phosphatase results in activation of myosin