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ADHESION MOLECULES

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Tam metin

(1)

BIO 480

ADHESION

MOLECULES

(2)

IMMUNOGLOBULIN SUPER FAMILY

(3)

• Immunoglobulin (Ig) domain

• plasma membrane protein extracellular,

transmembranous and intracytoplasmic

(4)

Many molecules that play a direct or indirect role in the recognition of the

antigen of the immune system are

members of this family.

(5)

• Immunoglobulins

T lymphocyte receptor (TCR)

Class I and II major histocompatibility complex antigens (MHC class I and II)

CD2

LFA-2 (Lymphocyte function associated molecule-2) LFA-3

CD4 and CD8

(6)

• Intercellular adhesion molecule-1 (ICAM-1, CD54)

• ICAM-2 (CD102) and ICAM-3 (CD50)

• Vascular cell adhesion molecule-1 (VCAM-1)

(7)

• Neural cell adhesion molecule (NCAM)

• Platelet-derived growth factor receptor (PDGFR)

• Mucosal adressin MadCAM-1

(8)

Adhesion molecules belonging to the immunoglobulin family generally

function in cell-cell interactions.

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