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ADHESION MOLECULES

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(1)

BIO 480

ADHESION

MOLECULES

(2)

Selectins

(3)

leukocyte-endothelium and platelet endothelium adhesion

The early stage of the inflammatory response

(4)

• The selectins bind to the carbohydrate part of glycoproteins present on the surface of other cells with lectin tips.

• This attachment is a calcium dependent event.

• The major ligand of the selectins are sialyl Lewis X (sLEx) and sialyl Lewis A, found on CD15 and some other cell surface molecules.

(5)

• Major members of the Selectin family L-selectin

P-selectin E-selectin

(6)

L-selectins

found on the surface of some

lymphocytes, neutrophils, monocytes and other myeloid cells.

(7)

E-selectins

connect to sLEX sugars associated with surface glycoproteins such as CD15 on the surface of monocytes,

macrophages and granulocyte

allow the leukocytes to loosely attach to the endothelium

(8)

P-selectins

found in the membrane of dense

granules in platelets and in the Weibel- Palade bodies in endothelial cells.

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