BIO 480
ADHESION
MOLECULES
ADHESION MOLECULES IN INFLAMMATION
• Post-capillary venular endothelium in the region of inflammation is activated due to inflammation.
• Cytokines such as IL-1 and TNF, endotoxins, active macrophage products, C3a, C5a, histamine, LTC4 and thrombin trigger endothelial activation.
• Tethering: E and P selectin
• Signaling: LFA-1 and Mac-1 integrin molecules
• LFA-1 (CD11a / CD18), MaC 1 (CD11b / CD18) expressed on the leukocyte surface and activated integrins such as VLA-4 with the ligands of the immunoglobulin superfamily on the endothelial surface (ICAM-1 and 2, ICAM-1 and VCAM- 1) create a tight adhesion that can withstand the separating forces in the vein.
• Selectins are the early stages of neutrophil migration, and the later stages are organized and executed by integrins and adhesion
molecules belonging to the immunoglobulin superfamily.
• CD4+
• CD8+
• CD2
• LFA-1
• VLA
• 4 groups of adressins
-Peripheral lymph node adressins (PNAd),
-Mucosal lymph node adressins (Mad) such as
Peyer's plaques and appendix, synovium and skin adressins
-Peripheral lymph node adressins GlyCAM-1
CD34
-Mucosal adressin MAdCAM-1
