BIO-309
BIOCHEMISTRY I
XI. WEEK
•Pentose Phosphate Pathway :
•The phosphogylonate pathway, which is the other way of
glucose oxidation; oxidative
and non-oxidative; aim of this pathway and its connection
with oxidative stress
LECTURE CONTENTS OF LECTURE CONTENTS OF
11th WEEK
11th WEEK
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•The relationship between this path and glycolytic path,
•Products formed on the road and applications
•
•Controls
•In most animal tissues,
glucose is destroyed in the
path of energy until pyruvate.
Glucose 6-phosphate may be incorporated in many ways
according to the needs in the cells. In some tissues, NADPH is formed when glucose is
converted to 6-phosphate
pentose phosphates.
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• This pathway is called the
pentose phosphate pathway,
the phosphogluconate pathway or the hexose monophosphate pathway.
• Bu yol, hızla bölünen hücreler (kemik iliği, cilt barsak
mukozası ve tümörler gibi),
pentoz 5-fosfatı,
•In this pathway, rapidly
dividing cells (such as bone marrow, skin intestinal
mucosa and tumors) use the
pentose 5-phosphate structure of RNA, DNA, ATP, NADH,
FADH2 and coenzymes such
as coenzyme A.
• The other product of this path, NADPH, is used in fatty acid
synthesizing tissues such as liver, adipose tissue and the mammary gland in the
breastfeeding period. Adrenal glands, gonads and liver tissues that perform the synthesis of
active cholesterol and steroid
hormones, are also use this path.
• This route is also used in cells that are directly exposed to
oxygen, such as erythrocytes, corneal cells, eye lenses, or in free radical damage forms.
• The results of the genetic
deficiency of the first enzyme of
this pathway, namely glucose 6-
phosphate dehydrogenase, are
also very important.
•The pentose phosphate
pathway takes place in two
stages. In the oxidative phase, NADPH works by reducing
glutathione to GSSG.
•Two different
monosaccharides are formed in total 10 different carbon
numbers during the non- oxidative phase with
transaldolase and
transketolase enzymes.
• For example; ribose 5-phosphate + xylose 5-phosphate or
sedoheptilose 7-phosphate +
glyceraldehyde 3-phosphate
• DETAILED INFORMATION ON THIS SUBJECT WILL BE DISCUSSED
WITH BIOCHEMICAL FORMULAS, ENZYMATIC and TOTAL
REACTIONS
REFERENCES
MAIN :
Lehninger Principles of Biochemistry, DavidLehninger Principles of Biochemistry, David L. Nelson, Michael M. Cox, 5th Edition, 2013.L. Nelson, Michael M. Cox, 5th Edition, 2013.
Principles of Biochemistry, H. R. Horton, L. A.
Principles of Biochemistry, H. R. Horton, L. A.
Moran, K. G. Scrimgeour, M. D. Perry, J. D. Rawn, Moran, K. G. Scrimgeour, M. D. Perry, J. D. Rawn,
Pearson Prentis Hall, 2006.
Pearson Prentis Hall, 2006.
Color Atlas of Biochemistry, J. Koolman, K. H.
Color Atlas of Biochemistry, J. Koolman, K. H.
Roehm, Georg Thieme Verlag, 2005.
Roehm, Georg Thieme Verlag, 2005.
Harper’s Illustrated BiochemIstry, R. K. Murray, Harper’s Illustrated BiochemIstry, R. K. Murray, D. K. Granner, P. A. Mayes, V. W. Rodwell, Lange D. K. Granner, P. A. Mayes, V. W. Rodwell, Lange Medical Books/McGraw-Hill Medical PublishIng Medical Books/McGraw-Hill Medical PublishIng
DIvIsIon, 2003.
DIvIsIon, 2003.
Basic Concepts in Biochemistry, A Student’s Basic Concepts in Biochemistry, A Student’s Survival Guide, H. F. Gilbert, McGraw-Hill Health Survival Guide, H. F. Gilbert, McGraw-Hill Health
Proffesions Division, 2000 Proffesions Division, 2000.
