BIO-309
BIOCHEMISTRY I
II. WEEK
LECTURE CONTENTS OF SECOND WEEK
• To detailing the concept of stereoisomerism in order to understand and define the three-dimensional structure of molecules
• Biochemical importance of the subject will be
discussed in accordance with the students' knowledge
of organic chemistry.
• Bonds especially covalent bonds and functional groups are particularly important for the functions of biomolecules.
• In biochemistry, functional groups of molecules are important in determining their three-dimensional structures which means their location in space.
• Stereochemical properties of these carbon-containing
compounds are important for their function.
• Three-dimensional interactions of biomolecules determine their roles.
• Stereosensitivity is important in interactions between biomolecules.
• This part will be detailed in the course and various
examples will be given.
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%2Fokdn6%2Fokdn6.htm&psig=AOvVaw0-Fbt-
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https://www.google.com/url?sa=i&url=http%3A%2F%2Fbiyokimya.vet%2Fdocuments%2FOrganik-kimya
%2FC_Atomu_ve_Stereokimya.pdf&psig=AOvVaw0-Fbt-
Q1Pg5vRLwjAnqusb&ust=1589378645424000&source=images&cd=vfe&ved=0CAIQjRxqFwoTCMj1nIC_ruk CFQAAAAAdAAAAABA7
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%3DStereoizomerizm&psig=AOvVaw0-Fbt-
Q1Pg5vRLwjAnqusb&ust=1589378645424000&source=images&cd=vfe&ved=0CAIQjRxqFwoTCMj1nI C_rukCFQAAAAAdAAAAABBI
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%2520Ocak%25202020.pdf&psig=AOvVaw0-Fbt-
Q1Pg5vRLwjAnqusb&ust=1589378645424000&source=images&cd=vfe&ved=0CAIQjRxqFwoTC Mj1nIC_rukCFQAAAAAdAAAAABBX
• Stereochemical representation of simple molecules will be written three different types.
• The role of chiral centers will be discussed in the
regulation of bonds and substitution groups limiting the return of configuration.
• Examples of geometric and cis-trans isomers will be
given and biochemical differences will be detailed
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• The importance of molecular asymmetry, chiral and
achiral molecules, enantiomers and diastereomers in
biochemistry will be explained through formulas.
CHEMİCAL BONDS EFFECTİVE İN FORMATİON OF MACROMOLECULES :
• Intramolecular and intermolecular chemical bonds;
strong and weak bonds; disulfide bridges, hydrogen
bonds, hydrophobic relations etc. will DISCUSSED
• weak interactions in aqueous systems,
• Hydrogen bonding as an electrostatic attraction between the oxygen atom of a water molecule and the hydrogen atom of the other water molecule,
• Hydrophobic interactions that hold together
hydrophobic regions of molecules,
• Amphipathic compounds containing polar or charged and non-polar regions,
• The weak attraction forces (van der Waals interactions) formed with dipole when two uncharged atoms
approach each other,
• Ionic interactions between charged groups
• These are the topics to be discussed in his week.
• Questions will be asked at the end of the course and wanted to discuss for the following week.
• The questions asked in the previous week will be
evaluated.
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classification
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REFERENCES
MAIN : Lehninger Principles of Biochemistry, David
L. Nelson, Michael M. Cox, 5th Edition, 2013.
Principles of Biochemistry, H. R. Horton, L. A.
Moran, K. G. Scrimgeour, M. D. Perry, J. D. Rawn, Pearson Prentis Hall, 2006.
Color Atlas of Biochemistry, J. Koolman, K. H.
Roehm, Georg Thieme Verlag, 2005.
Harper’s Illustrated BiochemIstry, R. K. Murray, D. K. Granner, P. A. Mayes, V. W. Rodwell, Lange Medical Books/McGraw-Hill Medical PublishIng DIvIsIon, 2003.
Basic Concepts in Biochemistry, A Student’s Survival Guide, H. F. Gilbert, McGraw-Hill Health Proffesions Division, 2000.
