BIO-309
BIOCHEMISTRY I
VII. WEEK
• Continue to carbohydrates and glycobiology subjetcs
• Polysaccharides and
glucoconjugates will be the content of this course.
LECTURE CONTENTS OF LECTURE CONTENTS OF
7th WEEK
7th WEEK
• Biochemical structures of starch, glycogen, chitin,
cellulose and dextrans will be
detailed
•Some examples of biochemical structures and functions of
heteropolysaccharides,
proteoglycan, glycoprotein and glycolipids in extracellular
matrix will be given.
•Polysaccharides are found in nature as high molecular
weight polymers, and these
molecules can also be termed as glycans according to their repeating units, chain
lengths, and depending on
their degree of branching.
https://www.google.com/url?sa=i&url=http%3A%2F%2Fbiology.reachingfordreams.com%2Fbiology
%2Fbiomolecules%2F25-3-types-of-
carbohydrates&psig=AOvVaw3qCMxpLnlnjGAFJ3wijl8S&ust=1589392328853000&source=images
&cd=vfe&ved=0CAIQjRxqFwoTCMin6_zxrukCFQAAAAAdAAAAABAS
•Polysaccharides can be divided into homo- and heteropolysaccharides.
•Some homosaccharides work as monosaccharides reservoir used like a fuel (eg starch
and glycogen)
•The storage conditions of carbohydrates will be
discussed.
•Information on energy
metabolism of mammalian
cells will be given.
•Some polysaccharides carry out structural functions.
•Cellulose, found in plant cell wall with its fibrous, tough and water-insoluble
properties, is one of them.
• The kitin is a homopolysaccharide derivative consisting of an N-
acetylglucosamine, and forms the skeleton of insects.
• Another structural polysaccharide is agar, which is a sulfated
heteropolysaccharide of L- and D- derivatives of ether-bound
galactose.
https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.quora.com%2FHow-are-cellulose-and-chitin- different&psig=AOvVaw2T7VzNvCVc1wHAmJhyGyQ-
&ust=1589392603181000&source=images&cd=vfe&ved=0CAIQjRxqFwoTCPDg_oLzrukCFQAAAAAdAAAA ABAS
https://www.google.com/url?sa=i&url=http%3A%2F%2Fcellulose.gatech.edu%2Fbackground- cellulose&psig=AOvVaw2T7VzNvCVc1wHAmJhyGyQ-
&ust=1589392603181000&source=images&cd=vfe&ved=0CAIQjRxqFwoTCPDg_oLzrukCFQAAAAAdA AAAABAY
• The intercellular place in the
tissues of multicellular animals is filled with extracellular
matrix, with its gelatinous structure that creates an
environment for diffusion of
oxygen and nutrients and also
helps to hold the cells together.
https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.slideshare.net
%2FNayeem141110%2Fcarbohydrate-
derivatives&psig=AOvVaw1LD89W0JJ3l66_xkIkiwmQ&ust=1589391955906000&sour ce=images&cd=vfe&ved=0CAIQjRxqFwoTCMjA1czwrukCFQAAAAAdAAAAABAD
• These heteropolysaccharides are polymers formed from repeating disaccharide units of
glycosaminoglycans.
• Repeating units of some
glycosaminoglycans of the
extracellular matrix: hyaluronan, chondriotin 4-sulfate, keratan
sulfate and heparin
https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.pinterest.ru%2Fpin
%2F483292603756903017%2F&psig=AOvVaw32tj3dgjEkBsjA_DyRGCps&ust=1589392842960000&source
=images&cd=vfe&ved=0CAIQjRxqFwoTCOi-svzzrukCFQAAAAAdAAAAABAG
• DETAILED INFORMATION ON THIS SUBJECT WILL BE DISCUSSED
WITH BIOCHEMICAL FORMULAS
REFERENCES
MAIN : Lehninger Principles of Biochemistry, David
L. Nelson, Michael M. Cox, 5th Edition, 2013.
Principles of Biochemistry, H. R. Horton, L. A.
Moran, K. G. Scrimgeour, M. D. Perry, J. D. Rawn, Pearson Prentis Hall, 2006.
Color Atlas of Biochemistry, J. Koolman, K. H.
Roehm, Georg Thieme Verlag, 2005.
Harper’s Illustrated BiochemIstry, R. K. Murray, D. K. Granner, P. A. Mayes, V. W. Rodwell, Lange Medical Books/McGraw-Hill Medical PublishIng DIvIsIon, 2003.
Basic Concepts in Biochemistry, A Student’s Survival Guide, H. F. Gilbert, McGraw-Hill Health Proffesions Division, 2000.
