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CELL RECEPTORS

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BIO 473

CELL RECEPTORS

5. WEEK

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Types of Receptors

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Membrane receptors

Most extracellular signal molecules bind to

specific membrane receptors.

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Membrane receptors

Two common strategies used to transfer signals

1.Conformational changes

2.Clustering

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A cells senses signals from its

surroundings via receptor proteins

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Major classes of surface (MEMBRAN) receptors for

signaling

1.Ion channel-linked receptors

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Major classes of surface (MEMBRAN) receptors for

signaling

2. G-protein linked receptors

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Major classes of surface (MEMBRAN) receptors for

signaling

3. Enzyme linked receptors

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Major classes of surface (MEMBRAN) receptors for

signaling

4. TNF family receptors

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Nuclear receptors

Ligand activated transcription factors…

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Nuclear receptors

Ligands:

Steroid hormones Lipid vitamins

Dietary lipids

Referanslar

Benzer Belgeler

Prof.Dr.Nuray Arı, 2018..

• Structural and functional properties of receptors and their classification, cell surface receptors, endocytotic pathway and intracellular movement, classification

• Signaling pathways often have a cascade architecture which result in strong signal amplification.... Signal transduction is the biochemical

Transport from signaling cell to target cell... Steps in

Signal molecule located on surface of signaling cells or on extracellular matrix.. Types of

Major classes of surface (MEMBRAN) receptors

• Transmembrane receptor pass through the cell membrane SEVEN TIMES…... Phosphatidylinositol

• The part of the receptor protein extending into the cytoplasm functions more specifically as a tyrosine kinase, an enzyme that catalyzes the transfer of a phosphate group from ATP