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kolinerjik receptors

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kolinerjik receptors

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Pentameric ligand-gated ion channel)s

General topology of pLGICs (Pentameric ligand-gated ion channels

)

The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions &

allosteric modulation. Neuropharmacology. 2015 Sep;96(Pt B):137-49. doi: 10.1016/j.neuropharm.2014.12.006. Epub 2014 Dec 18. Cecchini M,Changeux JP.

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nAChR Structure and function.

A: The nAChR as viewed from above shows five subunits arranged around a central cation-conducting pore. A

ligand-binding site is formed at the interface of two subunits. B: An illustration of a single nAChR subunit embedded in the membrane. C: The protein structure of the pentameric nAChR obtained from T. marmorata (PDB 2BG9) in the plasma membrane. Shown are the location and function of the major receptor domains A single subunit is highlighted in purple using visual molecular dynamics (VMD). Mutations in the membrane and intracellular regions of the human nAChR are shown

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