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CELL RECEPTORS

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(1)

BIO 473

CELL RECEPTORS

7. WEEK

(2)

Major classes of surface (MEMBRAN) receptors for

signaling

G-protein linked receptors

(3)

G-protein-coupled receptors

(GPCRs) are the largest and most diverse group of membrane

receptors in eukaryotes.

(4)

What are G protein?

• Heterotrimetric GTP binding proteins, composed of 3 subunits

1.Alpha 2.Beta

3.Gamma

(5)

G protein protein coupled receptor

• Transmembrane receptor pass through the cell membrane SEVEN TIMES….

(6)

Signal pathways

• 1. cAMP dependent pathway

• 2. Phosphatidylinositol signal pathway

(7)

G protein-coupled receptors requires: GTP

Receptor indirectly controls channel G protein-gated ion channels

2d messenger systems Neuromodulation

Effector: adenylate cyclase

Second messenger: cAMP

(8)

cAMP activates target enzyme

Protein Kinase A (PKA) phosphorylates

target proteins

A Signal Cascade Cascade amplification amplification

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