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CELL RECEPTORS

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BIO 473

CELL RECEPTORS

2. WEEK

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Cell Signaling

• Signaling pathways often have a cascade architecture which result in strong signal amplification.

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Signal transduction is the biochemical mechanism of

transmitting signals inside the cell

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Signaling pathways regulate early all cellular functions

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Processes regulated by cell-cell signaling

• Metabolism

• Cell growth and division

• Cell movement

• Differentiation

• Development

• Processing of sensory information

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Cellular response to signaling can be fast or slow….

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RECEPTORS

Receptor bind signaling molecules.

Receptors are sensitive ans specific

More than 1500 human gens encode receptors

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Signaling Ligands

Ligands that bind to cell-surface receptors:

1. Neurotransmitters (NT) 2. Peptide hormones (P) 3. Growth factors (GF)

4. Lipophilic signaling molecules

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Signaling Ligands

Ligands that bind to intracellular receptors:

Lipid soluble hormones

Referanslar

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