精胺酸添加對異種移植裸鼠大腸癌細胞生長之影響 胡雅梅 李正中 蔡佑靈 葉松鈴 台北醫學大學保健營養學系 本研究探討精胺酸 (Arginine, Arg)添加對異種移植裸鼠大腸癌細胞生長之影 響。實驗培養人類大腸直腸腺癌細胞株SW-480，以 25 號針頭注射針注入 100μl細 胞液 (1*106個細胞)於裸鼠背部右側皮下後隨機分成兩組，控制組 (Con組)給予不 含Arg之粉狀飼料，實驗組 (Arg組)給予富含Arg的粉狀飼料，兩組飼料以等氮量、 等熱量配製。經五週餵食後將裸鼠犧牲，取血、腫瘤細胞及脾臟分析。結果顯示 在實驗後期Arg組腫瘤體積顯著小於Con組；在腫瘤均質液中Arg組一氧化氮的濃度 顯著高於Con組，而促血管新生因子中Arg組血管內皮生長因子受器、基質金屬蛋 白酶-2、9 皆顯著低於Con組，此外Arg組其胰臟內自然殺手細胞數量顯著高於Con 組。故推測飲食中添加Arg可增加一氧化氮在體內的表現量及自然殺手細胞的數 量，並減少促血管新生因子的生成，因而抑制腫瘤細胞生長。 關鍵字：精胺酸、一氧化氮、促血管新生因子、自然殺手細胞
精胺酸添加對異種移植裸鼠大腸癌細胞生長之影響
1
0
0
Tam metin
Benzer Belgeler
On the other hand, L-Glu and it's subtypes including N-meghy1-D-aspartate (NMDA), kainic acid (KA) and quisqualic acid (QA), which functions to protect mucosal damage
On the other hand, L-Glu and it's subtypes including N-meghy1-D-aspartate (NMDA), kainic acid (KA) and q uisqualic acid (QA), which functions to protect mucosal damage
本研究探討於敗血症 (sepsis)時，由靜脈注射給予單一劑量麩醯胺 (glutamine, GLN)對敗血症所引起的器官損傷及存活率之影響。實驗將雄性 ICR
Mice were randomly assigned to 6 groups, 2 normal groups with or without GLN supplementation were provided with distilled water, 4 experimental groups were divided by 2 levels of
Mice were randomly assigned to 6 groups, 2 normal groups with or wit hout GLN supplementation were provided with distilled water, 4 experimental groups were divided by 2 le vels
cyte Function-associated antigen (LFA ) -1 及 macrophage antigen (Mac) –1 的表現。肝臟組織均質後離心，收 集上清液，分析 GSH (glutathione), GSSG (oxidize d
After four months, liver and serum trigl yceride, total cholesterol, LDL-C, HDL-C, free fatty acids were analyzed, l iver PPAR (peroxisome proliferator-activated receptor) delta,
Concentration of nitric oxide (NO) in tumor homogenate.* Significantly different from the control group.. control
