Abstracts S333 [5] Sowa-Ku´cma,M., Szewczyk,B.,Sadlik,K.,Piekoszewski, W.,
Trela,F.,Opoka,W.,Poleszak,E.,Pilc,A.,Nowak,G.,2013. Zinc, magnesium and NMDA receptor alterations in the hip-pocampusofsuicidevictims.JAffectDisord151,924–931. doi:10.1016/j.euroneuro.2018.11.520
P.505Evaluationofsuicideattemptbyusingmedicines andchemicals
G.Kavak∗
selcuk universty, department of psychiatry, Konya, Turkey Background: AccordingtodatafromtheWorldHealth Or-ganization,about800000peopledieduetothesuicide at-tempt in each year, and the rate of uncompleted suicide is 10to40foldhigherthanthisnumber[1].Suicideis the second most frequent cause of deathamongpeople aged between15-29 years,and1inevery40secondsan individ-ualdiefromsuicide[2].Withthisbackground,weaimedto evaluatethe patientswhoadmittedtotheemergency de-partmentafterasuicideattemptinthelastyear.
Methods:Socio-demographicinformationofindividuals ad-mittedtotheemergencydepartmentbetween 01.01.2017-31.12.2017 were evaluated. History of illness, types of chemicals andmedicine usedfor suicideattempt, rateof psychiatric consultation request, and psychiatric recom-mendationswerescreenedfromhospitalrecords.
Results: Of the 146 patients included in the study,69.2% werewomen(n:101),30.8%weremen(n:45)andthemean agewas27.8± 11.9years(min.16max.73).Therateofthe firstsuicideattemptwas97.3%(n:142).Morethanhalfof theindividuals(59.6%)hadattemptedsuicidebytaking non-psychiatric drugs while 17.8% of themhad attempted sui-cidewithpsychiatricdrugs(n:26).Afterpsychiatric evalua-tionoftheremaining,onethird(33.6%)ofthemwasoffered for outpatient unit control with a psychiatric treatment, while 37.7%wasdischargedfor psychiatricoutpatientunit visitinaweekwithoutanypharmacologicaltreatment rec-ommendation andthreepatients(2.1%)werehospitalized. Itwasdeterminedthat43.2%(n:63)ofthepatientshada previouspsychiatricdiagnosis.Distributionofdiagnosiswas, 18.9% wasdiagnosedwithdepressiveepisode(n: 28),4.1% wasdiagnosedwithapersonalitydisorder(n:6)and remain-ingsubjectswerediagnosedwithachronicpsychiatric dis-ease(bipolardisorder;3.4%,psychoticdisorders;1.4).When wescreenedtheoutpatientvisitsofthesubjectsafter sui-cideattempt,wefoundthatapproximatelyonequarterof thepatientscametothecontrolvisit.Onefive(20.6%)ofthe patients came tothe outpatientclinic control in the first week, 23.5% inthe firstmonth and2.9%in 6months after thesuicideattempt.Ofthepatientswhocametothe con-trolvisit,41.2%wasonapsychiatricpharmacological treat-ment,32.4%wasprescribedanantidepressantand5.9%was treatedonlywithcognitivebehavioraltherapy.
Conclusion: AccordingtothedatafromTurkishStatistical Institute, suicidewithdrugs andchemicals (6.3%)wasthe fourth most frequent suicidemethodafterfirearms, jump-ingfromheightandhangingamongcompletedsuicides[3]. Ourdatawasconsistentwiththenationalandinternational
datathat depressiveepisodewasthe mostfrequent diag-nosisinoursample.Andpersonalitydisordersarealso im-portantconditionsthatwe commonlyencounterwith self-destructive behaviours. We believe that it will be useful toconsidereach suicideattemptin coordinationwiththe emergencydepartment,todevelopagoodregistration sys-temandtoco-ordinatetreatmentandmanagement guide-linesfortheintervention
References
[1]WorldHealth Organization,2014.PreventingSuicideaGlobal Imperative. Global epidemiology of suicide and suicide at-tempts7(1),21.
[2]Öncü,B.,2017.Suicidalbehaviourepidemiologyandrisk fac-tors.CurrentApproachesinPsychiatry7(1),3–4.
[3]Öncü, B.,2016. Suicide and risk factors forsuicide. Turkiye KlinikleriJPsychiatrySpecialTopics9(3),1–15.
doi:10.1016/j.euroneuro.2018.11.521
P.506 Impact of sleep quality on cognitive perfor-mance and heterogeneity of depression in patients withmajordepressivedisorder(MDD)
E.Berdzenishvili1,∗,M.Okruashvili2,M.Roinishvili3, T.Gamyrelidze2,E.Chkonia1
1Tbilisi State Medical University, Department of Psychiatry, Tbilisi, Georgia
2Tbilisi Mental Health Centre, Department of Psychiatry, Tbilisi, Georgia
3Institute of Physiology, Department of Neurocognitive Studies, Tbilisi, Georgia
Introduction:PersonswithMajorDepressiveDisorder(MDD) show impaired performance onmeasures of frontotempo-rallymediatedcognitivefunction,includingexecutive func-tioning,attention andworking memory[1].Research sug-gests that MDD patients withneurocognitive deficitstend tobelessresponsivetoantidepressanttreatment[2].Sleep isessentialforcognitiveperformance.Peoplewhoare ex-posedtosleeplossusuallyexperienceadeclineincognitive performanceandexperiencechangesinthemood[3].Sleep disturbancesvaryamongpatientswithMDD,givingthe sub-stantial clinicalheterogeneity ofdepression [4].The clas-sification of patients according to their symptom profiles andatthesametimeincorporatingotherdimensionsof de-pressionsuchasobjectivemeasuresofneurocognitive func-tioning,maybehelpfulindeterminingdepressionsubtypes, whatseemstobeapotentpredictorfortreatmentresponse [5].
Aim: Here we investigate association of subjective sleep qualityandobjectivemeasures ofneurocognitive dysfunc-tioninpatientswithMDD.Wehypothesizedthatpoorsleep qualityamongpersonswithMDDwouldbeassociatedwith lowerscoresonobjectivemeasuresoffrontotemporally me-diated neurocognitive functions and may be discussed as subtypeofdepression
Methods:Twogroupsofpatients,whometDSMVdiagnostic criteriaofrecurrentMDD,wereselectedandmatched ac-cordingtodemographicdata.Onegroup(24patients,mean
