Bu çalışmada aromatik kumarin tiyazol Schiff Bazları ve onların Pd(II), Pt(II) kompleksleri sentezlenmiştir. Sentezlenen kumarin tiyazol hibrit moleküllerinin anyon duyarlılık çalışmaları yapılmış ve kemosensör olma potansiyelleri araştırılmıştır. Ayrıca tüm bileşiklerin çeşitli kanser hücreleri (MCF-7;insan göğüs kanseri, LS174T; insan kolon kanseri ve LNCAP; insan prostat kanseri) üzerinde antikanser aktiviteleri araştırılmıştır.
1- Çalışmadan elde ettiğimiz sonuçlara göre; sentezlenen yeni aromatik kumarin tiyazol türevleri ve Pd (II), Pt (II) komplekslerinin in vitro antitümör aktiviteye sahip olduğu görülmektedir. Bu maddelerin in vivo denemelerde nasıl sonuçlar vereceği, sağlıklı dokular üzerine etkilerinin neler olacağının araştırılması oldukça önemlidir. Bu kapsamda etki mekanizmalarına yönelik farklı deney protokollerinin hazırlanması ve araştırmaların yapılmasına ihtiyaç duyulmaktadır. karşılaşılmaktadır. CN- anyonuna karşı yüksek hassasiyet gösteren O-vantk ligandının kolay kullanılabilir bir algılayıcı prob olarak geliştirilebilmesi mümkün gözükmektedir.
Bu yüzden bu ligantın CN- anyonuna karşı seçiciliğini desteklemek için elektro kimyasal yöntemle incelenmesi düşünülmektedir.
3- Literature göre kumarin tiyazol türevlerinin asetilkolinesteraz enzimi üzerine inhibisyon etkisinin olduğu bilinmektedir [110]. Bu amaçla 3-terbutsalk ligandı in vivo çalışmalarda asetilkolinesteraz enzimi üzerinde inhibisyonunu incelemek üzere bu konuda çalışmalar yürüten Slovakya Üniversitesinde mikrobiyoloji uzmanlarına gönderilmiştir.
4- Literature göre kumarin tiyazol türevlerinin pestisit üzerinde çalışmaları mevcuttur [111]. Bu amaçla 3-terbutsaltk ligandı Akdeniz üniversitesi ziraat fakültesi uzmanlarınca incelenmek üzere gönderilmiştir.
5- Tüm bu yapılan çalışmalar, ligand ve komplekslerin çok yönlülüğünü ve başarılı sonuçlarını ortaya koymaktadır. Çalışmaların ilerletilmesi sonucu eczacılık, endüstri ve
çevre üzerine etkili yeni bir ürün ortaya çıkma potansiyeli yüksek olduğu öngörülmektedir.
KAYNAKLAR
1. İnternet:Kumarin tanımı, URL: http://www.webcitation.org/6dbkJQZX9, Son Erişim Tarihi:07.12.2015
2. İnternet: Kumarin tanımı, URL: http://www.webcitation.org/6dbkJQZX9, Son Erişim Tarihi:07.12.2015
7. Geddes, C. D. (2001). Optical halide sensing using fluorescence quenching: theory, simulations and applications-a review. Measurement Science and Technology, 12(9), R53.
8. Rethmeier, J., Rabenstein, A., Langer, M., Fischer, U. (1997). Detection of traces of oxidized and reduced sulfur compounds in small samples by combination of different high-performance liquid chromatography methods. Journal of chromatography A, 760(2), 295-302.
9. Li, H., Cai, L., Chen, Z. (2012). Coumarin-derived fluorescent chemosensors.
INTECH Open Access Publisher.
10. Wagner, B. D. (2009). The use of coumarins as environmentally-sensitive fluorescent probes of heterogeneous inclusion systems. Molecules, 14(1), 210-237.
11. Christie, R. M. (1993). Fluorescent dyes. Review of Progress in Coloration and Related Topics, 23(1), 1-18.
12. Jones, G. , Jackson, W. R. , Choi, C. Y., Bergmark, W. R. (1985). Solvent effects on emission yield and lifetime for coumarin laser dyes. Requirements for a rotatory decay mechanism. The Journal of Physical Chemistry, 89(2), 294-300.
13. Jones, G., Jimenez, J. A. C. (2001). Azole-linked coumarin dyes as fluorescence probes of domain-forming polymers. Journal of Photochemistry and Photobiology B:
Biology, 65(1), 5-12.
14. El-Kemary, M., Rettig, W. (2003). Multiple emission in coumarins with heterocyclic substituents. Physical Chemistry Chemical Physics, 5(23), 5221-5228.
15. Duke, R. M., Veale, E. B., Pfeffer, F. M., Kruger, P. E., Gunnlaugsson, T. (2010).
Colorimetric and fluorescent anion sensors: an overview of recent developments in the use of 1, 8-naphthalimide-based chemosensors. Chemical society reviews, 39(10), 3936-3953.
16. Cametti, M., Rissanen, K. (2009). Recognition and sensing of fluoride anion.
Chemical Communications, (20), 2809-2829.
17. Gale, P. A., Caltagirone, C. (2015). Anion sensing by small molecules and molecular ensembles. Chemical Society Reviews.
18. Zheng, X., Zhu, W., Liu, D., Ai, H., Huang, Y., Lu, Z. (2014). Highly selective colorimetric/fluorometric dual-channel fluoride ion probe, and its capability of differentiating cancer cells. ACS applied materials & interfaces, 6(11), 7996-8000.
19. Zhao, J., Ji, S., Chen, Y., Guo, H., Yang, P. (2012). Excited state intramolecular proton transfer (ESIPT): from principal photophysics to the development of new chromophores and applications in fluorescent molecular probes and luminescent materials. Physical Chemistry Chemical Physics, 14(25), 8803-8817.
20. Cametti, M., Rissanen, K. (2009). Recognition and sensing of fluoride anion.
Chemical Communications, (20), 2809-2829.
21. Rihn, S., Retailleau, P., De Nicola, A., Ulrich, G., & Ziessel, R. (2012). Synthetic routes to fluorescent dyes exhibiting large Stokes shifts. The Journal of organic chemistry, 77(20), 8851-8863.
22. Phukan, S., Saha, M., Pal, A. K., Bhasikuttan, A. C., Mitra, S. (2015). Intramolecular charge transfer in coumarin based donor-acceptor systems: Formation of a new product through planar intermediate. Journal of Photochemistry and Photobiology A:
Chemistry, 303, 67-79.
23. Amarasekara, A. S., Owereh, O. S., Lyssenko, K. A., Timofeeva, T. V. (2009).
Structural tautomerism of 4-acylpyrazolone schiff bases and crystal structure of 5-methyl-2-phenyl-4-{1-[(pyridin-2-ylmethyl)-amino]-ethylidene}-2, 4-dihydro-pyrazol-3-one. Journal of Structural Chemistry, 50(6), 1159-1165.
24. Holzer, W., Hahn, K., Brehmer, T., Claramunt, R. M., Pérez‐Torralba, M. (2003). The Structure of 4‐Benzoyl‐5‐methyl‐2‐phenylpyrazol‐3‐one Oxime and Its Methyl Derivatives. European Journal of Organic Chemistry, 2003(7), 1209-1219.
25. ALKIS M. (2015) Kumarin-Pirazol-Triazin Halkası İçeren Floresans Melez Moleküllerin Sentezi, Fotofiziksel Özellikleri Ve Anyon Algılayıcısı Olarak Kullanılma Potansiyelinin Araştırılması, Yüksek Lisans Tezi Kimya Anabilim Dalı Gazi Üniversitesi Fen Bilimleri Enstitüsü.
26. Li, H., Cai, L., Chen, Z. (2012). Coumarin-derived fluorescent chemosensors.
INTECH Open Access Publisher.
27. Jones, G., Rahman, M. A. (1994). Fluorescence properties of coumarin laser dyes in aqueous polymer media. Chromophore isolation in poly (methacrylic acid) hypercoils.
The Journal of Physical Chemistry, 98(49), 13028-13037.
28. Yu, C., Luo, M., Zeng, F., Wu, S. (2012). A fast-responding fluorescent turn-on sensor for sensitive and selective detection of sulfite anions. Analytical Methods, 4(9), 2638-2640.
29. Yang, Y., Huo, F., Zhang, J., Xie, Z., Chao, J., Yin, C., ... & Yan, X. (2012). A novel coumarin-based fluorescent probe for selective detection of bissulfite anions in water and sugar samples. Sensors and Actuators B: Chemical, 166, 665-670..
30. Gunnlaugsson, T., Glynn, M., Tocci, G. M., Kruger, P. E., Pfeffer, F. M. (2006).
Anion recognition and sensing in organic and aqueous media using luminescent and colorimetric sensors. Coordination chemistry reviews, 250(23), 3094-3117.
31. Kim, G. J., & Kim, H. J. (2010). Coumarinyl aldehyde as a Michael acceptor type of colorimetric and fluorescent probe for cyanide in water. Tetrahedron Letters, 51(21), 2914-2916.
32. Engblom, S. O. (1998). The phosphate sensor. Biosensors and Bioelectronics, 13(9), 981-994.
33. Huang, W., Chen, Z., Lin, H., Lin, H. (2011). A novel thiourea–hydrazone-based switch-on fluorescent chemosensor for acetate. Journal of Luminescence, 131(4), 592-596.
34. Shao, J., Lin, H., Yu, M., Cai, Z., Lin, H. (2008). Study on acetate ion recognition and sensing in aqueous media using a novel and simple colorimetric sensor and its analytical application. Talanta, 75(2), 551-555.
35. DEMER, S. A., MEMİŞ, Ü. (2011). Isparta İl Merkezinde İçme Sularının Farklı Florür İçeriklerinin İncelenmesi. Ekoloji, 20(79), 77-82.
36. Altundağ, H., Yüceel, Ç., Dündar, M. Ş., & Albayrak, S. (2011). Sakarya İli İçme Sularında Flor Düzeylerinin İyon Seçici Elektrod ve İyon Kromotografisi İle Tayini.
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 15(2).
37. Demirel Ü.(2009). "Flor Elementinin Canlılar Üzerine Etkisi ve Kapadokya Bölgesinde Florosis Gerçeği", 1.Tıbbi Jeoloji Çalıştayı, Ürgüp Bld., Kültür Merkezi, Ürgüp/ NEVŞEHİR
38. İnternet: T. C. Sağlık Bakanlığı "İnsani Tüketim Amaçlı Sular Hakkında Yönetmelik".
URL:http://www.webcitation.org/query?url=http%3A%2F%2Fsaglik.gov.tr%2FTR
%2Fbelge%2F1-569%2Finsani-tuketim-amacli-sular-hakkinda-yonetmelik.html&date=2015-12-07
amaclisularhakkinda+yonetmelik.com&date=2015-12-07
39. Graefe, A., Stanca, S. E., Nietzsche, S., Kubicova, L., Beckert, R., Biskup, C., &
Mohr, G. J. (2008). Development and critical evaluation of fluorescent chloride nanosensors. Analytical chemistry, 80(17), 6526-6531.
40. Liao, J., Sihler, H., Huey, L. G., Neuman, J. A., Tanner, D. J., Friess, U., . Ullmann, K. (2011). A comparison of Arctic BrO measurements by chemical ionization mass spectrometry and long path‐differential optical absorption spectroscopy. Journal of Geophysical Research: Atmospheres (1984–2012), 116(D14).
41. Ma, B., Zeng, F., Zheng, F., Wu, S. (2011). A Fluorescence Turn‐on Sensor for Iodide Based on a Thymine–HgII–Thymine Complex. Chemistry-A European Journal, 17(52), 14844-14850.
42. Haldimann, M., Zimmerli, B., Als, C., Gerber, H. (1998). Direct determination of urinary iodine by inductively coupled plasma mass spectrometry using isotope dilution with iodine-129. Clinical chemistry, 44(4), 817-824.
43. Santos-Figueroa, L. E., Moragues, M. E., Climent, E., Agostini, A., Martínez-Máñez, R., Sancenón, F. (2013). Chromogenic and fluorogenic chemosensors and reagents for anions. A comprehensive review of the years 2010–2011. Chemical Society Reviews, 42(8), 3489-3613.
44. Beer, P. D., & Gale, P. A. (2001). Anion recognition and sensing: the state of the art and future perspectives. Angewandte Chemie International Edition, 40(3), 486-516.
45. Davis, F., Collyer, S. D., Higson, S. P. (2005). The construction and operation of anion sensors: current status and future perspectives. In Anion Sensing (pp. 97-124).
Springer Berlin Heidelberg.
46. Gotor, R., Costero, A. M., Gil, S., Parra, M., Martínez-Máñez, R., Sancenón, F., Gaviña, P. (2013). Selective and sensitive chromogenic detection of cyanide and HCN in solution and in gas phase. Chemical Communications, 49(50), 5669-5671.
47. Guha, S., Saha, S. (2010). Fluoride ion sensing by an anion− π interaction. Journal of the American Chemical Society, 132(50), 17674-17677.
48. Kumar, V. (2013). Synthesis and characterization of multidentate Schiff base podands and their use as chemosensors and catalysts.
49. İnternet:URL:http://www.webcitation.org/query?url=http%3A%2F%2Fen.wikipedia .org%2Fwiki%2FOncogene&date=2015-12-07, Son Erişim Tarihi:07.12.2015
50. İnternet:URL:http://www.webcitation.org/query?url=http%3A%2F%2Fen.wikipedia .org%2Fwiki%2FCarcinoma&date=2015-12-07 Son Erişim Tarihi:07.12.2015
51. Barry B., Lowitz ve Dennis A. (2002). Casciato Medıcal Oncology &Prıncıples Of Cancer Bıology.
52. İnternet:URL:http://www.webcitation.org/query?url=http%3A%2F%2Fwww.pauleh rlich.de%2FLinks%2FE016827665.pdf&date=2015-12-07
53. Desoize, B., Madoulet, C. (2002). Particular aspects of platinum compounds used at present in cancer treatment. Critical reviews in oncology/hematology, 42(3), 317-325.
54. Huang, R., Wallqvist, A., Covell, D. G. (2005). Anticancer metal compounds in NCI's tumor-screening database: putative mode of action. Biochemical pharmacology, 69(7), 1009-1039.
55. Lebwohl, D., Canetta, R. (1998). Clinical development of platinum complexes in cancer therapy: an historical perspective and an update. European Journal of Cancer, 34(10), 1522-1534.
56. O'Dwyer, P. J., Stevenson, J. P., Johnson, S. W. (1999). Clinical Status of Cisplatin, Carboplatin, and Other Platinum‐Based Antitumor Drugs. Cisplatin: chemistry and biochemistry of a leading anticancer drug, 29-69.
57. İnternet:URL:http://www.webcitation.org/query?url=http%3A%2F%2Ftr.wikipedia.
60. Urus, S. (2004). The Bazı Metal-Fosfin Komplekslerinin Sentezi ve Antimikrobiyal Aktivitelerinin İncelenmesi. Yüksek Lisans Tezi, Fen Edebiyat Fakültesi Kimya Bölümü, Çukurova Üniversitesi. Adana.
61. Sneader, W. (1985). Drug discovery: the evolution of modern medicines. John Wiley
& Sons.
62. Rosenberg, B., Vancamp, L. (1969). Platinum compounds: a new class of potent antitumour agents. Nature, 222, 385-386.
63. Pil, P., Lippard, S. J., Bertino, J. R. (1997). Encyclopedia of cancer. Bertino JR, Academic Press, Department of Clinical Oncology, Hammersmith Hospital, DuCane Road, London, UK W12 0HS,(Serial Online), 392-410.Rosenberg, B. Spiro, T. G., (1980). In Nucleic Acid-Metal Ion Interactions. Ed. JohnWiley Sons, Inc.: pp. 1-29, New York.
64. Bertini, I., Gray, H. B., Lippard, S. J., Valentine, J. S. (1994). Bioinorganic chemistry.
University Science Books.
65. Kaim, W., Schwederski, B., Klein, A. (2013). Bioinorganic Chemistry--Inorganic Elements in the Chemistry of Life: An Introduction and Guide. John Wiley &
Sons.Kelland, L. R., Murrer, B. A., Abel, G., Giandomenico, C. M., Mistry, P., Harrap, K. R. (1992). Ammine/amine platinum (IV) dicarboxylates: a novel class of
platinum complex exhibiting selective cytotoxicity to intrinsically cisplatin-resistant human ovarian carcinoma cell lines. Cancer research, 52(4), 822-828.
66. Offiong, O. E., Martelli, S. (1997). Stereochemistry and antitumour activity of platinum metal complexes of 2-acetylpyridine thiosemicarbazones. Transition Metal Chemistry, 22(3), 263-269.
67. Pinedo, H. M., Schornagel, J. H. (1996). Platinum and other metal coordination compounds in cancer chemotherapy 2 (Vol. 2). Springer Science & Business Media.
68. Farrell, N. (1989). Transition Metal Complexes as Drugs and Chemotherapeutic AgentsKluwer Academic.
69. Conway, B., Shafran, S. D. (2000). Pharmacology and clinical experience with amprenavir. Expert opinion on investigational drugs, 9(2), 371-382.
70. Tušek-Boz̆ić, L., Matijašić, I., Bocelli, G., Sgarabotto, P., Furlani, A., Scarcia, V., Papaioannou, A. (1991). Preparation, characterization and activity of palladium (II) halide complexes with diethyl 8-quinolylmethylphosphonate (8-dqmp). X-ray crystal structure of [8-dqmpH] 2 [PdCl 4]· 2H 2 O and [8-dqmpH] 2 [Pd 2 Br 6]. Inorganica Chimica Acta, 185(2), 229-237.
71. Mansuri-Torshizi, H., Mital, R., Srivastava, T. S., Parekh, H., Chitnis, M. P. (1991).
Synthesis, characterization, and cytotoxic studies of α-diimine/1, 2-diamine platinum (II) and palladium (II) complexes of selenite and tellurite and binding of some of these complexes to DNA. Journal of inorganic biochemistry, 44(4), 239-247.
72. Butour, J. L., Wimmer, S., Wimmer, F., Castan, P. (1997). Palladium (II) compounds with potential antitumour properties and their platinum analogues: a comparative study of the reaction of some orotic acid derivatives with DNA in vitro. Chemico-biological interactions, 104(2), 165-178.
73. Wimmer, F. L., Wimmer, S., Castan, P., Cros, S., Johnson, N., Colacio-Rodrigez, E.
(1988). The antitumor activity of some palladium (II) complexes with chelating ligands. Anticancer research, 9(3), 791-793.
74. Zhao, G., Lin, H., Ping, Y., Sun, H., Zhu, S., Xuncheng, S., Chen, Y. (1999).
Ethylenediamine-palladium (II) complexes with pyridine and its derivatives:
synthesis, molecular structure and initial antitumor studies. Journal of inorganic biochemistry, 73(3), 145-149.
75. Caires, A. C. (2007). Recent advances involving palladium (II) complexes for the cancer therapy. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 7(5), 484-491.
76. Abu-Surrah, A. S., Al-Allaf, T. A., Rashan, L. J., Klinga, M., Leskelä, M. (2002).
Synthesis, crystal structure and initial biological evaluation of the new enantiomerically pure chiral palladium (II) complex trans-bis {endo-(1R)-1, 7,
7-trimethylbicyclo [2.2. 1]-heptan-2-amino} palladium (II) dichloride. European journal of medicinal chemistry, 37(11), 919-922.
77. Furlani, A., Scarcia, V., Faraglia, G., Sindellari, L., Zarli, B. (1982). In vitro cytostatic activity of palladium (II) and platinum (II) halide complexes with thiocarbamic esters.
Inorganica Chimica Acta, 67, L41-L45.
78. Carrara, M., Berti, T., D'Ancona, S., Cherchi, V., Sindellari, L. (1996). In vitro effect of Pt and Pd mercaptopyridine complexes. Anticancer research, 17(2A), 975-980.
79. Al-Allaf, T. A., Rashan, L. J. (1998). Synthesis and cytotoxic evaluation of the first trans-palladium (II) complex with naturally occurring alkaloid harmine. European journal of medicinal chemistry, 33(10), 817-820.
80. Abu-Surrah, A. S., Kettunen, M., Lappalainen, K., Piironen, U., Klinga, M., Leskelä, M. (2002). Synthesis of new chiral diimine palladium (II) and nickel (II) complexes bearing oxazoline-and myrtanyl-based nitrogen ligands. Crystal structure of the C 2-symmetric complex [{(1R, 2S)-inda-box} PdCl 2]. Polyhedron, 21(1), 27-31.
81. Trávníček, Z., Szűčová, L., Popa, I. (2007). Synthesis, characterization and assessment of the cytotoxic properties of cis and trans-[Pd (L) 2 Cl 2] complexes involving 6-benzylamino-9-isopropylpurine derivatives. Journal of inorganic biochemistry, 101(3), 477-492.
82. Huq, F., Tayyem, H., Beale, P., Yu, J. Q. (2007). Studies on the activity of three palladium (II) compounds of the form: trans-PdL 2 Cl 2 where L= 2-hydroxypyridine, 3-hydroxypyridine, and 4-hydroxypyridine. Journal of inorganic biochemistry, 101(1), 30-35.
83. Navarro-Ranniger, C., Lopez-Solera, I., Perez, J. M., Rodriguez, J., Garcia-Ruano, J.
L., Raithby, P. R., Alonso, C. (1993). Analysis of two cycloplatinated compounds derived from N-(4-methoxyphenyl)-. alpha.-benzoylbenzylidenamine. Comparison of the activity of these compounds with other isostructural cyclopalladated compounds.
Journal of medicinal chemistry, 36(24), 3795-3801.
84. Weber, U. S., Steffen, B., Siegers, C. P. (1998). Antitumor-activities of coumarin, 7-hydroxy-coumarin and its glucuronide in several human tumor cell lines. Research communications in molecular pathology and pharmacology, 99(2), 193-206.
85. Cooke, D. (1999). Studies on the mode of action of coumarins (coumarin, 6-hydroxycoumarin, 7-hydroxycoumarin & esculetin) at a cellular level (Doctoral dissertation, Dublin City University).
86. Egan, D., James, P., Cooke, D., O'Kennedy, R. (1997). Studies on the cytostatic and cytotoxic effects and mode of action of 8-nitro-7-hydroxycoumarin. Cancer letters, 118(2), 201-211.
87. Cooke, D., O'Kennedy, R. (1999). Comparison of the tetrazolium salt assay for succinate dehydrogenase with the cytosensor microphysiometer in the assessment of compound toxicities. Analytical biochemistry, 274(2), 188-194.
88. Budzisz, E., Brzezinska, E., Krajewska, U., Rozalski, M. (2003). Cytotoxic effects, alkylating properties and molecular modelling of coumarin derivatives and their phosphonic analogues. European journal of medicinal chemistry, 38(6), 597-603.
89. Grötz, K. A., Wüstenberg, P., Kohnen, R., Al-Nawas, B., Henneicke-von Zepelin, H.
H., Bockisch, A., Wagner, W. (2001). Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer–a prospective, randomized, placebo-controlled, double-blind study. British Journal of Oral and Maxillofacial Surgery, 39(1), 34-39.
90. İnternet:URL:http://www.webcitation.org/query?url=http%3A%2F%2Fkanser.gov.tr
93. Ihmels, H., Faulhaber, K., Vedaldi, D., Dall'Acqua, F., Viola, G. (2005). Intercalation of organic dye molecules into double-stranded DNA. Part 2: The annelated quinolizinium ion as a structural motif in DNA intercalators. Photochemistry and photobiology, 81(5), 1107-1115.
94. James, M. N. G., Watson, K. J. (1966). Chemistry of micrococcin P. Part IX. The crystal and molecular structure of micrococcinic acid bis-4-bromoanilide. Journal of the Chemical Society C: Organic, 1361-1371.
95. Kato, T., Ozaki, T., Tamura, K., Suzuki, Y., Akima, M., Ohi, N. (1998). Novel calcium antagonists with both calcium overload inhibition and antioxidant activity. 1.
2-(3, 5-di-tert-butyl-4-hydroxyphenyl)-3-(aminopropyl) thiazolidinones. Journal of medicinal chemistry, 41(22), 4309-4316.
96. Jayashree, B. S., Anuradha, D., Venugopala, K. N. (2005). Synthesis and Characterization of Schiff Bases of 2´-Amino-4-(6-chloro-3-coumarinyl) thiazole as Potential NSAIDs. Asian Journal of Chemistry, 17(4), 2093.
97. Naik, B., Desai, K. R. (2006). Novel approach for the rapid and efficient synthesis of heterocyclic Schiff bases and azetidinones under microwave irradiation. Indian Journal of Chemıstry Seciıon B, 45(1), 267.
98. Verma, P., Ahmad, S. (2011). Microwave Synthesis and Characterisation of Coumarin Based Ligands and their Metal Chelates. Oriental Journal of Chemistry, 27(1), 343.
99. Fathy Abdel-Wahab, B., Sediek, A., Ahmed Mohamed, H., Elsayed Ahmed Awad, G.
(2013). Novel 2-pyrazolin-1-ylthiazoles as potential antimicrobial agents. Letters in Drug Design & Discovery, 10(2), 111-118.
100. Arshad, A., Osman, H., Bagley, M. C., Lam, C. K., Mohamad, S., Zahariluddin, A.
S. M. (2011). Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives. European journal of medicinal chemistry, 46(9), 3788-3794.
101. Raza, R., Saeed, A., Arif, M., Mahmood, S., Muddassar, M., Raza, A., Iqbal, J.
(2012). Synthesis and Biological Evaluation of 3‐thiazolocoumarinyl Schiff‐base Derivatives as Cholinesterase Inhibitors. Chemical biology & drug design, 80(4), 605-615.
102. Alghool, S. (2010). Metal complexes of azo coumarin derivative: synthesis, spectroscopic, thermal, and antimicrobial studies. Journal of Coordination Chemistry, 63(18), 3322-3333.
103. Creaven, B. S., Egan, D. A., Kavanagh, K., McCann, M., Mahon, M., Noble, A., Walsh, M. (2005). Synthesis and antimicrobial activity of copper (II) and silver (I) complexes of hydroxynitrocoumarins: X-ray crystal structures of [Cu (hnc) 2 (H 2 O) 2]· 2H 2 O and [Ag (hnc)](hncH= 4-hydroxy-3-nitro-2H-chromen-2-one).
Polyhedron, 24(8), 949-957.
104. Creaven, B. S., Egan, D. A., Karcz, D., Kavanagh, K., McCann, M., Mahon, M., Walsh, M. (2007). Synthesis, characterisation and antimicrobial activity of copper (II) and manganese (II) complexes of coumarin-6, 7-dioxyacetic acid (cdoaH 2) and 4-methylcoumarin-6, 7-dioxyacetic acid (4-MecdoaH 2): X-ray crystal structures of [Cu (cdoa)(phen) 2]· 8.8 H 2 O and [Cu (4-Mecdoa)(phen) 2]· 13H 2 O (phen= 1, 10-phenanthroline). Journal of inorganic biochemistry, 101(8), 1108-1119.
105. Roy, S., Saha, R., Mondal, T. K., Sinha, C. (2014). Palladium (II) and platinum (II) complexes of N-{(2-pyridyl) methyliden}-6-coumarin and N-{(2-hydroxy) benzyliden}-6-coumarin. Inorganica Chimica Acta, 423, 52-61.
106. Jevtić, V. V., Pešić, M., Radić, G. P., Vuković, N., Sukdolak, S., Klisurić, O., Trifunović, S. R. (2013). Synthesis, characterization and cytotoxicity of a new palladium (II) complex with a coumarin-derived ligand. Crystal structure of 4-hydroxy-3-(1-(p-tolylimino) ethyl)-2H-chromen-2-one-palladium (II) complex.Journal of Molecular Structure, 1040, 216-220.
107. Arshad, A., Osman, H., Bagley, M. C., Lam, C. K., Mohamad, S., Zahariluddin, A.
S. M. (2011). Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives. European journal of medicinal chemistry, 46(9), 3788-3794.
108. Crosby, G. A., Demas, J. N. (1971). Measurement of photoluminescence quantum yields. Review. The Journal of Physical Chemistry, 75(8), 991-1024.
109. Aslan H.G. (2008). ‘‘Çeşitli sülfonamit türevleri ve bunların bazı geçiş metal komplekslerinin sentezi, antimikrobiyal etkilerinin incelenmesi’’, Doktora Tezi, Gazi Üniversitesi Fen Bilimleri Enstitüsü, Ankara, 27-29.
110. Anand, P., Singh, B., Singh, N. (2012). A review on coumarins as acetylcholinesterase inhibitors for Alzheimer’s disease. Bioorganic & medicinal chemistry, 20(3), 1175-1180.
111. Mouri, T., Yano, T., Kochi, S. I., Ando, T., & Hori, M. (2005). Synthesis and antifungal activity of new 3, 4, 7-trisubstituted coumarins. Journal of Pesticide Science, 30(3), 209-213.
ÖZGEÇMİŞ
Kişisel Bilgiler
Soyadı, adı : ŞAHİN, Ömer
Uyruğu : T.C.
Doğum tarihi ve yeri : 18/09/1987 Nevşehir
Medeni hali : Bekar
Telefon : 0 535 880 18 60
e-mail : omersahin1987@gmail.com
Eğitim Derecesi Okul/Program Mezuniyet yılı
Yüksek Lisans Gazi Üniversitesi/Kimya Bölümü Devam ediyor
Lisans İnönü Üniversitesi/ Kimya Bölümü 2011
Lise Konak Vali Nevzat Ayaz Lisesi 2004
İş Deneyimi, Yıl Çalıştığı Yer Görev
- - -
Kongreler
1. V. Ulusal Anogranik Kimya Kongresi 2015
2. 11th International Symposium on Pharmaceutical Sciences 2015 3. Trans Mediterranean Colloquium on Heterocyclic Chemistry 2015 Projeler
Tübitak 214Z152 nolu 3001 Projesi 2015
Erasmus Projesi ( RWTH Aachen Üniversitesi/ Almanya 2010-2011 )
Ödüller
V. Ulusal Anogranik Kimya Kongresi Mansiyon Ödülü
Yabancı Dili Almanca, İngilizce
Hobiler
Kitap okumak,Bilgisayar Teknolojileri, Ney üflemek, Fotoğrafçılık