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BIO 448 MOLECULAR BIOLOGY OF DIFFERENTIATION

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(1)

BIO 448

MOLECULAR BIOLOGY OF

DIFFERENTIATION

(2)

CELL DIFFERENTIATION

(3)

EMBRYOGENESIS

• Unfertilized egge

• 8-cell stage

• 16-cell stage

• 32-cell stage

• Morula

• Early blastula

(4)

EMBRYOGENESIS

• Unhatched blastula

• Hatched blastula

• Early mesenchyme blastula

(5)

EMBRYOGENESIS

• Late mesenchyme blastula

• Early gastrula

• Mid gastrula

• Late gastrula

(6)

• Control of early embryo development

*before genom activation

*after genome activation

(7)

• Carnegie Stages of Human Development fertilization

cleavage

blastulation gastrulation

Embryonic stem cells

(8)

Stem cell division

• Stem cells

• Progenitor cell

• Differentiated cell

(9)

Stem cell division

• Symmetric stem cell division

• Asymmetric stem cell division

• Progenitor division

• Terminal differentiation

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