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BIO 448 MOLECULAR BIOLOGY OF DIFFERENTIATION

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(1)

BIO 448

MOLECULAR BIOLOGY OF

DIFFERENTIATION

(2)

Nuclear totipotens

• a differentiated cell “dedifferentiates =

wrongly differentiates uncontrollably” and divides, as with most cancers formed as

tumor.

(3)

Genes are differentially expressed in cell differentiation

selector (selective) genes

(4)

The Role of Cytoplasmic Separation in Cell Identification

• Cytoplasmic Separation

• Induction

(5)

Eggs, Zygotes and Embryos Develop with Poles

• Polarity; one end different from another is evident in development.

• In some animals, the original polar distribution of materials in the egg's cytoplasm varies as a result of fertilization.

(6)

Cytoplasmic determinants

• To manage embryonic development of uneven distribution of materials in egg cytoplasm

• Exp: C. elegans

(7)

Induction

• The fate of some tissues is determined by

their interaction with other specific tissues in the embryo.

• Tissues manage the development of their neighbors by secreting inducers

• Ex: Signals in the vertebrate eye

(8)

Induction

• Even single cells can alert changes to their neighbors

• Ex. Anchor cell and vulva formation

Referanslar

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