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Molecular Biology of the Cell (© Garland Science 2008)

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Figure 12-45 Molecular Biology of the Cell (© Garland Science 2008)

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Yerleşim gerçekleştikten sonra Protein disülfit izomeraz tarafından serbest sülfidril gruplarının yükseltgenmesi sağlanır. Sitozol tarafı ise indirgeyici koşullar nedeniyle disülfit bağı oluşturmaz.

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Figure 12-50 Molecular Biology of the Cell (© Garland Science 2008)

Proteinlere şekerlerin kovalan olarak eklenmesi ER’da

gerçekleşir. Golgiye, plazma zarına ve diğer organellere

gönderilenler glikoproteinlerdir. Sitozolde kalanların ise

Serin yada treonin gruplarına N-asetilglukozamin takılır.

ER lümeninde yerleşik olan Oligosakkarit transferaz

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RFT1,

MPD, M5

Flippase

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54

Diabetes 2013 Feb; 62(2): 599-608.

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Endoplazmik Retikulum Stresi

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58

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Figure 12-57 Molecular Biology of the Cell (© Garland Science 2008)

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Figure 12-58 Molecular Biology of the Cell (© Garland Science 2008)

Serin aminoasitinden sfingozin amino alkolüne $

iki molekül yağ asiti eklenerek golgiye gönerilir. $

sfingomiyelin oluşturmak için yeni membran $

sentezinde kullanılır$

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