BIO 448
MOLECULAR BIOLOGY OF
DIFFERENTIATION
Cell Signaling for Cell
Differentiation
Cellular communication
• multistage process
• chemical signals
• membrane receptors
• relay the signal into the target cell's interior
• change the target cell's behavior.
Different types of cellular signaling affect various cell functions.
• Paracrine
• Autocrine
• Endocrine
• Synaptic
• Receptor Tyrosine Kinase Signaling
• Intracellular RTK Signaling Cascades
• WNT Signaling
• Canonical WNT Signaling
• Noncanonical WNT Signaling
• SHH Signaling
• Nerve cells signals
• Skin cells
• Muscle tissues
• Adrenal gland
• Blood vessels
THE ORCHESTRATION OF CELL DIFFERENTIATION AND
MORPHOGENESIS
• Fundamental Cellular Processes
• Proliferation by FGF Signaling
• Cell Fate Determination
• Cell Survival
• Cell Adhesion and Migration
• Cell Differentiation