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BIO 448 MOLECULAR BIOLOGY OF DIFFERENTIATION

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(1)

BIO 448

MOLECULAR BIOLOGY OF

DIFFERENTIATION

(2)

Cell Signaling for Cell

Differentiation

(3)

Cellular communication

• multistage process

• chemical signals

• membrane receptors

• relay the signal into the target cell's interior

• change the target cell's behavior.

(4)

Different types of cellular signaling affect various cell functions.

• Paracrine

• Autocrine

• Endocrine

• Synaptic

(5)

• Receptor Tyrosine Kinase Signaling

• Intracellular RTK Signaling Cascades

• WNT Signaling

• Canonical WNT Signaling

• Noncanonical WNT Signaling

• SHH Signaling

(6)

• Nerve cells signals

• Skin cells

• Muscle tissues

• Adrenal gland

• Blood vessels

(7)

THE ORCHESTRATION OF CELL DIFFERENTIATION AND

MORPHOGENESIS

(8)

• Fundamental Cellular Processes

• Proliferation by FGF Signaling

• Cell Fate Determination

• Cell Survival

• Cell Adhesion and Migration

• Cell Differentiation

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