Bala GÜR DEDEOĞLU
Doğum Tarihi : 14 Şubat 1978 Doğum Yeri : Denizli
Adres : Ankara Üniversitesi Biyoteknoloji Enstitüsü Merkez Laboratuvarları Tandoğan Yerleşkesi (Rektörlük Yanı) 06110 Beşevler /ANKARA
Telefon : +90532 704 0106 e-posta : gurbala@yahoo.com
EĞİTİM
Bilkent Universitesi, Doktora (2002-2009)
Moleküler Biyoloji ve Genetik Bölümü (Not ortalaması: 3.71/4.00) Orta Doğu Teknik Üniversitesi (ODTÜ), Yüksek Lisans (2000-2002) Biyoloji Bölümü (Not ortalaması: 3.10/4.00)
Orta Doğu Teknik Üniversitesi (ODTÜ), Lisans (1996-2000) Biyoloji Bölümü
BURSLAR
UNESCO - L'OREAL Ulusal Genç Bilim Kadınlarına Destek Bursu (2014)
Bilkent Universitesi Mühendislik ve Fen Fakültesi Doktora Eğitim Bursu (2002-2009) TÜBİTAK proje bursu (2007-2008)
The European Association for Cancer Research (EACR), U.K. EACR19, 2006, Kongre katılım bursu (2006)
ARAŞTIRMA PROJELERİ
Poli kistik over sendromlu (PKOS) hastaların ve normal kontrollerin granülosa hücrelerinde mikroRNA (miRNA) ifade profillerinin araştırılması (TUBITAK No: 112S579, Yürütücü)
Meme kanserinin histolojik ve patolojik alt tiplerinin meta-analiz yöntemine dayalı miRNA imzaları ile sınıflandırılması (TUBITAK No: 112T679, Yürütücü)
Tamoxifen ve Trastuzumab’a duyarlı meme kanseri hücrelerinde Tamoxifen ve Trastuzumab’a cevap veren miRNA profillerinin araştırılması (BAP No: 13B4143001, Yürütücü)
EGFR Odaklı Meme Kanseri Tedavilerinde miRNA Yanıtının Profillenmesi (BAP No: 14L0415001, Yürütücü)
Meme Kanserinde ER-HER2 ve ER-EGFR/IGFR Karşılıklı Etkileşiminin (Crosstalk) MikroRNA (MiRNA) Düzeyinde Araştırılması (TUBITAK No: 117Z634, Yürütücü)
ÖĞRETİM TECRÜBESİ
Ankara Üniversitesi Biyoteknoloji Enstitüsü (2012- )
“Yaşam Bilimlerinde Biyoinformatik”
“Kanserin Moleküler Biyolojisi”
“Araştırma Metodolojisi, Proje ve Bilimsel Yayın Hazırlama Teknikleri”
“Biyoteknoloji ve Genetik II”
Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü (2010-2012 )
Yarı zamanlı öğretim görevliliği, “BIN711 Applications of Bioinformatics in Molecular Biology”
Bilkent Universitesi Moleküler Biyoloji ve Genetik Bölümü (2002-2009) Lisans dersleri öğretim asistanlığı ve laboratuvar asistanlığı:
Molecular Biology of the Gene (2003-2007), Microbiology (2002), Molecular Biology of the Cell (2003), Techniques used in Molecular Genetics (2008).
Lisans üstü ders asistanlığı: Advanced Molecular Biology (2004-2007), Computational Biology (2006).
Stajer ve bitirme projelerinde asistanlık (2003-2009).
BECERİLER
Yabancı diller: İngilizce (KPDS:89; ÜDS:91.25), Almanca (Temel)
Bilgisayar bilgisi: MATLAB, MINITAB (İstatistik programı), MS uygulamaları
İŞ TECRÜBESİ
Ankara Üniversitesi Biyoteknoloji Enstitüsü (2011- ) Öğretim üyesi (Doç. Dr.)
Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü (2010-2012 )
Yarı zamanlı öğretim görevliliği, “BIN711 Applications of Bioinformatics in Molecular Biology”
Ankara Üniversitesi Biyoteknoloji Enstitüsü (2009-2011) Doktora sonrası araştırmacı (PostDoc)
AG Biyoinformatik (2008-2011) Kurucu ortak, yönetici
İntergen Genetik Araştırma ve Tanı Merkezi, ANKARA (2000-2001) Moleküler biyolog
YAYINLAR
Oztemur-Islakoglu Y., Noyan S., Gur Dedeoglu B.; hsa-miR-301a and SOX10 dependent miRNA-TF- mRNA regulatory circuits in breast cancer; Turkish Journal of Biology (Basım aşamasında)
Ozdogan H, Gur Dedeoglu B, Oztemur Islakoglu Y, Aydos A, Kose S, Atalay A, Yegin ZA, Avcu F, Uckan Cetinkaya D, Ilhan O. “DICER1 gene and miRNA dysregulation in mesenchymal stem cells of patients with myelodysplastic syndrome and acute myeloblastic leukemia” Leuk Res. 2017 Oct 31;63:62- 71. doi: 10.1016/j.leukres.2017.10.006.
Cilek EE, Ozturk H, Gur Dedeoglu B. “Construction of miRNA-miRNA networks revealing the complexity of miRNA-mediated mechanisms in trastuzumab treated breast cancer cell lines” PLoS One.
2017 Oct 5;12(10):e0185558. doi: 10.1371/journal.pone.0185558. eCollection 2017.
Aydos A, Gurel A, Oztemur Islakoglu Y, Noyan S, Gokce B, Ecemis T, Kaya C, Aksu AT, Gur Dedeoglu B “Identification of Polycystic Ovary Syndrome (PCOS) Specific Genes in Cumulus and Mural Granulosa Cells” PLoS One. 2016 Dec 20;11(12):e0168875. doi: 10.1371/journal.pone.0168875.
Coskunpinar E, Arkan H, Dedeoglu BG, Aksoz I, Polat E, Araz T, Aydos A, Oztemur Y, Akbas F, Onaran I. Determination of effective miRNAs in wound healing in an experimental Rat Model. Cell Mol Biol (Noisy-le-grand). 2015 Dec 24;61(8):89-96.
Oztemur Y, Bekmez T, Aydos A, Yulug IG, Bozkurt B, Dedeoglu BG. “A ranking-based meta-analysis reveals let-7 family as a meta-signature for grade classification in breast cancer. PLoS One. (2015) May 15;10(5):e0126837. doi: 10.1371/journal.pone.0126837. eCollection 2015.
Dedeoğlu BG. “High-Throughput Approaches for MicroRNA Expression Analysis.” Methods Mol Biol.
(2014) 1107:91-103. doi: 10.1007/978-1-62703-748-8_6.
Yashar Esmaeilian, Bala Gur Dedeoglu, Arzu Atalay, Esra Erdemli. “Investigation of stem cells in adult and prepubertal mouse ovaries” Advances in Bioscience and Biotechnology (2012) 3:936-944
Nelisa Lacin, Guldem Utkan, Tulin Kutsal, ErhanPiskin, Bala Gur Dedeoglu, Isık G. Yulug “TIMP-2 gene transfer by positively charged PEG-lated monosized polycationic carrier to smooth muscle cells” J Nanopart Res (2012) 14:694
Mumcuoglu M, Bagislar S, Yuzugullu H, Alotaibi H, Senturk S, Telkoparan P, Gur-Dedeoglu B, Cingoz B, Bozkurt B, Tazebay UH, Yulug IG, Akcali KC, Ozturk M. “The ability to generate senescent progeny as a mechanism underlying breast cancer cell heterogeneity.”PLoS One 2010 Jun 24;5(6):e11288
Bala Gur-Dedeoglu, Ozlen Konu, Betul Bozkurt, Gulusan Ergul, Selda Seckin, Isik G Yulug,
“Identification of suitable endogenous reference genes for gene expression analysis in breast tumor tissues”
Oncology Research 2009 17(8):353-65.
B. Gur-Dedeoglu, O. Konu, S. Kir, A. R. Ozturk, I. G. Yulug. “A Resampling Based Meta-Analysis for Detection of Differential Gene Expression in Breast Cancer” BMC Cancer. 2008 Dec 30;8:396.
Canbay E, Gur-Dedeoglu B, Bozkurt B. Karabeyoglu M, Unal B, Yildirim O, Cengiz O, Yulug IG
“Inhibition of focal adhesion kinase with her-2 targeted antibody pertuzumab (Omnitarg (R), 2C4) in breast cancer cells” 2008 Gene Therapy and Molecular Biology 12B: 293-299.
Baran Y, Gür B, Kaya P, Ural AU, Avcu F, Gündüz U, “Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance”,
Hematology 2007 Aug 15;:1 [Epub ahead of print].
Aslihan Petenkaya, Betul Bozkurt, Ozlem Akilli-Ozturk, Hatice Seda Kaya, Bala Gur-Dedeoglu and Isik G. Yulug, “Lack of Association between the MDM2-SNP309 Polymorphism and Breast Cancer Risk”, Anticancer Research 2006; 26: 4975-4978.
N. Ozturk, E. Erdal, M. Mumcuoglu, K. C. Akcali, O. Yalcin, S. Senturk, A. Arslan-Ergul, B.Gur, I.G.
Yulug, R. Cetin-Atalay, C. Yakicier, T. Yagci, M. Tez, M. Ozturk, “Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells”, Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2178-83.
HAKEMLİ DERGİLERDE YER ALAN YAYINLAR
Alp Aydos, Yasemin Öztemur, Bala Gür Dedeoğlu “Polikistik over sendromu ve moleküler yaklaşımlar- Polycystic ovary syndrome and molecular approaches” THDBD 2016; 73 – 1, Sayfalar 81 – 88. doi:
10.5505/TurkHijyen.2015.09327
Yasemin Öztemur, Alp Aydos, Bala Gür Dedeoğlu “Meme kanseri mikrodizin verilerinin biyoinformatik yöntemler ile bir araya getirilmesi - Meta-analiz yaklaşımları- Combination of breast cancer microarray data by using bioinformatic methods - Meta-analysis approaches” THDBD 2015; 72 – 2,
Sayfalar 155 – 162. doi: 10.5505/TurkHijyen.2015.54254
Yashar Esmaeilian, Bala Gur Dedeoglu, Arzu Atalay, Esra Erdemli. “Investigation of stem cells in adult and prepubertal mouse ovaries” Advances in Bioscience and Biotechnology (2012) 3:936-944
I. Yulug, B. Gur-Dedeoglu, “Functional Genomics in Translational Cancer Research: Focus on Breast Cancer”, Brief Funct Genomic Proteomic. 2008 Jan;7(1):1-7. Epub 2008 Mar 7. Review.
BİLİMSEL TOPLANTILARDA SUNULAN VE BİLDİRİ KİTABINDA BASILAN BİLDİRİLER
Y. Oztemur, A. Aydos, B. Gur Dedeoglu. “ TF-miRNA circuits specific to epithelial cancers” The FEBS Journal, Volume 283 Supplement 1 September 2016, P141.
Yucel Polat, Y. Oztemur, A. Aydos, B. Gur Dedeoglu. “Meta-analysis based miRNA signature discriminates cervical cancer from normal samples” The FEBS Journal, Volume 283 Supplement 1 September 1 2016, P143.
S. Noyan, H. Gurdal, B. Gur Dedeoglu. “The role of hsa-miR-X in cell motility and invasion in triple- negative breast cancer cell lines” European Journal of Cancer, Volume 68, Supplement 1, December 2016, P57. (28 EORTC – NCI – AACR Symposium on Molecular Targets and Cancer Therapeutics 2016
Munich, Germany).
Alp Aydos, Aykut Gurel, Yasemin Oztemur, Cemil Kaya, Tarik Aksu and Bala Gur-Dedeoglu” A
microRNA (miRNA) Signature in Granulosa Cells Specific to Polycystic Ovary Syndrome (PCOS)” Human Reproduction Volume 30, Supp1 2015, i436 ESHRE Annual Meeting 2015.
E. E. Cilek, B. Gur Dedeoglu . “miRNA mediated mechanisms of Trastuzumab and lapatinib treatment in breast cancer” The FEBS Journal,Volume 282 Supplement 1 July 2015, Berlin Germany
Y Oztemur, T Bekmez, A Aydos, I Yulug, BG Dedeoglu . “miRNA-mRNA integrated analysis in breast cancer: Let-7 cluster as a meta-signature for grade classification” European Journal of Cancer 50 (Supplement 5), S153-S154, 2014.
Esmaeilian, Yashar; Gür Dedeoğlu, Bala; Atalay, Arzu; Erdemli, Esra “Investigation of Stem Cells in Adult and Pre-adult Mouse Ovaries”, p:77, International Society for Stem Cell Research (ISSCR) 9th Annual Meeting, Toronto, Ontario Canada, June 15-18, 2011.
O. Akilli-Ozturk, B. Gur, O. Konu, I.G. Yulug. “Real-Time Quantitative RT-PCR Gene Expression Profile of Hedgehog Signaling Pathway in Epithelial Cancer Cell Lines” in the proceedings of the “19th Meeting of the European Association of Cancer Research”, p.105, Budapest, Hungary, 1-4 July 2006.
B. Gur, O. Konu, S. Kir, A. R. Ozturk, I. G. Yulug. “A Resampling Based Meta-Analysis for Detection of Differential Gene Expression in Breast Cancer” in the proceedings of the “19th Meeting of the European Association of Cancer Research”, p 158, Budapest, Hungary, 1-4 July 2006.
Bala Gür, Betül Bozkurt, Özlen Konu, Selda Seckin, Işık G .Yuluğ “Expression profiling of BRCA1- induced genes in primary breast tumors”, in the 31st FEBS Congress, Molecules in Health and Disease, 24- 29 June 2006, Istanbul-Turkey. FEBS JOURNAL 273: 224-224 PP544 Suppl. 1 JUN 2006
Ozlem Akıllı-Ozturk, Bala Gür, Betul Bozkurt, Selda Seckin, Isik G. Yulug “Gene Expression Analysis of Hedgehog Signaling Pathway Genes in Breast Cancer”, in the 31st FEBS Congress, Molecules in Health and Disease, 24-29 June 2006, Istanbul-Turkey. FEBS JOURNAL 273: 86-86 Suppl. 1 JUN 2006
Betül Bozkurt, Bala Gür, Emel Canbay, Ömer Cengiz, Işık G. Yuluğ “Focal adhesion kinase inhibition with her-2 pertuzumab antibody (2C4) in breast cancer cell lines.”National Surgery Congress 2006, 24-28 May 2006, Antalya-Turkey
Ö. Konu, B. Gür, A.R. Öztürk, I.G. Yuluğ “A re-sampling based meta-analysis approach for detection of differential expression in breast cancer subtypes”, in the Proceedings of HIBIT’05 International
Symposium on Health Informatics and Bioinformatics, Antalya, Turkey, 10-12 November 2005, p. 236.
I.G. Yulug, G. Çolakoglu, B. Bozkurt, B. Gür, Ö. Cengiz, D. Yannoukakos, I. Konstantopoulou, V.
Gerassimos, G. Nasioulas, T. Özçelik “p53 codon 72 and p21 codon 31 polymorphisms and susceptibility to breast cancer in the Turkish and Greek populations”, in the proceedings of the European Cancer Conference ECCO 13, Paris, France, 30 October – 3 November 2005. European Journal of Cancer, vol 3, No 2, October 2005, (ISSN 1359-6349).
B. Gur, B. Bozkurt, O. Konu, S. Seckin, I.G. Yulug“Real-time PCR-Based Expression Profiling of BRCA1-Induced Genes in Primary Breast Tumors” in the proceedings of the Third International
Symposium on the Molecular Biology of Breast Cancer, Molde, Norway, 22-26 June 2005. Breast Cancer Research, vol 7, Supplement 2, S41, P4.19, June 2005.
K. Ben Haj, B. Gur, B. Bozkurt, I.G. Yulug, C. Akcali, M. Ozturk “Expression profiling of Wnt pathway genes in breast cancer” in the proceedings of the Third International Symposium on the Molecular Biology of Breast Cancer, Molde, Norway, 22-26 June 2005. Breast Cancer Research, vol 7, Supplement 2, S41, P4.18, June 2005.
