ÖZGEÇMĐŞ
Dr. Emel Baloğlu
Đş Adresi:
Acıbadem Üniversitesi Tıp Fakültesi
Farmakoloji Anabilim Dalı, Kayışdağı Cad. No:32, 34752 Ataşehir-Đstanbul email: emel.baloglu@acibadem.edu.tr
Telefon: +90 216 500 4048
Eğitim:
Üniversite: Ankara Üniversitesi Tıp Fakültesi, Ankara, 2000
Uzmanlık: Ankara Üniversitesi Tıp Fakültesi, Farmakoloji ve Klinik Farmakoloji Ab.D, Ankara, 2002-2006
Doktora sonrası araştırmacı: Ruprecht-Karls-Heidelberg Üniversitesi, Tıp Fakültesi Medikal Klinik VII, Almanya Akciğer Hastalıkları Araştırma Merkezi (TLRC-H),Heidelberg, Almanya, 2006-2014
Akademik Ünvanlar:
Tıp Doktoru: 2000
Araştırma Görevlisi Dr., Ankara Üniversitesi Tıp Fakültesi, Farmakoloji ve Klinik Farmakoloji Anabilim Dalı, 2002-2006
Farmakoloji Uzmanı: 2006
Doktora Sonrası Araştırmacı: Ruprecht-Karls-Heidelberg Üniversitesi, Tıp Fakültesi Medikal Klinik VII, Almanya Akciğer Hastalıkları Araştırma Merkezi (TLRC-H),Heidelberg, Almanya, 2006-2014
Yardımcı Doçent:Acıbadem Üniversitesi Tıp Fakültesi, Farmakoloji Anabili Dalı, Ekim 2014-
Üyesi Olunan Kuruluşlar:
American Society for Pharmacology and Experimental Therapeutics (ASPET)
Ödüller:
1. TÜBĐTAK BĐDED 2232, Yurda Dönüş Araştırma Burs Programı, ‘Hipoksik
kardiyomiyositlerde HIF-2α geninin Na/K-ATPaz pompasının ekspresyon ve fonksiyonuna etkisinin incelenmesi’, 2015-
2. Araştırma ve Kongre Destek Ödülü: Heidelberg Üniversitesi Tıp Fakültesi“Graduiertenakademie”, 2009
3. Araştırma ve Kongre Destek Ödülü: Heidelberg Üniversitesi Tıp Fakültesi,
“Graduiertenakademie”, 2008
Uluslararası Hakemli Dergilerde Yayınlanan Makaleler:
1. Wujak ŁA, Blume A, Baloğlu E, Wygrecka M, Wygowski J, Herold S, Mayer K, Vadász I, Besuch P, Mairbäurl H, Seeger W, Morty RE. FXYD1 negatively regulates Na+/K+-ATPase activity in lung alveolar epithelial cells. Respir Physiol Neurobiol. 2015 Sep 26;220:54-61.
doi: 10.1016/j.resp.2015.09.008. [Epub ahead of print] PMID: 26410457
2. Mairbäurl H, Baloğlu E. Rebuttal to the PRO Statement.High Alt Med Biol. 2015 Sep;16(3):194. doi: 10.1089/ham.2015.0075. Epub 2015 Aug 25. PMID: 26305427 3. Mairbäurl H, Baloğlu E. Con: Corticosteroids Are Useful in the Management of HAPE.
High Alt Med Biol. 2015 Sep;16(3):190-2. doi: 10.1089/ham.2015.0071. Epub 2015 Aug 25.
PMID: 26305280
4. Baloğlu,E., ReingruberT., Bärtsch, P., Mairbäurl,H. β2-adrenergics in hypoxia desensitize receptors but blunt inhibition of reabsorption in rat lung. Am J Respir Cell Mol Biol. 2011 Nov;45(5):1059-68. doi: 10.1165/rcmb.2010-0273OC. Epub 2011 May 11.
5. Loeh, B., Baloğlu, E., Ke, A., Bartsch, P., Mairbaurl, H. β2-adrenergic stimulation blunts inhibition of epithelial ion transport by hypoxia of rat alveolar epithelial cells.
Cell Physiol Biochem. 2010;25(1):123-34. doi: 10.1159/000272057. Epub 2009 Dec 22.
6. Baloğlu, E., Ke, A., Abu-Taha, I.H., Bartsch, P., Mairbaurl, H. In vitro hypoxia inhibits β2 adrenergic receptor signaling in primary rat lung alveolar epithelial cells.
Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L500-9. doi:
10.1152/ajplung.90390.2008. Epub 2008 Dec 19.
7. Güney, S., Schuler, A., Ott, A., Hoschele, S., Baloğlu, E., Bartsch, P., Mairbaurl, H.
Dexamethasone prevents transport inhibition by hypoxia in rat lung and alveolar epithelial cells by stimulating activity and expression of Na/K-ATPase and ENaC.
Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1332-8. Epub 2007 Sep 14.
8. Baloğlu, E., Kiziltepe, O., Gurdal, H. The role of Gi proteins in reduced vasorelaxation response to β adrenergic receptor agonist in rat thoracic aorta during maturation. Eur J Pharmacol. 2007 Jun 14;564(1-3):167-73. Epub 2007 Mar 7.
Sunumlar
: Sözlü sunumlar1. H. Mairbaurl, E. Baloglu, Y. Zhang. Hypoxia prevents the mitochondrial oxygen consumption induced by stimulation of AMPK in cardiomyocytes “92th Annual Meeting of the German Physiological Society”, Mart 2-5, 2013, Heidelberg, Almanya.
2. E. Baloglu, H. Mairbaurl. Mechanisms of LPS induced impairment of alveolar Na-transport by stimulated macrophages and effects of hypoxia. “Turkish-FEBS Physiology Congress”, Workshop I, Lung, Macrophages, Hypoxia and Inflammation, Eylül 3-7, Đstanbul, Türkiye, 2011 3. E. Baloglu, H. Mairbaurl. Handling cells in hypoxia. “Turkish-FEBS Physiology Congress”, Workshop I, Lung, Macrophages, Hypoxia and Inflammation, Eylül 3-7, Đstanbul, Türkiye, 2011 4. E. Baloglu, H. Mairbaurl. Endotoxin and hypoxia increase the expression of pro-inflammatory cytokines from alveolar macrophages, ATII cells, and endothelial cells in-vitro. “Turkish-FEBS Physiology Congress”, Workshop I, Lung, Macrophages, Hypoxia and Inflammation, Eylül 3-7, Đstanbul, Türkiye, 2011
5. E. Baloglu, N. Yazihan, P. Bartsch, H. Mairbaurl. Effects of endotoxin and hypoxia on the expression of pro-inflammatory cytokines in lung macrophages, epithelial and endothelial cells and on ion transport in vitro. “Joint Meeting of German and Scandinavian Physiological Societies”, Kopenhag, Danimarka, Mart 27-30, 2010
6.E. Baloglu, B. Loeh, P. Bartsch, H. Mairbaurl.Hypoxia impairs beta 2 adrenergic signaling and stimulation of alveolar reabsorption in rat alveolar epithelial cells. European Respiratory Society Meeting, Viyana, Avusturya, Eylül 12-16, 2009
7. E. Baloglu, A. Ke, P. Bartsch, H. Mairbaurl. Pertussis toxin prevents hypoxia-induced impairment of β2-adrenergic signaling in primary rat alveolar epithelial cells. “87th Annual Meeting of the German Physiological Society”, Köln, Almanya, Mart 2-5, 2008.
Basılı bildiriler (Proceedings)
1. E. Baloglu, , K. Velineni, H. Mairbaurl. HIF-2α Dependent Regulation of Decreased Activity of ENaC in Hypoxic Alveolar Epithelial Cells. American Thoracic Society Meeting, Mayıs 15- 20, 2015, Denver, Kolorado, ABD, Am J Respir Crit Care Med.,A56. (PATHO)-
PHYSIOLOGY OF THE ALVEOLUS, 2015: A2033, 10.1164/ajrccm- conference.2015.191.1_MeetingAbstracts.A2033
2. E. Ermis Kaya, E. Baloglu, M. Meister, S. Cebesoy, H. Mairbaurl. Hypoxia-Dependent Signals From Lung Adenocarcinoma Cells Impair Na- Transport In Human Alveolar Epithelium.
American Thoracic Society Meeting, Mayıs 15-20, 2015, Denver, Kolorado, ABD, Am J Respir Crit Care Med., A56. (PATHO)-PHYSIOLOGY OF THE ALVEOLUS, 2015: A2035,
10.1164/ajrccm-conference.2015.191.1_MeetingAbstracts.A2035
3. K. Velineni, E. Baloglu, H. Mairbaurl, Inhibition of Alveolar Reabsorption by Stimulated Macrophages on Rat Alveolar Epithelial Cells. American Thoracic Society Meeting, Mayıs 15- 20, 2015, Denver, Kolorado, ABD, Am J Respir Crit Care Med.,A31. THE EPITHELIUM IN LUNG INFLAMMATION, 2015: A1289, 10.1164/ajrccm-
conference.2015.191.1_MeetingAbstracts.A1289
4. E. Baloğlu, K.Velineni, H. Mairbaeurl. HIF-2α is involved in the decreased activitiy of ENaC in hypoxic alveolar epithelial cells.“93th Annual Meeting of German Physiological Society”, Mart 13-15, 2014, Mainz, Almanya, Acta Physiologica, March 2014, Volume 210, Supplement 695, 217.
5. E. Baloğlu, K.Velineni, H. Mairbaeurl. Hypoxia decrease Na/K-ATPase transcription and activity by HIF dependent manner.“93th Annual Meeting of German Physiological Society”, Mart 13-15, 2014, Mainz, Almanya, Acta Physiologica, March 2014, Volume 210, Supplement 695, 217.
6. K.Velineni, E. Baloğlu, H. Mairbaeurl. Role of HIF in the inflammatory response at the alveolar epithelium and macrophages.“93th Annual Meeting of German Physiological Society”, Mart 13-15, 2014, Mainz, Almanya, Acta Physiologica, March 2014, Volume 210, Supplement 695, 155.
7. E. Baloğlu, L. Berg, K.Velineni, H. Mairbäurl. Increased HIF does not cause inhibition of alveolar epithelial ion transport in hypoxia. “92th Annual Meeting of German Physiological Society”, Mart 2-5, 2013, Heidelberg, Almanya, Acta Physiologica, March 2013, Volume 207, Supplement 694, 171-172.
8. K.Velineni, E. Baloğlu, H. Mairbäurl. HIF-1α enhances the enhanced inflamatory response at the alveolar epithelium induced by stimulated macrophages. “92th Annual Meeting of German Physiological Society”, Mart 2-5, 2013, Heidelberg, Almanya, Acta Physiologica, March 2013, Volume 207, Supplement 694, 172.
9. E. Baloğlu, T. Reingruber, P. Bartsch, H. Mairbaurl. In-vivo Hypoxia and terbutaline- treatment impairs beta-2-adrenergic signalling in ATII cells but blunts hypoxic inhibition of alveolar reabsorption. American Thoracic Society Meeting, Mayis 14-19, 2010, New Orleans, Louisiana, ABD Am J Respir Crit Care Med 181;2010:A6363
10. E. Baloğlu, N. Yazıhan, P. Bärtsch, H. Mairbäurl. Endotoxin but not hypoxia increases the expression of pro-inflammatory cytokines from alveolar macrophages, ATII and endothelial cells in an in-vitro model of the alveolar barrier. American Thoracic Society Meeting, Mayis 14-19, 2010, New Orleans, Louisiana, ABD. Am J Respir Crit Care Med 181;2010:A1294.
11. E. Baloğlu, T. Reingruber, P. Bartsch, H. Mairbaurl. Prolonged treatment with terbutaline blunts hypoxic inhibition of alveolar reabsorption in-vivo. “Joint Meeting of German and Scandinavian Physiological Societies”, Mart 27-30, 2010, Kopenhag, Danimarka Acta Physiologica (2010); 198:202-203 Suppl 677, March.
12. E. Baloğlu, A. Ke, P. Bartsch, H. Mairbaurl. Hypoxia impairs β2-adrenergic receptor signaling through pertussis toxin sensitive mechanisms in rat primary alveolar cells. “XXXVIII International Congress of Physiological Science and Experimental Biology Meeting”, Nisan 5-9, 2008, San Diego, Kaliforniya, ABD. FASEB J 2008;22:748.8-748
13. E. Baloğlu, A. Ke, P. Bartsch, H. Mairbaurl. Pertussis toxin prevents hypoxia-induced impairment of beta2-adrenergic signaling in primary rat alveolar epithelial cells “87th Annual Meeting of the German Physiological Society”, Mart 2-5, 2008, Köln, Almanya Acta
Physiologica (2008); 192:89-89 Suppl. 663, March.
14. E. Baloğlu ve H. Gürdal. Chronic treatment with beta-adrenergic receptor antagonists
aorta. Experimental Biology Meeting, Mart 31-Nisan 5, 2005, San Diego, Kaliforniya, ABD, FASEB J 2005; 19 (4): A107-A107 Part 1 Suppl. S MAR 4
15. F. Ademoğlu, N. Abacıoğlu, E. Baloğlu, H. Gürdal. The Effect of Ghrelin on Adenylyl Cyclase and PL-C Activity in Rat Aorta. “4th European Meeting on Vascular Biology and Medicine”, Eylül 28-30, Hamburg, Almanya, 2005. J of Vasc Res. 2005 Sept (42), suppl II/114- 115:328.
Basılmamış kongre bildirileri
1. E. Baloglu, L. Berg, K. Velineni, Mairbaeurl. Increased HIF does not cause inhibition of alveolar epithelial ion transport in hypoxia. Oxygen 2013, Dealing with hypoxia: Regulatory aspects in cells, tissues and organisms, Haziran 8-12, 2013, Oulu, Finlandiya.
2. E. Baloğlu, G. Nonnenmacher, P. Bartsch, H. Mairbaurl. HIF is required to maintain alveolar epithelial cell function in hypoxia. Keystone Symposia, Advances in Hypoxic Signaling: From Bench to Bedside, Şubat 12-17, 2012, Banff, Alberta, Kanada.
3. Y. Zhang, E. Baloğlu, P. Bartsch, H. Mairbaurl. Increase in cell metabolism by stimulation of AMPK and ERRa in cardiomyocytes is abolished by hypoxia. Keystone Symposia, Advances in Hypoxic Signaling: From Bench to Bedside, Şubat 12-17, 2012, Banff, Alberta, Kanada
4. E. Baloğlu, G. Nonnenmacher, H. Mairbaurl. Beta 2 adrenergic stimulation increases the expression of HIF-1α and HIF-2α. HypoxiaNet, “Sensing Hypoxia in the Cell and the Organism”, Eylül 20-23, 2012, Essen, Almanya.
5. E. Baloğlu, G. Nonnenmacher, H. Mairbaurl. Beta 2 adrenergic stimulation increases the expression of HIF-1α and HIF-2α. “91th Annual Meeting of German Physiological Society”, Mart 22-25, 2012, Dresden, Almanya
6. E. Baloglu, B. Loeh, A. Ke, I. Abu-Taha, P. Bartsch, H. Mairbaurl. Beta 2 adrenergic stimulation blunts hypoxic inhibition of alveola epithelial reabsroption despite impaired, Gi protein dependent inhibition of signaling in rat alveolar epithelial cells. “Pulomonet Congress 2009”, Mart 12-15 2009, Insbruck, Tyrol, Avusturya.
7. E. Baloğlu, A. Ke, P. Bartsch, H. Mairbaurl. Hypoxia impairs beta2 adrenergic receptor signaling in rat primary alveolar cells by pertussis toxin sensitive mechanisms. Pulmonet International Meeting “Secretion and Transport in Normal and Diseased Pulmonary Epithelia”, Mart 10-11, Saarbruecken, Almanya
Türkçe Makaleler:
1. Cengiz, AT., Kiyan, M., Tibet, M., Bingöl, M., Tural, T., Baloğlu, E., Çapka, DU. Saglikli Bireylerin Serumlarinda Cytomegalovirus (CMV) IgG Antikorlarinin ELISA yöntemiyle arastirilmasi. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 49 (1), 1996.
Türkçe Sunumlar:
1. E. Baloğlu, K.Velineni, H. Mairbaeurl. ‘Hipoksik alveol epitel hücrelerinde epitel hücre Na kanallarının aktivite ve ekspresyonunun düzenlenmesinde HIF-2α nın rolü’. 23. Ulusal Türk Farmakoloji Derneği Kongresi, 7-10 Eylül, 2015, Ankara, Türkiye.
1. E. Baloğlu ve Hakan Gürdal. Sıçan damar düz kasinda yas artışı ve maturasyon boyunca beta adrenerjik reseptör yanıtlarında pertussis toxin sensitif G proteinlerinin rölü. 18.Ulusal Türk Farmakoloji Derneği Kongresi, 28 Eylül-1 Ekim, 2005, Đzmir, Türkiye.
