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肝炎生藥之研究

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肝炎生藥之研究

中文摘要

本論文,就台灣民間治療肝炎單味材料,與臨床中醫師中藥處方二部分,探討 治療肝

炎生藥之肝障礙抑制作用。

?民間常用肝炎治療藥材 40 種,利用 Wistar 系大白鼠初代培養肝細胞受四氯化 碳引發

肝障礙抑制之體外試驗,作初步藥效評估。其中黃水茄等18 種藥材,證實具有 明顯之

肝障礙抑制效果。其中由虎杖之活性劃分部,單離出三種活性成分:

Torachrysone,

β-sitosterol ,Emodin。由黃水茄之活性劃分部單離出 β-sitosterol 及 β-sitos teryl glucoside 等。

?小柴胡湯為中國、日本、韓國臨床上用於治療急慢性肝炎之處方。本研究利用體

及體外之肝障礙病態動物實驗模式,評估本首中醫師臨床常用小柴胡湯加減方 之藥效

。結果以小柴胡湯加牡蠣減大棗及小柴胡湯如牡蠣效果最佳,同時採用TLC scanner

,對小柴胡湯及加減方中之Saikosaponina 、d 做定性、定量,證明小柴胡湯加牡

及小柴胡湯加牡蠣減大棗之Saikcsponins 主成分之變化,能影響其肝障礙之抑 制作用

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