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Myeloid maturation potentiates STAT3-mediated atypical IFN-gamma signaling and upregulation of PD-1 ligands in AML and MDS

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Academic year: 2021

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Figure 1. CD11b +  MDS and AML cells have increased capacity to express PD-1 ligands in response to IFN-γ
Figure 3.  Interfering the STAT1/STAT3 pathway with the small-molecule stattic hinders the IFN-γ-induced  upregulation of PD-1 ligands in myeloid leukemia cells
Figure 5.  Schematic demonstration of the major findings. (1) Maturation of AML or MDS cells was stimulated  by ATRA or D3 treatment and myeloid maturation could be followed by CD11b positivity

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