BIO 448
MOLECULAR BIOLOGY OF
DIFFERENTIATION
Cell differentiation mechanisms
Transcriptional regulation of gene expression
• Transcription factors and activation of specific promoters…
Transcriptional regulation of gene expression
• Developmental genetics is a discipline that
examines how the genotype transforms into the phenotype
Differential gene transcription regulates the transcription of nuclear genes into RNA.
• Selective nuclear RNA processing
Differential gene transcription regulates the transcription of nuclear genes into RNA.
• Selective mRNA translation
Differential gene transcription regulates the transcription of nuclear genes into RNA.
•Differential protein modification
Gene structure
• promotor
• CAP
• ATG codon
• leader sequence
• TATA box
• termination
• poly A tail
• enhancers
• transcription factors