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BIO 448 MOLECULAR BIOLOGY OF DIFFERENTIATION

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(1)

BIO 448

MOLECULAR BIOLOGY OF

DIFFERENTIATION

(2)

Cell differentiation mechanisms

(3)

Transcriptional regulation of gene expression

• Transcription factors and activation of specific promoters…

(4)

Transcriptional regulation of gene expression

• Developmental genetics is a discipline that

examines how the genotype transforms into the phenotype

(5)

Differential gene transcription regulates the transcription of nuclear genes into RNA.

• Selective nuclear RNA processing

(6)

Differential gene transcription regulates the transcription of nuclear genes into RNA.

• Selective mRNA translation

(7)

Differential gene transcription regulates the transcription of nuclear genes into RNA.

•Differential protein modification

(8)

Gene structure

(9)

• promotor

• CAP

• ATG codon

• leader sequence

• TATA box

(10)

• termination

• poly A tail

• enhancers

• transcription factors

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