Scifinder 使用練習及心得
首先
,我想查閱有關抗微生物藥品的資料
在搜尋框輸入
antibiotic 後，
我得到 297477 比內容有關antibiotic 的資料
選取第一筆的資料查閱如下
:
1. Polymorphism and crystal transformation of penicillin
sulfoxide
By: Jing, Dingding; Wang, Yongli; Chen, Zhijian; Zhou, Lina; Wang, Jingkang
Penicillin sulfoxide is the intermediate for the synthesis of
7-amino-3-desacetoxycephalosporanic acid which is one of the most important nucleuses of cephalosporin antibiotic. In this contribution, two crystal structures of penicillin sulfoxide (forms I and II) were detd. by X-ray diffraction, and their thermotropic properties were investigated by differential scanning calorimetry (DSC). Furthermore, the transformation of form II to form I was studied quant. by Raman spectroscopy, and its rates at different temps. were detd. The results indicate that penicillin sulfoxide is more stable as form I, and the temp. plays an important role in the crystal transformation.
快速看完後，我了解這篇主要是在講
penicillin
我覺得挺有用，但還想看看別得主題
Penicillin 我已經懂了，現在我想查查別的藥物
我選了第
3 筆資料
3. Biosynthesis of 16-membered macrolide antibiotic FD-891
By: Kudo, F.; Motegi, A.; Komatsubara, A.; Eguchi, T.
FD-891 is a 16-membered cytotoxic antibiotic macrolide, which is esp. active against human leukemia such as HL-60 and Jurkat cells. In the present study, we identified the FD-891 biosynthetic (gfs) gene cluster from the producer Streptomyces graminofaciens A-8890 using with typical modular type I polyketide synthase (PKS) genes as probe. The gfs gene cluster contained five typical modular type I PKS genes (gfsA, B, C, D and E), a cytochrome P 450 gene (gfsF), a methyltransferase gene (gfsG) and a regulator gene (gfsR). The gene organization of PKSs agreed well with the basic polyketide skeleton of FD-891 including the oxidn. states and a-alkyl substituent detd. by the substrate specificities of the acyltransferase (AT) domains. To clarify involvement of the gfs genes in the FD-891 biosynthesis, the P 450 gfsF gene was inactivated resulting in the loss of FD-891 prodn. Instead, the gfsF gene disrupted mutant accumulated a novel FD-891 analog 25-O-Me FD-892, which lacked the epoxide and the hydroxy group of FD-891. Furthermore, the recombinant GfsF enzyme co-expressed with putidaredoxin and putidaredoxin reductase converted 25-O-Me FD-892 to FD-891. In the course of the GfsF reaction, 10-deoxy FD-891 was isolated as an enzymic reaction intermediate, which was also converted to FD-891 by GfsF. Therefore, it was clearly found that a cytochrome P 450 GfsF catalyzes an epoxidn. and a hydroxylation with a stepwise manner in the FD-891 biosynthesis. These results clearly confirmed that the identified gfs genes are responsible to the biosynthesis of FD-891 in S. graminofaciens. Recent progress on the FD-891 biosynthetic study will be also discussed in this presentation.
