藥
3B b303098241 蔡丰正
SciFinder 學習心得與使用結果
在第一堂課程中
,發現到這門課程讓我又開心又驚喜, 因為 SciFinder
的好處實在太多了
.他結合了全世界所有的論文, 收集發表於期刊、專
利文件及其它相關文獻
, 資料包含了書目、摘要以及索引資訊,它從
1840 年成立到現在,每天都不斷更新, 總共收錄超過 3,000 萬筆的資
料
, 超過 10,000 種世界知名的科學期刊,翻譯超過 50 種各國語言與
185 個不同國家的科學文章,老師說他在世界上有超過 900 個博士在
這機構工作
,世界上有超過一萬個以上的機構都在使用它,而到現在我
才知道有這麼方便的網站可以使用
.
有了
SciFinder,讓我在找資料的時候可以快速又方便,節省許多時間,因
為這網站還會幫大家把重點整理好
,讓我可以很明瞭的知道是不是自
己要找的資料
,它還可以把資料儲存下來讓下次我們登入時,可以快速
瀏覽自己看過的文章
,還可以讓我們把很難畫的化學結構直接切割儲
存
,或是搜尋所要資到的化合物的反應物,對於需要常看 paper 的人來
說
,這網站真是一大福音.
以下是我用
SciFinder 尋找食物中咖哩成分 curcuma 的資料
Safety assessment of a solid lipid curcumin particle preparation:
Acute and subchronic toxicity studies
By: Dadhaniya, Paresh; Patel, Chintan; Muchhara, Jayesh; Bhadja, Nilesh; Mathuria, Neeta; Vachhani, Kapil; Soni, Madhu G.
Curcumin, a polyphenol, is obtained from turmeric, the ground rhizomes of Curcuma longa L. Extensive research over the past half century has revealed several health benefits of curcumin. The objective of the present study was to investigate potential adverse effects, if any, of a novel solid lipid curcumin particle (SLCP) prepn. in rats following acute and subchronic administration. The oral LD50 of the prepn. in rats as well as in mice was found to be greater than 2000 mg/kg body wt. (bw). In the subchronic toxicity study, Wistar rats (10/sex/group) were administered via oral gavage 0 (control), 180, 360, and 720 mg/kg bw/day of SLCP prepn. for 90 days. Administration of the curcumin prepn. did not result in any toxicol. significant treatment-related changes in clin. (including behavioral) observations, ophthalmic examns., body wts., body wt. gains, feed consumption, and organ wts. No adverse effects of the curcumin prepn. were noted on the hematol., serum chem. parameters, and
urinalysis. Terminal necropsy did not reveal any treatment-related gross or histopathol. findings. Based on the results of this study, the No Obsd.-Adverse-Effect Level (NOAEL) for this standardized novel curcumin prepn. was detd. as 720 mg/kg bw/day, the highest dose tested.
