• Sonuç bulunamadı

Taipei Medical University Institutional Repository:Item 987654321/627

N/A
N/A
Info
İndir
Protected

Academic year: 2021

Share "Taipei Medical University Institutional Repository:Item 987654321/627"

Copied!
1
0
0

Yükleniyor.... (view fulltext now)

Şimdi indir ( 1 sayfa )

Tam metin

(1)

題名:Advance Diagnosis and Therapy of Early Gastric Cancer. 內視鏡診斷與治療的新進展2008

作者:張君照

貢獻者:醫學系內科學科

上傳時間:2009-08-13T03:33:08Z

摘要:As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter

hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably,

hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development.

Referanslar

Şimdi indir ( PDF - 1 sayfa - 34.80 KB )

Benzer Belgeler

Spine Involvement in Rheumatoid Arthritis

Klinik olarak RA hastalar›ndaki servikal tutulum esas olarak atlanto-aksiyel subluksasyon (AAS) (%65), odontoidin süperiora migrasyonu (%20) ve subaksiyel subluksasyon (SAS) (%15)

Yeni Symposium Dergisi

Öznel bir psiflik hâlin, afla¤› yukar› efl- zamanl› olarak fakat uzakta oluflan, eflzamanl›l›k nite- li¤e sâhip, nesnel bir olay›n asl›na uygun yans›mas›

Yeni Symposium Dergisi

of Psychiatry Sedat ÖZKAN, MD, Prof.. of Psychiatry Mine ÖZMEN,

Case Report: Ramsay-Hunt Syndrome, Peripheral Facial Paralysis Treated with Electrostimulatio

Klini¤imizde, medikal tedavi ile fasial sinir paralizisinde iyilefl- me sa¤lanamam›fl, ENMG ile sa¤ fasial sinirde tam aksonal dejene- rasyon tespit edilmifl olan, Ramsay-Hunt

Effects of Biofeedback Assisted Isometric Exercise and Electrical Stimulation on Pain, Anxiety and Depression Scores in Knee Osteoarthritis

Grup I ve Grup II’de WOMAC a¤r› skoru, WOMAC GYA skoru, anksiyete ve depresyon skorlar›nda TS istatistiksel olarak çok anlaml› düzelme tespit edildi (p<0,001) (Tablo 3)..

Economic Analysis of Dairy Farms in Province of Izmir

İncelenen işletmelerde işletme başına ortalama hayvan sayısı 49 baş, sağılan hayvan sayısı 22 baş, inek başına günlük ortalama süt verimi 22 kg ve ortalama laktasyon

Optimization of Enrichment of D-Pinitol in Carob Extract Using Nanofiltration Application Using the Response Surface Methodology

Nanofiltrasyon denemelerinden elde edilen permeatların sakkaroz içerikleri üzerine basınç, sıcaklık ve permeat/retentat oranı faktörlerinin etkileri

Daily workflow and workload of radiation oncology specialists in Turkey

Ayrıca yoğun hasta akışı olarak yıllık 1000 hasta üzerinde tedavi eden merkezlerin çoğunda uzman başına düşen yıllık hasta sayısının EST-