The role of platelet cgmp and camp values in predicting response to oral phosphodiesterase treatment in men with erectile dysfunction

Eur Urol Suppl 2010;9(2):122

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305

CAN ANDROGEN STATUS, DURATION OF ED OR

PARTNERSHIP-STATUS PREDICT PDE5- INHIBITOR

SUCCESS IN THE FIRST-LINE TREATMENT OF MEN WITH

ED?

3RQKRO]HU$_{0DGHUVEDFKHU6}_{6FKPHOOHU1}_{(VWHUEDXHU%}

1_{Donauspital - SMZ Ost, Dept. of Urology, Vienna, Austria,} 2_{Donauspital, Dept.}

of Urology, Vienna, Austria, 3_{Barmherzige Brüder Salzburg, Dept. of Urology,}

Salzburg, Austria, 4_{Paracelsus University Salzburg, Dept. of Urology, Salzburg,}

Austria

Introduction & Objectives: 3'(LQKLELWRUVUHSUHVHQWDKLJKO\VXFFHVVIXOᚏUVW OLQHWUHDWPHQWLQPHQZLWKHUHFWLOHG\VIXQFWLRQ('+RZHYHUDERXWRIPHQ GRQRWUHSRUWDQDGHTXDWHUHVSRQVHWRRUDOPHGLFDWLRQ$LPRIRXUVWXG\ZDVWR UHYHDOSUHGLFWRUVIRU3'(LQKLELWRUᚏUVWOLQHWKHUDS\IDLOXUHSDUWLFXODUO\IRFXVHG RQDQGURJHQVWDWXV

Material & Methods: $OO PHQ EHWZHHQ \UV RI DJH SUHVHQWLQJ ZLWKRXW DQ\ SULRU ('WKHUDS\ DW WKH DQGURORJLFDO RXWSDWLHQWFOLQLF RI WKH 3DUDFHOVXV 0HGLFDO 8QLYHUVLW\6DO]EXUJGXHWR('ZHUHRᚎHUHGWRHQWHUWKLVSURVSHFWLYHHYDOXDWLRQ 3DWLHQWVFRPSOHWHGDEDVHOLQHTXHVWLRQQDLUHDQGDVWDQGDUGLVHGKRUPRQDOVWDWXV ('ZDVTXDQWLᚏHGDFFRUGLQJWRWKH,,(),QDGGLWLRQYDULRXVDVSHFWVRISDUWQHUVKLS VWDWXVZHUHDVNHGIRU$IWHUZHHNVRIRUDOVLOGHQDᚏOPJWLPHVZHHNO\ DUHYDOXDWLRQWRRNSODFH Results: ,QWRWDOPHQZLWKDPHDQDJHRI\UVHQWHUHGRXUDQDO\VLV 0HDQWRWDOWHVWRVWHURQHZDVQJPOPHDQIUHHWHVWRVWHURQHSJPO DQGPHDQ'+($6XPROO0HDQ,,()ZDVDWEDVHOLQHDQG DIWHUZHHNVRIWUHDWPHQW3DUWQHUVKLSVWDWXVGLGQRWSUHGLFWVLOGHQDᚏOUHVSRQVH  KDG DQ ('GXUDWLRQ !D DQG KDG D VPDOOHU PHDQ ,,()VFRUH LPSURYHPHQW FRPSDUHGWRPHQZLWK('GXUDWLRQRIOHVVWKDQRQH\HDUYHUVXVSRLQWV 7RWDO WHVWRVWHURQH DQG IUHH WHVWRVWHURQHOHYHOV GLG QRW FRUUHVSRQG WR WKH ,,() UHVSRQVH\HWPHQZLWK'+($6EHORZXPROOKDGDPHDQ,,()LQFUHDVHRI YHUVXVSRLQWVLQPHQZLWK'+($6!XPROO:KHQGHᚏQLQJWUHDWPHQWVXFFHVV DVDQ,,()LQFUHDVH!SRLQWVPHQZLWK'+($6DERYHDYHUDJHKDGYHUVXV VXFHVVUDWHDQGPHQZLWK('GXUDWLRQ\UVKDGYHUVXVVXFFHVV UDWHQV Conclusions: $FFRUGLQJWRWKLVSLORWVWXG\VHUXPWHVWRVWHURQHDQGSDUWQHUVKLS VWDWXV GR QRW SUHGLFW VLOGHQDᚏO UHVSRQVH 7KH SRWHQWLDO UROH RI '+($6 ZLWK WKLV UHVSHFWZDUUDQWVIXUWKHUVWXGLHV

306

SEXUAL SELF-CONFIDENCE FOLLOWING TADALAFIL

_{ONCE-A-DAY VERSUS SILDENAFIL CITRATE AS}

NEEDED IN THE TREATMENT OF MEN WITH ERECTILE

DYSFUNCTION

5XELR$XULROHV(_3RUVW+_6WXFNH\%_{0DUWLQ0RUDOHV$}_.LP('_

+DFNHWW*_{0RQWRUVL)}_/HQHUR(_{%ĭWWQHU++X\QK11}_3LQWRQ3 1_{Asociacion Mexicana para La Salud Sexual, AC (AMSSAC), Mexico City,}

Mexico, 2_{Private Practice of Urology/Andrology, Hamburg, Germany,} 3_Keogh

Institute for Medical Research, Nedlands, Western Australia, Australia, 4_Urología

Andrología Integradas Y Medicina Sexual, Malaga, Spain, 5_{University of}

Tennessee, Graduate School of Medicine, Knoxville, United States of America,

6_{Good Hope Hospital, Sutton, Coldfield, United Kingdom,} 7_{San Raffaele Hospital,}

Milan, Italy, 8_{Eli Lilly USA LLC, Indianapolis, United States of America,} 9_Lilly

Deutschland GmbH, Medical Department, Bad Homburg, Germany, 10_{Eli Lilly}

Australia Pty Ltd, Intercontinental Information Sciences (ICIS), Macquarie Park, Australia, 11_{Eli Lilly USA LLC, Lilly Corporate Center, Indianapolis, United States}

of America

Introduction & Objectives: 3KRVSKRGLHVWHUDVH3'(LQKLELWRUVVXFKDVWDGDODᚏO DQGVLOGHQDᚏODUHWKHᚏUVWOLQHWUHDWPHQWFKRLFHIRUPHQZLWKHUHFWLOHG\VIXQFWLRQ ('6DIHDQGHᚎHFWLYHXVHRIWDGDODᚏORQFHDGD\2D'KDVEHHQGHPRQVWUDWHG +RZHYHUWKLVLVWKHᚏUVWGLUHFWFRPSDULVRQRIWDGDODᚏO2D'YVVLOGHQDᚏOFLWUDWHDV QHHGHGSURUHQDWD>351@RQSV\FKRVRFLDORXWFRPHVLQPHQZLWK('

Material & Methods: 7KLV ZDV D JOREDO PXOWLFHQWHU UDQGRPLVHG RSHQODEHO DFWLYHFRPSDUDWRUFRQWUROOHGFOLQLFDOWULDOLQPHQZLWKFKURQLF('DQGDKLVWRU\RI VXFFHVVIXO 351 XVH RI DQ\ 3'( LQKLELWRU 3DWLHQWV ZHUH UDQGRPLVHG WR RQH RI VL[WUHDWPHQWVHTXHQFHVLQD[FURVVRYHUGHVLJQWDGDODᚏO2D'WDGDODᚏO351 DQGVLOGHQDᚏOFLWUDWH351Q WKHPHDQDJHZDV\HDUVWKHPDMRULW\ZHUH &DXFDVLDQ >@ RU +LVSDQLF >@  KDG VHYHUH ('  UHSRUWHG SULRU WDGDODᚏO 351 XVH DQG  UHSRUWHG SULRU VLOGHQDᚏO FLWUDWH XVH(DFK VHTXHQFHLQYROYHGDQZHHNWUHDWPHQWSKDVHVHSDUDWHGE\DWRGD\ZDVK

303

THE ROLE OF PLATELET CGMP AND CAMP VALUES

_{IN PREDICTING RESPONSE TO ORAL}

PHOSPHODIE-STERASE TREATMENT IN MEN WITH ERECTILE

DYSFUNCTION

$NDQG0_{*¾OSóQDU2}_(UV¸]*_*HQFHU(_<DPDQ2_{˜]GLOHU(} 1_{Etimesgut Military Hospital, Dept. of Urology, Ankara, Turkey,} 2_{Ufuk University,}

School of Medicine, Dept. of Urology, Ankara, Turkey, 3_{University of Ankara,}

School of Medicine, Dept. of Physiology, Ankara, Turkey, 4_{University of Ankara,}

School of Medicine, Dept. of Urology, Ankara, Turkey

Introduction & Objectives: :HWULHGWRGHYHORSDODERUDWRU\WHVWE\XVLQJSODWHOHW F\FOLFJXDQRVLQHPRQRSKRVSKDWHF*03DQGF\FOLFDGHQRVLQHPRQRSKRVSKDWH F$03OHYHOVWRSUHGLFWWKHFOLQLFDOUHVSRQVHRISDWLHQWVZLWKHUHFWLOHG\VIXQFWLRQ ('WUHDWHGZLWKSKRVSKRGLHVWHUDVH3'(LQKLELWRUV

Material & Methods: %HWZHHQ2FWREHU)HEUXDU\SDWLHQWVUHIHUULQJ WR RXU FOLQLF EHFDXVH RI (' ZLWK DQ DYHUDJH DJH RI  \HDUV \ DQG  PHQZLWKDFRPSODLQWH[FHSW('ZLWKDQDYHUDJHDJHRI\HDUV\ZHUH HYDOXDWHGZLWKDGHWDLOHGKLVWRU\SK\VLFDOH[DPLQDWLRQODERUDWRU\WHVWVDQG,,() F*03  F$03 OHYHOV ZHUH DVVHVVHG DIWHU DGGLQJ VRGLXP QLWURSUXVVLGH 613 VLOGHQDᚏO6DQGYDUGHQDᚏO9WREORRGVDPSOHV

Results: 1R VWDWLVWLFDOO\ VLJQLᚏFDQW GLᚎHUHQFH ZDV GHWHUPLQHG IRU F*03613 F*036F*039EHWZHHQWKHSDWLHQWDQGFRQWUROJURXSV,QWKHFRQWUROJURXS ZKLOHF$036 F$039DUHVWDWLVWLFDOO\ORZHUWKDQF$03613SWKHUHLV QRGLᚎHUHQFHEHWZHHQF$036 F$039S!,QWKHSDWLHQWJURXSF$036 LVVWDWLVWLFDOO\VLJQLᚏFDQWO\ORZHUWKDQERWKF$03613 F$039S:KLOH QR VWDWLVWLFDOO\ VLJQLᚏFDQW GLᚎHUHQFH LV GHWHUPLQHG IRU WKH DOWHUDWLRQ EHWZHHQ F*03613 F*036F*03613 F*039F*036 F*039DQGF$03 613 F$036EHWZHHQWKHSDWLHQWDQGFRQWUROJURXSVDVWDWLVWLFDOO\VLJQLᚏFDQW GLᚎHUHQFH LV GHWHUPLQHG IRU WKH DOWHUDWLRQ EHWZHHQ F$03613  F$039 DQG F$036 F$039SIRUERWK

Conclusions: 'HWHUPLQLQJ WKDW WKHUH LV QR VWDWLVWLFDOO\ VLJQLᚏFDQW GLᚎHUHQFH IRU WKHDOWHUDWLRQEHWZHHQF*03613 F*036F*03613 F*039F*036 F*039DQGF$03613 F$036VKRZVWKDWSODWHOHWF*03OHYHOVFDQQRWEH XVHGDVDODERUDWRU\WHVWIRUSUHGLFWLQJWKHFOLQLFDOUHVSRQVHWR3'(LQKLELWRUV7KH VWDWLVWLFDOO\ VLJQLᚏFDQW GLᚎHUHQFH EHWZHHQ WKH SDWLHQW DQG FRQWURO JURXSV IRU WKH DOWHUDWLRQEHWZHHQF$03613 F$039DQGF$036 F$039PD\VKRZWKDW F$03LQFUHDVHFDQEHLQKLELWHGE\QRWIXOO\GHWHUPLQHGPHFKDQLVPVLQSDWLHQWV ZLWK('%\XQGHUVWDQGLQJWKHLQWHUDFWLRQVEHWZHHQF*03DQGF$03LQSODWHOHWV DQGFDYHUQRVDOWLVVXHDQGWKHWLVVXHGLVWULEXWLRQVDQGIXQFWLRQVRI3'(HQ]\PHV SURSHUO\LWFDQEHDEOHWRSUHGLFWWKHFOLQLFDOUHVSRQVHWR3'(LQKLELWRUV

304

DO PATIENTS’ BASELINE CHARACTERISTICS

_{PREDICT PDE5 INHIBITORS’ EFFICACY AND PATIENTS’}

PREFERENCE? A COMPARATIVE, RANDOMIZED,

OPEN-LABEL, CROSSOVER STUDY

7RXW]LDULV&_{6DOSLJLGLV*}_{+DW]LPRXUDWLGLV.}_{+DW]LFKULVWRX'} 1_{Aristotle University, 1st Dept. of Urology, Thessaloniki, Greece,} 2_Hippokratio

Hospital, Dept. of Urology, Thessaloniki, Greece, 3_{Aristotle University, 2nd Dept.}

of Urology, Thessaloniki, Greece

Introduction & Objectives: 7RLQYHVWLJDWHWKHHᚑFDF\WKHWROHUDELOLW\DQGWKHVLGH HᚎHFWVRIWKHWKUHHNQRZQRUDO3'(LQKLELWRUV6LOGQDᚏOYDUGHQDᚏO+&/WDGDODᚏO DQGLIWKHVHSDUDPHWHUVDUHLQᚐXHQFHGE\VSHFLᚏFSDWLHQWVಬFKDUDFWHULVWLFV

Material & Methods:  SDWLHQWV ZLWK (' ZHUH SDUWLFLSDWHG LQ WKH VWXG\ $OO RI WKHP FRPSOHWHG WKH ,,() TXHVWLRQQDLUH IROORZLQJ E\ D GHWDLOHG PHGLFDO DQG SV\FKRORJLFDO KLVWRU\ %DVHOLQH YDULDEOHV H[DPLQHG ZHUH DJH ERG\ PDVV LQGH[ DOFRKRO FRQVXPSWLRQ VPRNLQJ VWDWXV SK\VLFDO DFWLYLW\ (' DHWLRORJ\GXUDWLRQ FRPRUELGLWLHV LQ PHGLFDO KLVWRU\ PHGLFDWLRQ LQWDNH SV\FKRORJLFDO VWDWXV DQG EDVHOLQH VFRUHV IRU WKH ,,() GRPDLQV $IWHU D  ZHHNV VFUHHQLQJ SHULRG WKH\ UHFHLYHGDOOWKUHH3'(LQKLELWRUVZLWKLQFLGHQWDOVHTXHQFHᚏJ,QHYHU\IROORZ XS YLVLW WKH 6H[XDO HQFRXQWHU 3URᚏOH 6(3 GLDU\ ZHUH VHOHFWHG DQG WKH ,,() TXHVWLRQQDLUHZDVFRPSOHWHG*HQHUDOOLQHDUPRGHOUHSHDWHGPHDVXUHV$129$ FRQWUROOHGZHUHXVHGWRGHWHUPLQHLIDQ\EDVHOLQHFKDUDFWHULVWLFVZHUHDVVRFLDWHG ZLWK WKH HᚑFDF\ WROHUDELOLW\ DQG SDWLHQWVಬ SUHIHUHQFH 3RVWEDVHOLQH YDULDEOHV H[DPLQHGZHUHGLᚎHUHQFHVLQ,,()GRPDLQV6(3VFRUHVDQGWKHSUHVHQFHRIVLGH HᚎHFWV Results: SDWLHQWVFRPSOHWHGWKHWKUHHWUHDWPHQWVSHULRGDQGLQFOXGHGLQWKH DQDO\VLV3DUWLFLSDQWVಬ,,()VFRUHVZHUHVLJQLᚏFDQWO\ORZHUDWWKHEDVHOLQHFRPSDUHG WRWKHRWKHUYLVLWVLUUHVSHFWLYHRIWKHGUXJWDNHQ2QO\IRUWKH('VXEVFDOHWKHUH ZDVDVLJQLᚏFDQWGLᚎHUHQFHSEHWZHHQVLOGHQDᚏOXVHDQGWDGDODᚏOXVHDV WKH VWXG\ VDPSOH KDG VOLJKWO\ ORZHU ,,() VFRUH XVLQJ VLOGHODᚏO FRPSDUHG WR WKH