藥學科技二 報告 藥三 A B303098021 林宜萱
一、
檢索過程
圖書館首頁>電子資源>系統查詢>登錄系統(要先申請)>資料庫查詢>key in “scifinder”>登錄
>Explore references
二、
檢索結果
Scifinder
◎主題
:Difenidol
Diphenidol inhibited sodium currents and produced spinal anesthesia
By: Leung, Yuk-Man; Wu, Bor-Tsang; Chen, Yu-Chung; Hung, Ching-Hsia; Chen, Yu-Wen
The aim of this study was to evaluate the effect of diphenidol on blocking Na+ currents and spinal anesthesia. We used the patch-clamp method to examine if diphenidol blocked Na+ currents. Lidocaine, a common used local anesthesia, was used as control. We also evaluated the potencies and durations of diphenidol and lidocaine on spinal blockades of motor function, proprioception, and nociception in rats. Lidocaine exhibited a concn.- and
state-dependent effect on tonic blockade of voltage-gated Na+ currents in mouse
neuroblastoma N2A cells (IC50 of 8.1 and 138.9 μM at holding potentials of -70 and -100 mV, resp.). Diphenidol was more potent (IC50 of 0.77 and 62.6 μM at holding potentials of -70 and -100 mV, resp.). However, unlike lidocaine, block of Na+ currents by diphenidol lacked use-dependence. We also found that diphenidol acted like lidocaine and produced
dose-related spinal blockades of motor function, proprioception and nociception. Although diphenidol had similar potencies of spinal anesthesia compared with lidocaine it produced a much longer duration of spinal blockades than lidocaine. Our results demonstrated that intrathecal diphenidol produced a long duration and similar potency on spinal
anesthesia compared with lidocaine in rats. The anesthetic effect of diphenidol could be
in part due to its blockade of Na+ currents.
這個報告主要是以 lidocaine 為 control 組,去比較 diphenidol 阻礙鈉離子電流、 抑制行為動作的 potency 和 duration結論為 diphenidol 有較好的 duration 但 potency 與 lidocaine 差不多
以下為關於 diphenidol 的相關資訊,都是藉由 scifinder 所找到的資料
分子式: C21 H27 N O
別名: 1-Piperidinebutanol, α,α-diphenyl-,1,1-Diphenyl-4-piperidino-1-butanol; Avomol; Benzhydrol, α-(3-piperidinopropyl)-; Cephadol; Difenidol; Diphenadol; Diphenidol; Diphenyl[3-(1-piperidyl)propyl]carbinol; Lansenol; Nometic; SKF 478;
α,α-Diphenyl-1-piperidinebutanol 結構式 合成反應方程式 (關於這個有找到許多不同的合成方式,只選擇一種放上來)
Innovation
我在檢索的時候打了”phone”,結果跑出了一些東西,但我其實也按看不太懂那 是什麼。三、
心得
Scifinder
關於 scifinder,我選擇的主題是 diphenidol,當初上課在試用的時候,很快地就 選定了這個主題,原因是因為我本身是個非常容易暈車的人,而且暈車藥對我來 說完全沒有用,暑假去蘭嶼玩需要坐 3 個半小時的船,於是就到之前打工的藥局 詢問藥師,藥師就推薦我吃了這顆藥,原本在臨床上是用來治療暈眩噁心嘔吐。 結果我使用後的效果很好,雖然海上風浪很大,船上也有很多人吐,但我完全沒 有感到不舒服,從那次之後我就對這個藥印象深刻了。使用 scifinder 找 diphenidol 查到的資料非常多,除了關於 diphenidol 的結構、性 質、合成反應外,還有許多相關研究,包括他的衍生物特性(標題:
Diphenidol-related diamines as novel muscarinic M4 receptor
antagonists)等等,所以我個人覺得 scifinder 是個非常好用的檢索系統,尤其 對於像我們這種醫學相關科系的人,他提供我們一個實用的系統可以去搜尋專業 的資料,比起直接在搜尋引擎或維基百科等等搜尋所得的資料來的更正確,不過 他似乎只能用學校圖書館的電腦才能使用,而且同時間只能有 2 個使用者登錄, 這部分對於學生來說好像有點不太方便,希望能夠開放更多的人同時上線使用這 套檢索系統!!