VI ABSTARCT
SYNTHESIS AND APPLICATION OF NEW LYSINE BASED BIOCOMPATIBLE MATERIALS
PhD THESIS
Mehmet ÇOLAK
UNIVERSITY OF DICLE
INSTITUTE OF NATURAL AND APPLIED SCIENCES DEPARTMEN OF CHEMISTRY
2014
The driving forces for selfassembly of gelators are mainly intermolecular interactions, such as hydrogen bonding, π–π stacking, van der Waals interactions, coordination forces, charge transfer interactions, etc. These non-covalent interactions give rise to the formation of supramolecular structures of gelators and subsequently results in the immobilization of the fluid. Interestingly, research efforts have been focused on two-component gelators formed through hydrogen bonding, donor–acceptor interaction, metal ion coordination and acid–base interactions, which offer the potential of developing soft materials with highly tunable microscopic and macroscopic properties.
Although the two compounds forming two-component gelators do not have organogelation properties by themselves, they can function as an organogelator by the formation of a two component compound.
The gelation behavior of organic salt type organogelators, consisting of N€ -lauroyl-L-lysine ester and aliphatic acids have been illustrated by Hanabusa groups.
In this study, novel Nє-alcanoyl-L-lysine esters derivatives (Nє- myristoyl, Nє- palmitoyl) in addition to N€-Lauroyl-L-lysine ester were synthesized and used as a base component; Naproxen and Ibuprophen were used as a acid component, thus, 6 new two-component, topical, biocompatible potential organojelators were prepared.of which anion is NSAID drug active materials.
Key Words: L-Lysine Based Organogelators, Biocompatibility, Low Molecular Weight Organogel, Gel, Organic Synthesis, NSAID.
