Prof.Dr. Meral Tunçbilek
ISOMERISM IN DRUG
Method of resolution of racemic modification
Resolutıon of racemic acids
The most unremarkably used procedure for separating enantiomers is to convert them to a mix of diastereomers which will have totally different physical properties, freezing point, boiling purpose, solubility, and so on
If you have got a racemic or d,l mixture of enantiomers of associate acid and convert this to a salt with a chiral base
having the D configuration, the salt is a mixture of two diastereomers, D acid + D base and L acid + D base
• After separation of the diastereomers, the enantiomerically pure acids are recovered
• Racemic acids can be resolved using commercially available chiral bases such as 1-phenylethanamine
Resolutıon of racemic bases
Chiral acids; (+)-tartaric acid (-)-malic acid
(-)-mandelic acid and
(+)-camphor-10-sulfonic acid
Biochemical separation
In this methodology, bound small organism such as mold, bacterium, or fungi once allowed grow in an exceedingly answer of racemic mixture destroy one among the optical isomers at a way faster rate than the opposite thanks to selective assimilation.
Once Penicillium glaucum is allowed to grow in an exceedingly answer of ammonia salt, it destroys the dextro chemical compound effort the leavo chemical compound.
