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Mechanism of Ac.on and Effects of Drugs

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Mechanism of Ac.on and Effects of Drugs

Refer lecturer for course updated notes.

Students are oblidged to follow the courses for evalua.on process and presented notes are preliminary dra@s for the whole evalua.on

process.

Pharmacology 1 and

Prescription Knowledge

(2)

Non-structural property remedies

Physico-cehimcal property related effects Structural fearure

Custom domain-domain shape (receptor, transport protein, ion migra.on, G-protein, chemical messanger)

(3)

Isomerism

•  Structural Isomerism (Cons.tu.onal)

•  Chain isomerism

•  Posi.onal isomerism

•  Func.onal group isomerism

•  Stereoisomerism

•  Configura.onal

•  Geometric

•  Op.cal

•  Enan.omer

•  Diastereomers

•  Conforma.onal

(4)

•  Target points

•  Enzymes, an.metabolytes

•  Ion channels

•  Receptors

•  Transport systems

(5)

Receptors

•  Defini.on

•  Effects

•  Types

•  Drug-receptor interac.ons

•  Changing the number of receptors

•  Drug-receptor bonds

•  Drug receptor interac.on theories/hypotheses

(6)

•  Agonist

•  Antagonist

•  Par.al agonist-antagonist

(7)

•  Mechanisms fo drugs

•  Physical and chemical effects

(8)

•  Nuclear receptors

•  Substance P

•  VIP

(9)

•  Receptors and postreceptor events

•  G protein signaling

•  Secondary messangers

(10)

Drug interac.ons

•  Mechanisms of drug interac.ons

•  Pharmaceu.cal interac.ons

•  Pharmakokine.c interac.ons

•  Absorp.on/Distribu.on/Metabolism/Excre.on interac.ons

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