Evaluation of endothelial functions in patients with Behcet’s disease without overt vascular involvement

Evaluation of endothelial functions in patients with Behcet’s disease without overt vascular involvement

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Department of Cardiology, Florence Nightingale Hospital, Istanbul;

#Department of Dermatology, Istanbul Education and Research Hospital, Istanbul

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Mehmet Salih Gürel, M.D.,^# Saide Aytekin, M.D.

Objectives:%HKFHW·VGLVHDVH%'LVDFKURQLFLQÁDPPD- tory disease characterized by recurrent oral and genital ulcerations and ocular lesions. This multisystemic disorder primarily affects the vascular system. In the present study, we aimed to evaluate vascular endothelial function in pa- tients with Behcet’ s disease without vascular involvement.

Study design: We studied 40 patients with BD (44.9±5.4 years) and 20 healthy controls (45.4±8.2 years). Brachial artery Doppler ultrasonography (USG) and bilateral carotid artery intima-media thickness measurements were per- formed.

Results: Basal diameter of the brachial artery were similar EHWZHHQWKHWZRJURXSV+RZHYHUÁRZPHGLDWHGGLODWLRQZDV

markedly impaired in patients with Behcet’ s disease (p=0.03).

Nitrate-induced dilation values were similar between the two groups (p=0.16). Carotid artery intima-media thickness was slightly increased in the patient group compared to the control JURXSEXWWKHGLIIHUHQFHGLGQRWUHDFKVWDWLVWLFDOVLJQLÀFDQFH

(0.69±0.15 to 0.59±0.09 respectively; p=0.06).

Conclusion: Vascular endothelial function is impaired in BD. Brachial artery Doppler USG is a reliable and reproduc- ible method to establish changes in vascular functions.

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ABSTRACT ÖZET

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B

BD Behcet’ disease CCA Common carotid arteries CAD Coronary artery disease CIMT Carotid artery intima media thickness

FMD Flow-mediated dilatation USG Ultrasound

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PATIENTS AND METHODS

Study design and patient population

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RESULTS

Clinical characteristics and demographic data

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Table 1. Clinical and demographic characteristics

Variable Behcet’s disease Control group S

group (n=40) (n=20)

n % Mean±SD n % Mean±SD

Age (year) 44.9±5.4 45.4±8.2 0.345

Male gender (%) 59 60 0.618

Heart rate (per min) 73.1±1.6 73.7±1.3 0.84

BSA (m²) 1.75±0.18 1.81±0.16 0.241

SBP (mmHg) 130±12.3 129±13.6 0.77

DBP (mmHg) 69±12 70.1±12.4 0.89

Fasting glucose (mg/dl) 95±10 96±11 0.90

Total cholesterol (mg/dl) 185±34 190±52 0.89

LDL-cholesterol (mg/dl) 100±23 104±24 0.75

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Genital ulceration 20

Uveitis 10

Skin lesions 32

Arthralgia/arthritis 20 Major vascular involvement 0

Disease duration (years) 5.9

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Table 2. Brachial artery Doppler ultrasound measurements

Basal diameter FMD (%) NID (%)

Patients with Behcet’s disease (n=40) 3.49±0.48 13.34±4.92 16.31±2.45

Control group (n=20) 3.46±0.52 16.36±4.62 20.05±1.57

S 0.867 0.03 0.16

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REFERENCES

1. Bozkurt A, Akpinar O, Uzun S, Akman A, Arslan D, Birand

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