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Prof.Dr. Meral Tunçbilek

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Academic year: 2021

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Prof.Dr. Meral Tunçbilek

ISOMERISM IN DRUG

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Recent Optically Active Drugs

Levamlodipine, also known as levoamlodipine or S-amlodipine is a pharmacologically active enantiomer of amlodipine. Amlodipine belongs to the dihydropyridine group of calcium channel blocker used as an antihypertensive and antianginal agent

(S)-Amlodipine (Levamlodipine)

3-ethyl 5-methyl-2-[(2-aminoethoxymethyl]-4-(2- chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

(3)

S-atenolol is highly active enantiomer than its (R)-enantiomer possessing no activity (S)-atenolol is the more pharmacologically effective form of atenolol.

S(-)atenolol optically pure, which is free of the R(+) enantiomer, is a potent beta-blocking agent in the regulation of heart rate, relieving the symptoms of angina, and reduces blood pressure in individuals

(S)-(−)-Atenolol

(−)-4-[2-Hydroxy-3-[(1-methylethyl) amino]propoxy]benzeneacetamide

(4)

Cetirizine Ketamine Metoprolol Omeprazole Pantoprazole Salbutamol Propranolol Clopidogrel Rabeprazole Citalopram Ibuprofen Ketoprofen Zopiclone Etodolac Escitalopram Nateglinide

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