Prof.Dr. Meral Tunçbilek
ISOMERISM IN DRUG
Recent Optically Active Drugs
Levamlodipine, also known as levoamlodipine or S-amlodipine is a pharmacologically active enantiomer of amlodipine. Amlodipine belongs to the dihydropyridine group of calcium channel blocker used as an antihypertensive and antianginal agent
(S)-Amlodipine (Levamlodipine)
3-ethyl 5-methyl-2-[(2-aminoethoxymethyl]-4-(2- chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
S-atenolol is highly active enantiomer than its (R)-enantiomer possessing no activity (S)-atenolol is the more pharmacologically effective form of atenolol.
S(-)atenolol optically pure, which is free of the R(+) enantiomer, is a potent beta-blocking agent in the regulation of heart rate, relieving the symptoms of angina, and reduces blood pressure in individuals
(S)-(−)-Atenolol
(−)-4-[2-Hydroxy-3-[(1-methylethyl) amino]propoxy]benzeneacetamide
Cetirizine Ketamine Metoprolol Omeprazole Pantoprazole Salbutamol Propranolol Clopidogrel Rabeprazole Citalopram Ibuprofen Ketoprofen Zopiclone Etodolac Escitalopram Nateglinide