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Retinoid N-(1H-benzo[d]imidazol-2-yl)-5,5,8,8-tetramethyl-5,6,7, 8-tetrahydronaphthalene-2-carboxamide induces p21-dependent senescence in breast cancer cells

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Fig. 1. Compound 17 leads to senescence in T47D breast cancer cells. (A) Chemical structure of compound 17
Fig. 3. Comparative analysis of the cytotoxic action of compound 17 and retinoid receptor expression
Fig. 4. Effect of compound 17 on RXR c - or RXR a -silenced cells. MCF-7 breast cancer cells were transiently transfected with (A) siRXR a and (B) siRXR c and scrambled siRNA, and treated with either compound 17 or DMSO

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