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HERBAL TEAS POSSESING STIMULATORY

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(1)

HERBAL TEAS POSSESING STIMULATORY

ACTIVITY ON CENTRAL NERVOUS SYSTEM

(2)

STIMULATION CENTRAL NERVOUS SYSTEM

Especially plants which compounds with phenylethylamine and xanthine groups

Catecholaminergic activity and/or effect on adenosine receptors

(3)

CAFFEINE CONTAINING HERBAL TEAS

 Caffeine intake at high doses;

 Anxiety  Restlessness  Insomnia  Palpitation

 Avoidance of caffeine after regular use may cause constipation due to the laxative effect of caffeine.  In case of abstinence from caffeine intake after a long period may cause headache.

 Shouldn’t be used during pregnancy and lacttion periods.

 Patients suffering from hypertension, gastric ulcer and heart diseases aren’t advised to comsume beverages

(4)

CAFFEINE CONTAINING HERBAL TEAS

Camellia sinensis (tea)

Coffea arabica (coffee)

Paullinia cupana (guarana)

Ilex paraguariensis (mate)

(5)

CAMELLIA SINENSIS

Juvenile leaves

White tea… withered and dried using air flow

Green tea… steamed and dried leaves

Oolong tea … half-fermented leaves

Black tea… fermented leaves

(6)

CAMELLIA SINENSIS

Infusion (≈ %8-12 polyphenol) 3 times a day

Tea-bag teas (1.8-2.2 g/bag) or dried leaves

≈ 3 min. of steeping (longer time of steeping leads to higher tannin content)

Antioxidant activity (the activity of green tea is higher than black tea)

Thermogenic, antithrombotic, diuretic, antidiabetic, antibacterial

(7)

CAMELLIA SINENSIS – DRUG INTERACTIONS

Tannin content may lead to decreased absorbtion of drugs.

Non-selective MAO inhibitors, catechol-O-methyltransferase inhibitors (hypertension risk)

CYP1A2 inhibitors (nausea, tremor or palpitation due to the increase in plasma caffeine

concentration)

CNS stimulants (such as nicotine, amphetamin), selective β-adrenergic receptor agonists and

sempatomimetic drugs

(8)

COFFEA ARABICA (COFFEE)

Roasted and powdered seeds

Infusion/decoction/soluble coffee

Caffeine (0.6-2.2%)

Aromatic compounds are formed during roasting process

Blokade of adenosine receptors

(9)

PAULLINIA CUPANA (GUARANA)

A thick paste of peeled, washed and dried seeds is prepared using water

Paste is put in hot water, sweetened and consumed as tea.

Caffeine, theophylline, theobromine, tannin, saponins

Induce adrenergic activity via blokade of adenosine receptors

Increase in physical/methal capacity

(10)

ILEX PARAGUARIENSIS (MATE)

Dried leaves

Infusion (≈ 2 g drug), 5-10 min.

Xanthine alkaloids (caffeine, theobromine), polyphenols (chlorogenic acid, cafeic acid,

3,4-dicaffeoylquinic acid, 3,5dicaffeoylquinic acid), triterpene saponosides

(11)

THEBROMA CACAO

Semen Cacao

Fermented and dried seeds

Theobromine, caffeine, lipid

(12)

PHENYL ETHYL AMINE GROUP

Herba Ephedrae … Ephedra sinica

In Turkey; E. major, E. campylopoda, E. distachya

 Protoalkaloids (ephedrine, pseudoephedrine, methylephedrine, norephedrine)

 Influence on α- and β- adrenergic receptors… inhibition of adrenaline and noradrenaline intake  Milder effect in comparison with amphetanine

 CNS stimulation, thermogenic, hypertensive, vasoconstructive effects  Overconsumption; insomnia, anxiety, tremor

(13)

HERBS POSSESING ADAPTOGENIC EFFECT

Adaptogen; regulatory agent which increases the resistance of the body against stress

factors, and prevents from damages of these factors by providing adaptation of the

organism.

Increaces resistance to harmfull factors of different physical, chemical, biological natures

Exhibits normalizing effect on body by counteracting/preventing disturbance of stress

Doesn’t cause disturbance to the normal functions of organism

(14)

PANAX GINSENG (GINSENG)

 Dried roots

 Infusion (3 g – 5-10 min.)3-4 times a day/3-4 weeks  Saponosides (ginsenosides)

 Adaptogenic effect

 Patients suffering from heart diseases or diabetes shouldn’t consume.  Consumption with anticoagulants is not advised.

 Concurrent consumption with MAO inhibitors is not advised.

Effects rising from adulteration with less expensive drugs should be considered (Mandragora officinarum, Rauwolfia serpentina, Cola sp.)

(15)

DORSTENIA CONTRAYERVA

 Infusion prepared using roots

 Cardenolides, furanocoumarines, essential oil  Used as stimulant ve adaptogen in folk medicine  Diyaphoretic effect

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