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本研究探討於敗血症

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本研究探討於敗血症 (sepsis) 時,由靜脈注射給予單一劑量麩醯胺 (glutamine, GLN) 對敗血症所引起的器官損傷及存活率之影響。實驗 將雄性 ICR 小白鼠分為三組,一組為控制組 (NC 組 ) 不誘發敗血症

,兩組實驗組皆以盲腸結紮及穿刺手術誘發敗血症後,一組由尾靜脈 注射每公斤體重 0.75 克的 GLN (SG 組 ) ,另一組注射等量生理食鹽 水作對照 (SS 組 ) ,於誘發敗血症後 1, 6, 18, 48 小時犧牲,取全血及 肝、腎、肺組織進行分析並觀察存活率。結果顯示 48 小時存活率 SG 組為 67﹪ ,而 SS 組為 20﹪ ;組織過氧化傷害方面,敗血症後給予 GLN 在 6 、 18 小時可降低各組織骨髓過氧化酶活性、組織脂質過氧 化物 TBARS 濃度以及 nitrotyrosine 生成量,此外 SG 組在 18 小時肺 組織中促細胞凋亡蛋白質 caspase3 活性顯著低於 SS 組,故敗血症後 給予單一劑量 GLN 注射可減少因敗血症引致之組織損傷並增加存活 率。

關鍵字 : 麩醯胺、敗血症、盲腸結紮及穿刺、細胞凋亡

麩醯胺對敗血症小鼠器官損傷及存活率之影響 胡雅梅 李正中 葉松鈴

台北醫學大學 保健營養學研究所

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