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CELL RECEPTORS

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BIO 473

CELL RECEPTORS

9. WEEK

(2)

Major classes of surface (MEMBRAN) receptors for

signaling

G-protein linked receptors

(3)

TWO subclasses of trimeric G-protein-activated signal transduction pathways

Target protein adenylate cyclase cAMP-> PKA

phospholipase C

(4)

IP3 PATHWAY First messenger Second messenger

Cell response

(5)

Second messengers:

IP3 DAG

Ca

(6)

Protein Kinase C phosphorylates target proteins cell growth

regulation of ion channels cytoskeleton

increases cell pH protein secretion

Response 1

(7)

Ca

++

Binds & activates calmodulin

Calmodulin-binding proteins activated (kinases & phosphatases)

Response 2

(8)

cGMP secondary messenger

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