• Sonuç bulunamadı

Combined DNA methylation and gene expression profiling in gastrointestinal stromal tumors reveals hypomethylation of SPP1 as an independent prognostic factor

N/A
N/A
Protected

Academic year: 2021

Share "Combined DNA methylation and gene expression profiling in gastrointestinal stromal tumors reveals hypomethylation of SPP1 as an independent prognostic factor"

Copied!
11
0
0

Yükleniyor.... (view fulltext now)

Tam metin

Şekil

Figure 1. Targeted DNA methylation analysis identified SPP1 as a novel prognostic factor
Figure 2. Bisulfite sequencing of the promoter region of SPP1 con- con-firmed strongest regulation of CpG at position 647, and  pyrose-quencing validated methylation levels of SPP1 compared to Illumina Golden Gate data
Figure 3. Prognostic impact of SPP1 methylation determined by pyrosequencing in 141 primary GISTs, comparing tumors with low (<25%), intermediate (25–75%) and high (>75%) methylation  lev-els (univariate Cox proportional hazards model, p 5 6.6 3 10 2
Figure 4. SPP1 mRNA and protein expression levels are inversely correlated to DNA methylation after decitabine treatment in vitro, and SPP1 activates intracellular signaling cascades in GIST882 cells

Referanslar

Benzer Belgeler

Multinuclear giant cells were seen in the focal areas of the recurrent tumor which were stained nega- tive for CD68 and positive for CD117.. These results were in favor

In whole genom studies comparing the promoter methylation be- tween the GC cell lines infected and non-infected by Epstein-Barr virus, it was observed that, for the examined

Mersin ilinde 2012 ve 2013 yılları arasında intihar orijinli meydana gelen ölüm olgularının sosyodemografik özelliklerinin belirlenmesi amacıyla yapılan bu çalışmada;

Lev Nikolayeviç Gumilëv tarihçi, etnolog ve akademisyen kim- liğinin yanında alan yazında ilgisini Orta Asya Türk Tarihi’ne yo- ğunlaştırmış bir yazar olarak halkların

Next, Spearman's correlation analysis was performed to test whether the 45S rDNA promoter methylation levels in the breast tumor and matched normal samples were correlated with

She is serving as an editorial member of several reputed journals like Journal of Epidemiological Research (JER),Journal of Epidemiology & Community, Journal

Post-translational modifications on histone proteins alter chromatin structure and, consequently, chromatin function... Bhaumik, Smith, and

Bakteri aşılaması ve azot dozları uygulaması yapılan nohut genotiplerinin ardından ekilen mısır bitkisinin kuru madde miktarları daha önce uygulan azot