The Fifth Conference “ Nuclear Science and Its Application”, 14-17 October 2008
CROSSLINKED AS A METHOD OF NEW PROLONGATED ACTION
DRUGS CREATION
A.T. KUSAINOV, K.N. SARSENBAEV. S.D. DZUMAGALBEV JSV ‘Tark nuclear technologies”, Kurchatov, Kazakhstan
Now widespread medical preparates (drugs) consist o f the substances packed into chemically inert carrier. Last serves for protection o f active components against enzymes and address delivery in ill organ. PEG,chitosan, dextran, lipids and several another polymers are used as carrier. Usually bond between drug andpolymer is hydrogen, i.e. not strong. As aresults the complex fast disintegrates in a f blood. Covalent bound is stronger. Usually it creates by directed chemical binding components o f drug. However activation o f the carrier, synthesis o f interm ediate compounds, washing the received complex, removal o f the reacted reagents complicates production and increases cost o f a drug. One o f the cheap ways o f new drugs creation is use o f crosslinking o f drug components (electron beam technology).The crosslinked drugs have all requirements o f a medical preparates new generation as absence o f toxicity after all known ways o f administration, stability (a preparate not inactivates under action endogenous and bacterial ingibitors, proteolytic enzymes), a high level o f adaptability to manufacture from the point o f view o f industrial production, the low cost o f an end-product, at clear efficiency and a p e a t demand, thus, the electron beam technology allows to create drugs with essentially new medical efficiency and safety. One o f advantages o f this method is an opportunity crosslinking several active components to inert carrier As a result activity o f a drug grows, because it simultaneously acts on different metabolic processes. Activity o f separate substances does not decrease, and the possibility to delivery to ill tissue or organ is high. Joint-stock company « Park o f nuclear technologies » would like to finance development on antitubercular and antineoplastic drugs and to make them in Kazakhstan with help the electron accelerator ELU -1 0 .
