2. KAVRAMSAL ÇERÇEVE
2.2. Türk Pop Müziğinde Batı Müziği Etkileri
Nossos resultados também mostraram que injeções bilaterais do agonista de receptores adrenérgicos α2/imidazólicos, moxonidina, no NTS não produziu alteração na ingestão de água induzida por sobrecarga ig de NaCl 2 M (desidratação intracelular), sugerindo que os receptores adrenérgicos α2/imidazólicos do NTS não participam da ingestão de água durante a desidratação intracelular. Estudos imunohistoquímicos demonstraram que o NTS é uma região com muitos neurônios adrenérgicos e que 40 % destes neurônios se projetam para áreas envolvidas com o controle hidroeletrolítico na ponte (NPBL) e áreas prosencefálicas (OSF e hipotálamo) (MICELI et al., 1987, DAY e SIBBALD, 1988, HOCHSTENBACH e CIRIELLO, 1994, HERBERT e FLUGGE, 1995, CIRIELLO et al., 1996, GEERLING e
LOEWY, 2007, RINAMAN, 2010, 2011). Estudos de Andrade e colaboradores (2006) mostraram que a ativação de receptores adrenérgicos α2/imidazólicos, com moxonidina, no NPBL aumenta a ingestão de sódio hipertônico, mas não a ingestão de água, induzida por sobrecarga ig de NaCl 2 M sugerindo a existência de um importante mecanismo inibitório para o controle da ingestão de sódio no NPBL que é desativado pela moxonidina. No entanto, em nossos experimentos não avaliamos a ingestão de sódio, assim, não sabemos qual o envolvimento dos receptores adrenérgicos α2/imidazólicosdo NTS sobre esta ingestão. Desta forma, mais estudos deverão ser realizados para esclarecer esta questão. Ainda no trabalho de Andrade e colaboradores (2006) foi demonstrado que injeções bilaterais de moxonidina no NPBL de animais saciados e não tratados com sobrecarga ig de NaCl 2 M não apresentaram alterações na ingestão de sódio (ANDRADE et al., 2006). Em nossos experimentos também não avaliamos o efeito da injeção bilateral de moxonidina no NTS de animais saciados e normovolêmicos.
Injeções bilaterais de moxonidina no NTS comissural de animais saciados e normovolêmicos promoveram hipotensão e bradicardia (TOTOLA et al., 2013), o que poderia facilitar a ingestão de água induzida por desidratação intracelular, no entanto, não verificamos aumento da ingestão de água após este tratamento em nossos animais. Observamos que os animais que receberam sobrecarga ig de NaCl 2 M tiveram um aumento da PAM sem alterações da FC, assim, pode ser que a resposta de queda da PAM e bradicardia da moxonidina no NTS tenha sido mascarada pelo aumento da PAM causado pela sobrecarga ig de NaCl 2 M e desta forma não verificamos alterações na ingestão de água e sódio induzido por depleção de sódio.
6 Conclusão
Os resultados demonstram que os receptores gabaérgicos GABAA e serotoninérgicos 5- HT2A/2C, mas não adrenérgicos α2/imidazólicos, do NTS podem modificar mecanismos inibitórios que participam do controle da ingestão de água induzida por desidratação intracelular (gavagem NaCl 2 M) e que os receptores serotoninérgicos 5-HT2A/2C do NTS participam do controle da ingestão de água induzida por injeção central de ANG II.
7 Referências
ADACHI, A. Projection of the hepatic vagal nerve in the medulla oblongata. JAutonNervSyst 10:287-293, 1984.
ANDRADE-FRANZE, G.M.; ANDRADE, C.A.; DE LUCA, L.A., JR.; DE PAULA, P.M.; COLOMBARI, D.S.; MENANI, J.V. Lesions in the central amygdala impair sodium intake induced by the blockade of the lateral parabrachial nucleus. Brain research 1332:57-64, 2010a.
ANDRADE-FRANZE, G.M.; ANDRADE, C.A.; DE LUCA, L.A., JR.; DE PAULA, P.M.; MENANI, J.V. Lateral parabrachial nucleus and central amygdala in the control of sodium intake. Neuroscience 165:633-641, 2010b.
ANDRADE, C.A.; BARBOSA, S.P.; DE LUCA, L.A., JR.; MENANI, J.V. Activation of alpha2-adrenergic receptors into the lateral parabrachial nucleus enhances NaCl intake in rats. Neuroscience 129:25-34, 2004.
ANDRADE, C.A.; DE LUCA, L.A., JR.; COLOMBARI, D.S.; MENANI, J.V. Alpha2- adrenergic activation in the lateral parabrachial nucleus induces NaCl intake under conditions of systemic hyperosmolarity. Neuroscience 142:21-28, 2006.
ANDRADE, C.A.; MARGATHO, L.O.; ANDRADE-FRANZE, G.M.; DE LUCA, L.A., JR.; ANTUNES-RODRIGUES, J.; MENANI, J.V. Moxonidine into the lateral parabrachial nucleus reduces renal and hormonal responses to cell dehydration. Neuroscience 208:69-78, 2012.
ANDRADE, C.A.; OLIVEIRA, L.B.; MARTINEZ, G.; SILVA, D.C.; DE LUCA, L.A., JR.; MENANI, J.V. Involvement of forebrain imidazoline and alpha(2)-adrenergic receptors in the antidipsogenic response to moxonidine. Annals of the New York Academy of Sciences 1009:262-264, 2003.
ANTUNES-RODRIGUES, J.; ELIAS, L.L.K.; CASTRO, M.; DE LUCA, L.A., J.R.; VIVAS, L.M.; MENANI, J.V. Regulação do Balanço Hidroeletrolítico. In Guanabara Koogan (ed.) Fisiologia 3ª Edição, p.1119-1136, 2008.
BATTEN, T.F.; GAMBOA-ESTEVES, F.O.; SAHA, S. Evidence for peptide co-transmission in retrograde- and anterograde-labelled central nucleus of amygdala neurones projecting to NTS. Auton Neurosci 98:28-32, 2002.
BHUIYAN, M.E.; WAKI, H.; GOURAUD, S.S.; TAKAGISHI, M.; CUI, H.; YAMAZAKI, T.; KOHSAKA, A.; MAEDA, M. Complex cardiovascular actions of alpha-adrenergic receptors expressed in the nucleus tractus solitarii of rats. Experimental physiology 94:773-784, 2009.
BLANCH, G.T.; FREIRIA-OLIVEIRA, A.H.; COLOMBARI, E.; MENANI, J.V.; COLOMBARI, D.S. Lesions of the commissural subnucleus of the nucleus of the solitary tract increase isoproterenol-induced water intake. BrazJMedBiolRes 40:1121- 1127, 2007.
BLANCH, G.T.; FREIRIA-OLIVEIRA, A.H.; MURPHY, D.; PAULIN, R.F.; ANTUNES- RODRIGUES, J.; COLOMBARI, E.; MENANI, J.V.; COLOMBARI, D.S. Inhibitory mechanism of the nucleus of the solitary tract involved in the control of cardiovascular, dipsogenic, hormonal, and renal responses to hyperosmolality. AmJPhysiol RegulIntegrComp Physiol 304:R531-R542, 2013.
BOOTH, R.E.; JOHNSON, J.P.; STOCKAND, J.D. Aldosterone. Advances in physiology education 26:8-20, 2002.
BOURQUE, C.W.; OLIET, S.H. Osmoreceptors in the central nervous system. AnnuRevPhysiol 59:601-619, 1997.
BOWERY, N.G.; HUDSON, A.L.; PRICE, G.W. GABAA and GABAB receptor site distribution in the rat central nervous system. Neuroscience 20:365-383, 1987.
CALLERA, J.C.; BONAGAMBA, L.G.; NOSJEAN, A.; LAGUZZI, R.; MACHADO, B.H. Activation of GABAA but not GABAB receptors in the NTSblocked bradycardia of chemoreflex in awake rats. The American journal of physiology 276:H1902-1910, 1999.
CALLERA, J.C.; BONAGAMBA, L.G.; NOSJEAN, A.; LAGUZZI, R.; MACHADO, B.H. Activation of GABA receptors in the NTS of awake rats reduces the gain of baroreflex bradycardia. Autonomic neuroscience : basic & clinical 84:58-67, 2000.
CALLERA, J.C.; COLOMBARI, E.; DE LUCA, L.A., JR.; MENANI, J.V. The bradycardic and hypotensive responses to serotonin are reduced by activation of GABAA receptors in the nucleus tractus solitarius of awake rats. BrazJMedBiolRes 38:1123-1131, 2005a.
CALLERA, J.C.; OLIVEIRA, L.B.; BARBOSA, S.P.; COLOMBARI, D.S.; DE LUCA, L.A., JR.; MENANI, J.V. GABA(A) receptor activation in the lateral parabrachial nucleus induces water and hypertonic NaCl intake. Neuroscience 134:725-735, 2005b.
CATELLI, J.M.; GIAKAS, W.J.; SVED, A.F. GABAergic mechanisms in nucleus tractus solitarius alter blood pressure and vasopressin release. Brain research 403:279-289, 1987.
CIRIELLO, J.; ROSAS-ARELLANO, M.P.; SOLANO-FLORES, L.P. Direct projections to subfornical organ from catecholaminergic neurons in the caudal nucleus of the solitary tract. Brain research 726:227-232, 1996.
COLOMBARI, D.S.; MENANI, J.V.; JOHNSON, A.K. Forebrain angiotensin type 1 receptors and parabrachial serotonin in the control of NaCl and water intake. AmJPhysiol 271:R1470-R1476, 1996.
COLOMBARI, E.; SATO, M.A.; CRAVO, S.L.; BERGAMASCHI, C.T.; CAMPOS, R.R., JR.; LOPES, O.U. Role of the medulla oblongata in hypertension. Hypertension 38:549-554, 2001.
COTTLE, M.K. Degeneration Studies of Primary Afferents of Ixth and Xth Cranial Nerves in the Cat. The Journal of comparative neurology 122:329-345, 1964.
DAVID, R.B.; RONCARI, C.F.; LAUAR, M.R.; VENDRAMINI, R.C.; ANTUNES- RODRIGUES, J.; MENANI, J.V.; DE LUCA, L.A., JR. Sodium intake, brain c-Fos protein and gastric emptying in cell-dehydrated rats treated with methysergide into the lateral parabrachial nucleus. Physiology & behavior 151:111-120, 2015.
DAY, T.A.; SIBBALD, JR. Solitary nucleus excitation of supraoptic vasopressin cells via adrenergic afferents. The American journal of physiology 254:R711-716, 1988.
DE GOBBI, J.I.F.; DE LUCA, L.A., JR.; MENANI, J.V. Serotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intake. Brain Res 880:131-138, 2000.
DE LUCA, L.A., JR.; PEREIRA-DERDERIAN, D.T.; VENDRAMINI, R.C.; DAVID, R.B.; MENANI, J.V. Water deprivation-induced sodium appetite. Physiology & behavior 100:535-544, 2010.
DE LUCA, L.A., JR.; BARBOSA, S.P.; MENANI, J.V. Brain serotonin blockade and paradoxical salt intake in rats. Neuroscience 121:1055-1061, 2003.
DE OLIVEIRA, L.B.; CALLERA, J.C.; DE LUCA, L.A., JR.; COLOMBARI, D.S.; MENANI, J.V. GABAergic mechanisms of the lateral parabrachial nucleus on sodium appetite. Brain research bulletin 73:238-247, 2007.
DE OLIVEIRA, L.B.; DE LUCA, L.A., JR.; MENANI, J.V. Moxonidine and central alpha2 adrenergic receptors in sodium intake. Brain research 993:177-182, 2003.
FITZSIMONS, J.T. Angiotensin, thirst, and sodium appetite. Physiological reviews 78:583- 686, 1998.
FREIRIA-OLIVEIRA, A.H.; BLANCH, G.T.; PEDRINO, G.R.; CRAVO, S.L.; MURPHY, D.; MENANI, J.V.; COLOMBARI, D.S. Catecholaminergic neurons in the comissural region of the nucleus of the solitary tract modulate hyperosmolality-induced responses. American journal of physiology Regulatory, integrative and comparative physiology 309:R1082-1091, 2015.
GALAVERNA, O.; DE LUCA, L.A., JR.; SCHULKIN, J.; YAO, S.Z.; EPSTEIN, A.N. Deficits in NaCl ingestion after damage to the central nucleus of the amygdala in the rat. Brain research bulletin 28:89-98, 1992.
GASPARINI, S.; GOMIDE, J.M.; ANDRADE-FRANZE, G.M.; TOTOLA, L.T.; DE LUCA, L.A., JR.; COLOMBARI, D.S.; DE PAULA, P.M.; MOREIRA, T.S.; MENANI, J.V. Facilitation of sodium intake by combining noradrenaline into the lateral parabrachial nucleus with prazosin peripherally. Pharmacology, biochemistry, and behavior 111:111-119, 2013.
GAUDIN-CHAZAL,G.; PORTALIER, P.; BARRIT, M. C.; PUIZILLOUT, J. J. Serotonin- like immunoreactivity in paraffin-sections of the nodose ganglia of the cat. Neurosci. Lett. 33:169–172, 1982.
GEERLING, J.C.; LOEWY, A.D. Sodium deprivation and salt intake activate separate neuronal subpopulations in the nucleus of the solitary tract and the parabrachial complex. The Journal of comparative neurology 504:379-403, 2007.
GUYENET, P.G. The sympathetic control of blood pressure. Nature reviews Neuroscience 7:335-346, 2006.
HABER, E. George C. Griffith lecture. The role of renin in normal and pathological cardiovascular homeostasis. Circulation 54:849-861, 1976.
HABERICH, F.J. Osmoreception in the portal circulation. FedProc 27:1137-1141, 1968. HALSELL, C.B.; TRAVERS, S.P.; TRAVERS, J.B.; Ascending and descending projections
from the rostral nucleus of the solitary tract originate from separate neuronal populations. Neuroscience 72:185-197, 1996.
HERBERT, H.; FLUGGE, G. Distribution of alpha 2-adrenergic binding sites in the parabrachial complex of the rat. Anatomy and embryology 192:507-516, 1995.
HERBERT, H.; MOGA, M.M.; SAPER, C.B. Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. JComp Neurol 293:540-580, 1990.
HOCHSTENBACH, S.L.; CIRIELLO, J. Effects of plasma hypernatremia on nucleus tractus solitarius neurons. The American journal of physiology 266:R1916-1921, 1994.
HOSFORD, P.S.; MILLAR, J.; RAMAGE, A.G. Cardiovascular afferents cause the release of 5-HT in the nucleus tractus solitarii; this release is regulated by the low-(PMAT) not the high-affinity transporter (SERT). J Physiol. 593(7):1715-29, 2015.
HOSOMI, H.; MORITA, H. Hepatorenal and hepatointestinal reflexes in sodium homeostasis. News Physiological Science 11:103-107, 1996.
JALOWIEC, J.E. Sodium appetite elicited by furosemide: effects of differential dietary maintenance. Behavioral biology 10:313-327, 1974.
JOHNSON, A.K. The sensory psychobiology of thirst and salt appetite. Medicine and science in sports and exercise 39:1388-1400, 2007.
JOHNSON, A.K.; CUNNINGHAM, J.T.; THUNHORST; R.L. Integrative role of the lamina terminalis in the regulation of cardiovascular and body fluid homeostasis. Clinical and experimental pharmacology & physiology 23:183-191, 1996.
JOHNSON, A.K.; THUNHORST, R.L. The neuroendocrinology of thirst and salt appetite: visceral sensory signals and mechanisms of central integration. Frontiers in neuroendocrinology 18:292-353, 1997.
KIMURA, E.H.; OLIVEIRA, L.B.; COLOMBARI, D.S.; DE LUCA, L.A., JR.; MENANI, J.V.; CALLERA, J.C. Sodium intake by hyperosmotic rats treated with a GABA(A) receptor agonist into the lateral parabrachial nucleus. Brain research 1190:86-93, 2008.
KRALY, F.S.; KIM, Y.M.; TRIBUZIO, R.A. Renal nerve transection inhibits drinking elicited by eating and by intragastric osmotic loads in rats. Physiol Behav 58:1129- 1136, 1995.
KVETNANSKY, R.; SABBAN, E.L.; PALKOVITS, M. Catecholaminergic systems in stress: structural and molecular genetic approaches. Physiol Rev 89:535-606, 2009.
LANCA, A.J.; VAN DER KOOY, D. A serotonin-containing pathway from the area postrema to the parabrachial nucleus in the rat. Neuroscience 14:1117-1126, 1985.
LASITER, P.S.; KACHELE, D.L. Organization of GABA and GABA-transaminase containing neurons in the gustatory zone of the nucleus of the solitary tract. Brain Res Bull 21:623-636, 1988
LORENZ, W.; LOMASNEY, J.W.; COLLINS, S.; REGAN, J.W.; CARON, M.G.; LEFKOWITZ, R.J.; Expression of three alpha 2-adrenergic receptor subtypes in rat tissues: implications for alpha 2 receptor classification. Molecular pharmacology 38:599-603, 1990.
MACHADO, B.H. Neurotransmission of the cardiovascular reflexes in the nucleus tractus solitarii of awake rats. Annals of the New York Academy of Sciences 940:179-196, 2001.
MACHADO, B.H.; BONAGAMBA, L.G. Microinjection of L-glutamate into the nucleus tractus solitarii increases arterial pressure in conscious rats. Brain research 576:131- 138, 1992.
MALEY, B.E. Immunohistochemical localization of neuropeptides and neurotransmitters in the nucleus solitarius. Chen Senses 21:367-376, 1996.
MEELEY, M.P.; RUGGIERO, D.A.; ISHITSUKA, T.; REIS, D.J. Intrinsic gamma- aminobutyric acid neurons in the nucleus of the solitary tract and the rostral ventrolateral medulla of the rat: an immunocytochemical and biochemical study. Neuroscience letters 58:83-89, 1985.
MENANI, J.V.; BARBOSA, S.P.; DE LUCA, L.A., JR.; DE GOBBI, J.I.; JOHNSON, A.K. Serotonergic mechanisms of the lateral parabrachial nucleus and cholinergic-induced sodium appetite. American journal of physiology Regulatory, integrative and comparative physiology 282:R837-841, 2002.
MENANI, J.V.; COLOMBARI, D.S.; BELTZ, T.G.; THUNHORST, R.L.; JOHNSON, A.K. Salt appetite: interaction of forebrain angiotensinergic and hindbrain serotonergic mechanisms. Brain Res 801:29-35, 1998a.
MENANI, J.V.; DE LUCA, L.A.,JR.; JOHNSON, A.K. Lateral parabrachial nucleus serotonergic mechanisms and salt appetite induced by sodium depletion. AmJPhysiol 274:R555-R560, 1998b.
MENANI, J.V.; DE LUCA, L.A., JR.; JOHNSON, A.K. Role of the lateral parabrachial nucleus in the control of sodium appetite. American journal of physiology Regulatory, integrative and comparative physiology 306:R201-210, 2014.
MENANI, J.V.; JOHNSON, A.K. Lateral parabrachial serotonergic mechanisms: angiotensin- induced pressor and drinking responses. AmJPhysiol 269:R1044-R1049, 1995.
MENANI, J.V.; SATO, M.A.; HAIKEL, L.; VIEIRA, A.A.; DE ANDRADE, C.A.; DA SILVA, D.C.; RENZI, A.; DE LUCA, L.A., JR. Central moxonidine on water and NaCl intake. Brain research bulletin 49:273-279, 1999.
MENANI, J.V.; THUNHORST, R.L.; JOHNSON, A.K. Lateral parabrachial nucleus and serotonergic mechanisms in the control of salt appetite in rats. AmJPhysiol 270:R162- R168, 1996.
MENEZES, M.F.; BARBOSA, S.P.; ANDRADE, C.A.; MENANI, J.V.; DE PAULA, P.M. Purinergic mechanisms of lateral parabrachial nucleus facilitate sodium depletion- induced NaCl intake. Brain Res 1372:49-58, 2011.
MERAHI, N.; ORER, H.S.; LAPORTE, A.M.; GOZLAN, H.; HAMON, M.; LAGUZZI, R. Baroreceptor reflex inhibition induced by the stimulation of serotonin3 receptors in the nucleus tractus solitarius of the rat. Neuroscience 46:91-100, 1992.
MICELI, M.O.; POST, C.A.; VAN DER KOOY, D. Catecholamine and serotonin colocalization in projection neurons of the area postrema. Brain research 412:381-385, 1987.
NOZAKI, P.N.; PEREIRA, D.T.; MOURA, F.V.; MENANI, J.V.; DE LUCA, L.A. Ingestion of hypertonic NaCl vs. palatable drinks by sodium-depleted rats. Physiology & behavior 75:443-448, 2002.
NOSJEAN, A.; COMPOINT, C.; BUISSERET-DELMAS, C.; ORER, H. S.; MERAHI, N.; PUIZILLOUT, J. J.; LAGUZZI, R. Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius: An immunohistochemical and double labeling study in the rat. Neurosci. Lett. 114:22–26, 1990
OGIHARA, C.A.; SCHOORLEMMER, G.H.; COLOMBARI, E.; SATO, M.A. Changes in sodium appetite evoked by lesions of the commissural nucleus of the tractus solitarius. BrazJMedBiolRes 42:561-566, 2009.
OHMAN, L.E.; JOHNSON, A.K. Brain stem mechanisms and the inhibition of angiotensin- induced drinking. AmJPhysiol 256:R264-R269, 1989.
PALKOVITS, M.; ZABORSZKY, L. Neuroanatomy of central cardiovascular control. Nucleus tractus solitarii: afferent and efferent neuronal connections in relation to the baroreceptor reflex arc. ProgBrain Res 47:9-34, 1977.
PAXINOS, G.; WATSON, C. The Rat Brain: In Stereotaxic Coordinates: Academic Press, Incorporated, 1998.
PEREIRA, D.T.; VENDRAMINI, R.C.; DAVID, R.B.; NOZAKI, P.N.; MENANI, J.V.; DE LUCA, L.A., JR. Isotonic NaCl intake by cell-dehydrated rats. Physiol Behav 76:501- 505, 2002.
PICKEL, V.M.; CHAN, J.; MILNER, T.A. Cellular substrates for interactions between neurons containing phenylethanolamine N-methyltransferase and GABA in the nuclei of the solitary tracts. The Journal of comparative neurology 286:243-259, 1989.
PICKEL, V.M.; VAN BOCKSTAELE, E.J.; CHAN, J.; CESTARI, D.M. Amygdala efferents form inhibitory-type synapses with a subpopulation of catecholaminergic neurons in the rat Nucleus tractus solitarius. J Comp Neurol 362:510-523, 1995.
RICARDO, J.A.; KOH, E.T. Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat. Brain Res 153:1-26, 1978.
RINAMAN, L. Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure. Brain research 1350:18- 34, 2010.
RINAMAN, L. Hindbrain noradrenergic A2 neurons: diverse roles in autonomic, endocrine, cognitive, and behavioral functions. American journal of physiology Regulatory, integrative and comparative physiology 300:R222-235, 2011.
ROWLAND, N.E.; FREGLY, M.J. Repletion of acute sodium deficit in rats drinking either low or high concentrations of sodium chloride solution. The American journal of physiology 262:R419-425, 1992.
SAHA, S.; BATTEN, T.F.; HENDERSON, Z. A GABAergic projection from the central nucleus of the amygdala to the nucleus of the solitary tract: a combined anterograde tracing and electron microscopic immunohistochemical study. Neuroscience 99:613- 26, 2000.
SAKAI, R.R.; FINE, W.B.; EPSTEIN, A.N.; FRANKMANN, S.P. Salt appetite is enhanced by one prior episode of sodium depletion in the rat. Behavioral neuroscience 101:724- 731, 1987.
SAKAI, R.R.; FRANKMANN. S.P.; FINE, W.B.; EPSTEIN, A.N. Prior episodes of sodium depletion increase the need-free sodium intake of the rat. Behavioral neuroscience 103:186-192, 1989.
SAKAI, R.R.; MA, L.Y.; ZHANG, D.M.; MCEWEN, B.S.; FLUHARTY, S.J. Intracerebral administration of mineralocorticoid receptor antisense oligonucleotides attenuate adrenal steroid-induced salt appetite in rats. Neuroendocrinology 64:425-429, 1996. SAPER, C.B.; REIS, D.J.; JOH, T. Medullary catecholamine inputs to the anteroventral third
SATO, M.A.; YADA, M.M.; RENZI, A.; CAMARGO, L.A.; SAAD, W.A.; MENANI, J.V.; DE LUCA, L.A., J.R. Antagonism of clonidine injected intracerebroventricularly in different models of salt intake. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica [et al] 29:1663-1666, 1996.
SCHAFFAR, N.; KESSLER, J. P.; BOSLER, O.; JEAN, A. Central serotonergic projections to the nucleus tractus solitarii: Evidence from a double labelling study in the rat. Neuroscience 26:951–958, 1988.
SCHREIHOFER, A.M.; STRICKER, E.M.; SVED, A.F. Nucleus of the solitary tract lesions enhance drinking, but not vasopressin release, induced by angiotensin. AmJPhysiol RegulIntegrComp Physiol 279:R239-R247, 2000.
STANTON, B.A.; KOEPPEN, B.M. Controle da osmolaridade e do volume dos fluidos corporais. In: BERNE, R.M.; LEVY, M.N.; KOEPPEN, B.M.; STANTON, B.A. Fisiologia 6ª Edição. Ed. Elsevier, Rio de Janeiro, RJ, (2009), p.597-620.
SEVOZ, C.; HAMON, M.; LAGUZZI, R. Medullary pathways of cardiovascular responses to 5-HT2 and 5-HT3 receptor stimulation in the rat nucleus tractus solitarius. Neuroreport 7:1965-1969, 1996.
SPIELMAN, W.S.; DAVIS, J.O. The renin-angiotensin system and aldosterone secretion during sodium depletion in the rat. Circulation research 35:615-624, 1974.
STEINBUSCH, H.W. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 6:557-618, 1981.
STRICKER, E.M.; CALLAHAN, J.B.; HUANG, W.; SVED, A.F. Early osmoregulatory stimulation of neurohypophyseal hormone secretion and thirst after gastric NaCl loads. AmJPhysiol RegulIntegrComp Physiol 282:R1710-R1717, 2002.
STRICKER, E.M.; VERBALIS, J.G. Central inhibition of salt appetite by oxytocin in rats. RegulPept 66:83-85, 1996.
TER HORST, G. J.; STREEFLAND, C. Ascending projections of the solitary tract nucleus. In: BARRACO, I. R. A. (Ed.). Nucleus of the solitary tract. Boca Raton, FL: CRC Press, 1994.p.93-103.
THOR, K. B.; HELKE, C. J. Serotonin- and substance P-containing projections to the nucleus tractus solitarii of the rat. J. Comp. Neurol. 265:275–293, 1987.
THOR, K. B., HILL, K. B., HARROD, C., AND HELKE, C. J. Immunohistochemical and biochemical analysis of serotonin and substance P colocalisation in the nucleus tractus solitarii and associated afferent ganglia of the rat. Synapse 2:225–231, 1988.
TOTOLA, L.T.; ALVES, T.B.; TAKAKURA, A.C.; FERREIRA-NETO, H.C.; ANTUNES, V.R.; MENANI, J.V.; COLOMBARI, E.; MOREIRA, T.S. Commissural nucleus of the solitary tract regulates the antihypertensive effects elicited by moxonidine. Neuroscience 250:80-91, 2013.
VAN DER KOOY, D.; KODA, L.Y. Organization of the projections of a circumventricular organ: the area postrema in the rat. JComp Neurol 219:328-338, 1983.
VENDRAMINI, R.C.; PEREIRA, D.T.; BORELLA, T.L.; MENANI, J.V.; DE LUCA, L.A., JR. Damage to the central amygdala produces differential encephalic c-fos expression in the water deprivation-partial rehydration protocol. Brain research 1304:80-89, 2009.
VERBALIS, J.G. Disorders of body water homeostasis. Best practice & research Clinical endocrinology & metabolism 17:471-503, 2003.
WOLF, W.A.; KUHN, D.M.; LOVENBERG, W. Blood pressure responses to local application of serotonergic agents in the nucleus tractus solitarii. European journal of pharmacology 69:291-299, 1981.
YADA, M.M.; DE PAULA, P.M.; MENANI, J.V.; DE LUCA, L.A., JR. Central alpha- adrenergic agonists and need-induced 3% NaCl and water intake. PharmacolBiochemBehav 57:137-143, 1997a.
YADA, M.M.; DE PAULA, P.M.; MENANI, J.V.; RENZI, A.; CAMARGO, L.A.; SAAD, W.A.; DE LUCA, L.A., JR. Receptor-mediated effects of clonidine on need-induced 3% NaCl and water intake. Brain ResBull 42:205-209, 1997b.