Radyasyona maruziyetten sonra oluşan kronik faz, submukozal damarların inflamasyonu, daralması ve tıkanması sonucunda hasarlanmasıyla ilişkilidir. Bu çalışma kronik yan etkilerin derecesinin, akut bulgularla bağlantılı hipotezi üzerine kurulmuştur. Çünkü dokuların erken zamanlı iyonize radyasyona yanıtı sonraki inflamatuar olaylara dokuları daha duyarlı hale getirir.Bu nedenle, radyasyona bağlı oksidatif hasar düzeltilerek, erken zamanlı radyasyon hasarından bağırsağı korumak büyük önem taşımaktadır.
Radyoterapi abdominopelvik tümörlerin tedavisinde önemli bir tedavi yöntemidir ancak normal hücreler üzerinde, akut ve gecikmiş yan etkiler tedavinin etkisini sınırlayabilir. Bizim bulduğumuz sonuçlar, antioksidan, anti-inflamatuar ve proliferatif etkileri olan erdosteinin, ince bağırsakta radyasyon toksisitesine karşı koruma sağlayabileceğini düşündürmüştür. Bu konuda deneysel olarak daha uzun süreli ve klinik çalışmalara ihtiyaç vardır.
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