3. GELENEKSEL EĞİTİM
3.4. İlk Sivil Okullar
1- A administração do fucoidam total de Fucus vesiculosus reduziu a inflamação na fase aguda da artrite induzida por zymosan;
2- O fucoidam total de Fucus vesiculosus apresentou uma atividade antiinflamatória semelhante ao parecoxib na fase aguda da artrite induzida por zymosan;
3- Não ocorreu alterações qualitativas de GAG na cartilagem articular de ratos na fase aguda da artrite induzida por zymosan.
REFERÊNCIAS
ABRAMSON, S. B. et al. NO and inflammatory mediators in the perpetuation of osteoarthritis. Curr. Rheumatol. Resp. v.3, p.535-541, 2001.
AFELTRA, A. Treatment of rheumatoid arthritis: new therapeutic approaches with biological agents. Curr. Drug Target Immune Endocr. Metabol. Disord. V.1, p.45-65, 2001.
ALBERS, J.M.C. et al. Treatment strategy, disease activity, and outcome in four cohorts of patients with early rheumatoid arthritis. Ann. Rheum. Dis.v.60, p.453-458, 2001.
ALVAREZ, B. et al. Kinetics of peroxynitrite reaction with amino acids and human serum albumin. J. Biol. Chem. v.274, p.842-848,1999.
ALWAYN, I. P. et al. Inhibition of platelet aggregation in baboons: therapeutic implications for xenotransplantion.Xenotransplantion, v.7, p.247-257, 2000.
ANGSTWURM K. et al., Fucoidan, a polysaccharide inhibiting leukocyte rolling, attenuates inflammatory responses in experimental pneumococcal meningitis in rats. Neurosci Lett., v.191,p.1-4, 1995.
ARNETT, F. C. The American Rheumatism Association-revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. V.31, p.315-322, 1988.
BECKER, E.T. The short and happy life of neutrophil activation. J. Leukoc. Biol., v.47, p.378-389, 1990.
BECKMAN, J.S., et al. Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol. Chem. Hoppe-Seyler. V. 375, p. 81-88, 1994.
BENSOUYAD, A. et al. Concentrations of glycosaminoglycans in fluids and their relation with immunological and inflammatory in rheumatoid arthritis. Ann. Rheum. Dis., v.49, n.5, p.301-307, 1990.
BERTEAU, O.; MULLOY, B. Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. Glycobiology. V.13, p.29R-40R, 2003.
BEVILACQUA, M.P.Endotelial-leukocyte adhesion molecules. Annual Review of Immunology, V.11, p. 767-804,1993.
BILAN, M. I. et al. Structure of a fucoidan from the brown seaweed Fucus evanescens C. Ag. Carbohyd. Res., v. 337, p. 719-730, 2002.
BOISSON- VIDAL, C.et al. Biological activities of polysaccharides from marine algae. Drugs of the future, v.20, p.1237-1249, 1995.
BRAHN, E. Animals models of rheumatoid arthritis: clues to etiology and treatment. Clin. Orthop., v.265, p. 42-53, 1991.
BEZERRA, M.M. et al., Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis. British Journal of Pharmacology, v.141, p.172-182, 2004.
BROWN, G.D.; GORDON, S. Immune recognition: a new receptor for E glucans. Nature, p.413-436, 2001.
CHANG, Y. H., PEARSON, C. M.; ABE, C. Adjuvant polyarthritis IV: induction by a synthetic adjuvant: immunologic, histopathologic and other studies. Arthritis Rheum.,v. 23, p. 62-71, 1980.
CHAN, C.C.; RODGER, I.W. Selective COX-2 inhbitors as potential therapeutic agents for inflammatory diseases. Adv. Exp. Med. Biol. V.407, p.157-161, 1997.
CHATHAM, W.W. et al. Degradation of human articular cartilage by neutrophils in synovial fluid. Arthritis and Rheumatism. V.36, p.51-58, 1993.
CHEVOLOT, L. et al. A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae. Carbohyd. Res., v. 330, p. 529 - 535, 2001.
CHIZHOV, A. O. et al. study of fucoidan from the brown seaweed Chorda filum. Carbohyd. Res., v. 320, p. 108-119, 1999.
CHIKANZA, I.C.; KINGSLEY, G.; PANAYI, G.S. Peripheral blood and synovial fluid monocyte expression of interleukin 1(alpha) and 1 (beta) during active rheumatoid arthritis. J. Rheumatol. V.22; p.600-606, 1995.
CHOY, E.H.; PANAYI, G.S. Cytokine pathways and joint inflammation in rheumatoid arthritis. N. Engl. J. Med. V.344, p.907-916, 2001.
CONCHIE, J.; PERCIVAL, E. G. V. – Fucoidin. Part II. The hydrolysis of a mrthylated fucoidin prepared from Fucus vesiculosus. J. Chem. Soc., p. 827-832, 1950.
CRILLY, A. et al. Genotyping for disease associated HLA DR beta 1 alleles and the need for early joint surgery in rheumatoid arthritis: a quantitative evaluation. Ann Rheum. Dis. V. 58, p.114-117, 1999.
DIETRICH, C. P.; DIETRICH, S. M. C. Electrophoretic behavior of acidic
mucopolysaccharides in diamine buffers. Annal. Biochem. V.70, p.645-647, 1976.
DOAN, T.; MASSAROTTI, E. Rheumatoid arthritis: An overview of new and emerging therapies. Journal of Clinical Pharmacology. V.45, p.751-762, 2005.
DUARTE, M. E. R.; CARDOSO, M. A.; NOSEDA, M. D.; CEREZO, A. S. – Structural studies on fucoidans from the brown seaweed Sargassum stenephyllum. Carbohyd. Res., v. 333, p. 281-293, 2001.
DÜRIG, J. et al. - Anticoagulant fucoidan fractions from Fucus vesiculosos induce platelet activation in vitro. Throbosis Research, 85(6): 479-491, 1997.
DUMONDE, D.C.; GLYNN, L.E. The production of arthritis in rabbits by na immunological reaction to fibrin. Br. J. Exp. Pathol. V. 43, p. 373-382, 1962.
ELLOUALI, M.; BOISSON-VIDAL, C.; DURAND, P.; J. JOZEFONVISCZ Antitumor activity of low molecular weight fucan extraceted from brown seaweed Ascophyllum nodosum. Anticancer Res., v. 13, p. 2011-2019, 1993.
FELDMAN, M.; MAINI, R.N. The Role of cytokines in the pathogenesis of rheumatoid arthritis. Rheumatology. V.38, p.3-7, 1999.
FOSANG, A. J. et al. Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase derived aggrecan fragments: detection of fragments in human synovial fluids. Biochem. J. p.310-337, 1995.
FURST, D.E. et al. Update consensus statement on tumor necrosis factor blocking agents for the treatment of rheumatoid arthritis. Ann. Rheum. Dis. V.59, p.1-12, 2000.
GADÓ, K.; GLIGER, G. Zymosan inflammation: a new method suitable for evaluating new anti-inflammatory drugs. Agents Actions. V.32, p.119-121, 1991.
GEGOUT, P. et al. Characterization of zymosan-induced arthritis in the rat: effects on joint inflammation and cartilage metabolism. Life Sci., v.55, n.17, p.321-326, 1994.
GEGOUT, P. et al. Zymosan induced arthritis in rats II. Effects of anti-inflammatory drugs. Life Sci., v.56, p. 389-394, 1995.
GOLDBACH-MANSKY, R. et al. Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Research. V.2, p.236-243, 2000.
GRANGER,D. L. et al. Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction. Methodos Enzymol. V.268, p.142-151,1996.
GRANERT, C. et al. Inhibition of leukocyte rolling with polysaccharides fucoidan prevents pleocytosis in experimental meningitis in the rabbit. J. Clin. Invest., V.93, p.929-936,1994.
GUIDE FOR THE CARE AND USE OF LABORATORY ANIMALS. (DREW Publication), Bethesda, MD. USA, 1980.
HARDY, M.M. et al. Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants. Arthritis Rheum. V.46, p.789-803, 2002
HARRIS Jr. E. D. Rheumatoid arthritis. Pathophysiology and implications for therapy. N.Engl. J. Med. V.322, n.18, p.1277-1289, 1990.
HARRIS Jr. E. D. Etiology and pathogenesis of rheumatoid arthritis. In Kelly, W. N. textbook of Rheumatology, 4 edition WB Soundres Co. Philadelphia, USA, p.833-873, 1993.
HARRIS, R.C. et al. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J. Clin.Investig. v.94, p.2504-2510, 1994.
HAWKEY, C. J. Non-steroidal anti-inflammatory drugs and pepsis ulcers. BMJ. V.300, p.278-284, 1990.
HERING, T.M. et al. Modulation of extracellular matrix gene expression in bovine high- density chondrocyte cultures by ascorbic acid and enzymatic ressuspension. Arch. Biochem. Biophys. V.314, p.90-98, 1994.
HOSHIRO, T., HAYASHI, T., HAYASHI, K., HAMADA, J., LEE, J. B. & SANKAWA, U. – An antiviral active sulfated polysaccharide from Sargassum horneri (Tuner) C.
AGARDH. Biol. Pharm. Bull.,v. 21, p. 730-734, 1998.
HEYMER, B.; SPANEL, R.; HFERKAMP, O. Experimental models of arthritis. Curr. Top. Pathol. V. 71, p.123-152, 1982.
HOOZEMANS, J.J. et al. Interleukin-1 beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer s disease. Exp. Gerontol. V.36, p.559-570, 2001.
JERONIMO, S.M.B.; DIETRICH, C.P.; NADER, H.B. Structure of sulfated
glycosaminoglycans synthesized during the ontogeny of the mollusc Pomacea sp. Comp. Biochem. Physiol. ,. B. 93B: 899-903, 1989.
JUNQUEIRA, L.C.U.; CARNEIRO, J. Histologia básica. 9a. ed., Rio de Janeiro:Guanabara Koogan, 1995.
KANG, R.Y. et al. Expression of COX 2 in human and an animal model of rheumatoid arthritis. Br. J. Rheumatol. V.35, p.711-718, 1996.
KEYSTONE; E. C. et al. Zymosan-induced arthritis: a model of chronic proliferative arthritis following activation of the alternative pathway of complement. Arthritis Rheum. V.20, p.1397-1401, 1997.
KEYSTONE, E.C. et al. Zymosan-induced arthritis: a model of chronic proliferative arthritis following activation of the alternative pathway of complement. Arthritis Rheum.v.20, p.1396-1401, 1989.
KLOAREG, B.; QUATRANO, R. S. Structure of cell wall of marine algae and
ecophysiological function of matrix polysaccharides. Oceanogr. Mar. Biol. Ann. Ver., v. 26; p. 259-315, 1988.
KYLIN, H. Biochemistry of sea algae. Z. Physiol. Chem., v. 83, p. 171-197, 1913.
KONNO, S. TSURUFUJI, S. Analysis of the factors involved in pathogenesis of zymosan induced inflammation in rats. Japan J Pharmacol. V.38, p.117-184, 1985.
LASKY, L. A. Selectin-carbohydrate interactions and the initiation of the inflammatory response.Annu. ver. Biochem., v.64, p.113-139, 1995.
LANGMAN, M. J. et al.Risks of bleeding peptic ulcer associated with individual non- steroidal anti-inflammatory drugs. Lancet. V.343, p. 1075-1078, 1994.
LAURENT, T.C. et al. Hyaluronan in inflammatory joint disease. Acta Orthop Scand, v.266, p.116-120, 1995.
LEITE, E. L.et al. Structure of a new fucan from the algae Spatoglossum schröederi. Plant Science, v.132, p. 215-228, 1998.
LOGEART, D. et al. Fucans, sulphated polysaccharides extracted from brown
seaweeds, inhibit vascular smooth muscle cell proliferation. I. Comparison with heparin for antiproliferative activity, binding and internalization. Eur. J. Cell Biol., v. 74, p. 376- 384, 1997.
MCCAFFREY, A. T. et al. Fucoidans is a non-anticoagulant inhibitor of intimal hyperplasia. Bioch. Biophy. Res. Comm., v. 184, n.2, 773-781, 1996.
MICHELACCI, Y. M.; LAREDO, J.; DIETRICH, C. P. Proteoglycans and chondroitin sulfates from human multiple chondroma (Enchondromatosis). Braz. J. Med. Biol. Res. v.14, p.161-172, 1981.
MOLLACE, V. et al. Modulation of prostagalndin biosynthesis by nitric oxide and nitric oxide donors. Pharmacol. Reviews. V.57, p.217-252, 2005.
MORELAND, L.W. Inhibitors of tumor necrosis factor: new treatment options for rheumatoid arthritis. Clev. Clin. J. Med. V.66, p.367-374, 1999.
MORY, H.; NISIZIWA, K. – Sugar constituents of sulfated polysaccharides from the fronds of Sargassum ringgoldianum. Bull. Jap. Soc. Sci. Fish., v. 48, p. 981-986, 1982.
MOURÃO, P.A.S. et al. Structure and anticoagulant activity of a fucosylated chondroitin sulfate form echinoderm. J. Biol. Chem., v. 271, p. 23973-23984, 1996.
MULLOY B.; MOURÃO P.A.S.; GRAY E. Structure/function studies of anticoagulant sulphated polysaccharides using NMR. J. of Biotechnol., v. 77, p. 123-135, 2000.
NAGAOKA, M.et al. Structural study of fucoidan from Cladosiphon okamuranus Tokida. Glycoconjugate J., v.16, p. 19-26, 1999.
NANTEL, F. et al, Immunolocalization of COX-2 in the macula densa of human elderly. FEBS Lett. V.457, p.475-477, 1999.
NARDELLA, A. et al. Anticoagulant low molecular weights fucans produced by radical process and ion exchange chromatography of high molecular weights fucans extracted from brown seaweed Ascophyllum nodosum. Carbohyd. Res., v. 289, p. 201-208, 1996.
NISHINO, T.et al. An anticoagulant fucoidan from brown seaweed Ecklonia kurome. Phytochemistry, v. 30, 535-539, 1991.
NISHINO, T. et al. Inhibition of the generation of thrombin and factor Xa by a fucoidan from the brown seaweed Ecklonia kurome. Thromb. Res., v. 96, p. 37-49, 1999.
NISHINO, T. et al. Effects of a fucoidan on the activation of plasminogen by u-PA and t- PA. Thomb. Res., v. 99, p. 623-634, 2000.
OLIVER, S.J.; BRAHN, E. Combination therapy in rheumatoid arthritis: the animal model perspective. J. Rheum.v. 23, p. 56-60, 1996.
OSTERGAARD, C. et al. Inibition of leukocyte entry into the brian by the selectin blocker fucoidin decreases interleukin-1 (IL-1) leves but increases IL-8 levels in cerebrospinal fuild during experimental pneumococcal meningitidis in rabbits. Infect Immun. V.68, p.3153-3157, 2000.
PATANKAR, M. S. et al. A revised structure for fucoidan may explain some of its biological activities. J. Biol. Chem., v. 268, p.21770-21770, 1993.
PANDO, J. A. et al. Synovitis occurs in some clinically normal and asymptomatic joints in patients with early arthritis. Journal of Rheumatology. V.27, p.1848-1854, 2000.
PAP, T. et al. Fibroblast biology: role of fibroblast in the pathogenesis of rheumatoid arthritis. Arthritis Research. V.2, p.361-367, 2000.
PELLETIER, J. P. et al. Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors. J. Rheumatol. V.26, p.2002-2014, 1999.
PETTIPHER, E. R. et al. Cartilage proteoglycan depletion in acute and chronic antigen- induced arthritis. Arthritis Rheum. v. 32. p. 601-607, 1989.
PERCIVAL, E.G. V.; MC DOWELL, R. H. Chemistry and enzymology of marine algal polysaccharides. London: Academic Press, 219, 1967.
RAMOS, A. M. O. et al. Artrite induzida por zymosan em ratos: estudo histopatológico, histoquímico e bioquímico dos glicoconjugados da cartilagem articular. Rev. Bras. Reumatol. V.41, n.4, p.205-212, 2001.
ROCHA, F. A.C. et al. PAF modulates eicosanoid and TNF release in imune complex arthritis in rats. J. lipid. Mediat. Cell Signal., v.16, p.1-10, 1997.
ROCHA, F.A.C. et al. Periarthritis promotes gait disturbance in zymosan-induced arthritis in rats. Inflamm. Res. V.48, p.485-490, 1999.
ROCHA, F. A.C. et al. Efeito de inibidores da sintase de óxido nítrico na dor inflamatória articular e influxo celular da artrite induzida por zymosan em ratos. Rev. Bras.
Reumatol. V.43, p.206-217, 2003.
ROCHA, H. A. O. et al. Structural and haemostatic activities of a sulfated galactofucan from the brown alga spatoglossum schroederi. An ideal antithrombotic agent? J. Biol. Chem. V.10, p.1-14, 2005.
ROTH, G.J.; STANFORD, N.; MAJERUS, P.W. Acetylation of prostaglandin synthase by aspirin. Proc. Natl.Acad. Sci. USA, v.72, p.3073-3076, 1975.
SANTOS, M. G. L. Propriedades imunomoduladoras das fucoidanas Purificadas de Fucus vesiculosus. Natal, RN, Brasil, 2004.(Dissertação-Mestrado, Universidade Federal do Rio Grande do Norte).
SCHWARTZ, R.S. Autoimmunity and Autoimmune Diseases. Fundamental Immunology, third edition, p. 1033-1097, chapter 30, New York, 1993.
SCHAEFFER, D.et al. Anti- HIV activity of extracts compouds from algae and cyanobacteria. Ecotoxicology and Environmental., P.208-227,2000.
SODEN, M. et al. Immunohistological features in the synovium obtained from clinically uninvolved knee joints of patients with rheumatoid arthritis. British Journal of
Rheumatology. V.28, p.287-292, 1989.
SOEDA, S. et al. Fibrinolytic and anticoagulant activities of highly sulfated fucoidan. Biochem. Pharmacol., v. 43, p.1853-1858, 1992.
SOEDA, S. et al. Oversulfated fucoidan inhibits the basic fibroblast growth factor- induced tube formation by human umbilical vein endothelial cells: its possible mechanism of action. Biochem. Biophy. Acta., v.1497, p. 127-134, 2000.
SMITH, J.B.; HAYNES, M.K. Rheumatoid arthritis: a molecular understanding. Ann Intern Med. V.236; p. 908-922, 2002.
SZABÓ, T. et al. Biochemical properties of the ligand-binding 20-Kda subunit of the E- glucan receptors on human mononuclear phagocytes. The Journal of Biological Chemistry. V. 270, n.5. p.2145-2151 February 3, 1995.
TARNER, I.H. et al. The different stages of synovitis: acute vs chronic, early vs late and non-erosive vs erosive. Best Practice & Research Clinical Rheumatology. V.19, N.01, p. 19-35, 2005.
TAYLON, P. R. et al. The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J. Immunol. V.169, p.3876-3882, 2002.
TEIXEIRA, M.M.; HELLEWELL, P. The effect of the selectin binding polysaccharide fucoidin on eosinophil recruitment in vivo. Brit. J. Pharmacol., v.120, p.1059-1066, 1997.
VAN DER HEIJDE, D.M. et al. Bianual radiographic assessments of hands and feet in a three-year prospective followup of patients with early rheumatoid arthritis. Arthritis Rheum. V.35, p.26-34, 1992.
VERDRENGH, M. et al. Role of selectins in experimental Staphylococcus aureus- induced arthritis, Eur. J. Immunol., V.30, p.1606-1613, 2000.
WHELTON, A. et al. Cox-2specific inhibitors and cardiorenal function: a randomized, controlled trial of celecoxib and rofecoxib in older hypertensive osteoarthritis patients. Am. J. Ther. V.8, p.85-95, 2001.
WILLIAMS, S.J.; DAVIES, G.J. Protein-carbohydrate interactions: learning lessons from nature. Trends in Biotechnology, v.19, n.9, p.356-362, 2001.
WILLMENT, J. A. et al. Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by Il 10, dexamethasone, and lipopolysaccharide. Journal of Immunology. V. 171, p.4569- 4573, 2003.
YAMAMOTO, I.; SUZUKI, Y.; UMEZAWA, I. Antitumor effect of seaweed. Partial
purification and the antitumor effect of polysaccharides from Laminaria augusta Kjellman var. longissima Miyabe. Chemotherapy, v. 28; p. 165-170, 1980.
YAMAMOTO, I. et al. Antitumor activity of crude extracts from edible marine algae against L-1210 leukemia. Bot. Mar., v. 25, p. 455-457, 1982.
ZEIDLER, H. W. et al. Progression of joint damage in early active severe rheumatoid artritis during 18 months of treatment: comparison of low-dose cyclosporine and parental gold. Br. J. Rheumatol. V.37, p.874-882, 1998.
ZHUANG, C. et al. Antitumor active fucoidan from brown seaweed, Umitorano (Sargassum thumbergii). Biosci. Biotech. Biochem., v. 59, n. 4, p. 563-567, 1995.