I. BÖLÜM
1. Mali Denetim
2.2. Gider Bütçesi
Os dados de estrutura primária obtidos nessa tese irão subsidiar estudos futuros, como a expressão da lectina recombinante e desta forma possibilitar estudos estruturais como Cristalografia de raios X assim obtendo a estrutura tridimensional da lectina o que subsidiará estudos relacionando estrutura-função da AML e suas aplicações.
Mais investigações sobre a toxicidade da AML contra células não doentes são necessárias para complementar os resultados obtidos nessa tese com relação ao potencial anticâncer da AML.
74
REFERÊNCIAS
ABREU, T. M.; RIBEIRO, N. A.; CHAVES, H. V.; JORGE, R. J.; BEZERRA, M. M.; MONTEIRO, H. S.; VASCONCELOS, I. M.; MOTA, É. F.; BENEVIDES, N. M. Antinociceptive and Anti-inflammatory Activities of the Lectin from Marine Red Alga Solieria filiformis Planta Med.. doi: 10.1055/s-0042-101762. v. 82, n. 7, p.596-605. April 2016.
ADHYA, M.; SINGHA B.; CHATTERJEE, B. P. Purification and characterization of an Nacetylglucosamine specific lectin from marine bivalve Macoma birmanica Fish & Shellfish Immunology v. 27, p. 1–8, 2009.
AINOUZ, I. L; SAMPAIO A.H.; FREITAS A.L.P.; BENEVIDES N.M.B.; MAPURUNGA S. Comparative study on hemagglutinins from the red algae Bryothamnion seaforthii and Bryothamnion triquetrum. Revista Brasileira de Fisiologia Vegetal v. 7, p. 15– 19, 1995. AINOUZ, I. L.; SAMPAIO, A. H. Screening of Brazilian marine algae for
hemaglutinins.Botanica Marina, Berlin, v. 34, n. 3, p. 211 - 214, May 1991.
AINOUZ, I. L.; SAMPAIO A. H.; FREITAS, A. L. P.; BENEVIDES, N. M. B.;
MAPURUNGA, S. Comparative study on hemagglutinins from the red algae Bryothamnion seaforthii and Bryothamnion triquetrum. Revista Brasileira de Fisiologia Vegetal v. 7, p. 15 – 19, 1995.
AIRANTHI, M. K. W. A.; HOSOKAWA, M.; MIYASHITA, K. Comparative antioxidant activity of edible Japanese brown seaweeds. Journal Food Science v. 76, p. 104-111, 2011.
AKKOUH, O.; NG, T. B.; SINGH, S. S.; YIN, C.; DAN, X.; CHAN, Y. S.; PAN, W.; CHEUNG, R, C. F. Lectins with Anti-HIV Activity: A Review. Molecules doi:10.3390/molecules20010648 v. 20, p. 648-668, 2015.
ALENCAR, D. B.; SILVA. S. R.; PIRES-CAVALCANTE, K. M. S.; LIMA, R. L.; PEREIRA –JÚNIOR, F. N.; SOUSA, M. B.; VIANA, F. A.; NAGANO, C. S.; NASCIMENTO, K. S.; CAVADA, B. S.; SAMPAIO, A. H.; SAKER-SAMPAIO S. Antioxidant potential and cytotoxic activity of two red seaweed species, Amansia multifida and Meristiella echinocarpa, from the coast of Northeastern Brazil. Anais da academia brasileira de ciências v. 86, n. 1, p. 251- 263, 2014.
ALEXANDRE, K., B.; GRAY, E. S.; LAMBSON, B. E.; MOORE, P. L.; CHOGE, I. A.; MLISANA, K.; KARIN, S. S. A; MCMAHON, J.; O’KEEFE, B.; CHIKWAMBA, R.; MORRIS, L. Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectinsm Griffithsin, Cyanovirin-N and Scytovirin Virology Africa v. 402, p. 187-196, April 2010.
ALEXANDRE, K., B.; GRAY, E. S.; MUFHANDU, H.; MCMAHON, J. B.; CHAKAUYA E.; O’KEEFE, B.; CHIKWAMBA, R.; MORRIS, L. the lectins griffithsin, cyanovirin-N and Scytovirin inhibit HIV-1 binding to the DC-SING receptor and transfer to CD4+ cells Virology Africa v. 423, p. 175-186, January 2012.
75
ALGABASE. Listing the world’s algae. Disponível em: < http//:www.alagebase.org> Acesso em: 15 de março de 2016.
AMBROSIO A. L.; SANZ L.; SÁNCHEZ E. I.; WOLFENSTEIN-TODEL C.; CALVETE J. J. Isolation of two novel mannan- and l-fucose-binding lectins from the green
alga Enteromorpha prolifera: biochemical characterization of EPL-2.Archives of Biochemistry and Biophysics v. 415, Issue 2, pag. 245–250, 2003.
ANDRADE, L. N.; AMARAL, R. G.; DÓRIA, G. A. A.; FONSECA, C. S.; SILVA, T. K. M.; ALBUQUERQUE-JÚNIOR, R. L. C.; THOMAZZI, S. M.; NASCIMENTO, L. G.; CARVALHO, A. A.; SOUSA, D. P. In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol International Journal Molecular Science v. 17, n. 32, p. 1 -11; doi:10.3390/ijms17010032 january 2016. BAGYA S. K.; RAJASHREE, P. V.; SAM, K. G. Preliminary anticancer screening and standardization of some indigenous medicinal plants using cell-biology and molecular biotechnology based models. Res J Med Plant v. 5, p.728-737, 2011.
BALZARINI, J. Large-molecular-weight carbohydrate-binding agents as HIV entry inhibitors targeting glycoprotein gp120. Current Opinion HIV AIDS, v.1, n.5, p.355–360, 2006. BALZARINI, J.; VAN LAETHEM, K.; HATSE, S.; FROEYEN, M.; PEUMANS, W.; VAN DAMME, E.; SCHOLS, D. Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV gp120: A new therapeutic concept to hit the achilles heel of HIV. Journal of Biological Chemistry. v. 280, n. 49, p. 41005–41014, 2005.
BALZARINI, J.; VAN LAETHEM, K.; PEUMANS, W. J.; VAN DAMME, E. J. M.; BOLMSTEDT, A.; GAGO, F.; SCHOLS, D. Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N- glycan deletions in their gp120 envelopes. Journal of Virology. v.80, n. 17, p. 8411–8421, 2006.
BARRIENTOS, L. G.; O’KEEFE, B. R.; BRAY, M., SANCHEZ, A.; GRONENBORN, A. M.; BOYD, M. R. Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus Antiviral Res. v. 58, p. 47–56, 2003.
BENEVIDES, N. M. B.; LEITE, A. M.; FREITAS, A. L. P. Atividade hemaglutinante na alga vermelha Solieria filiformis. Revista Brasileira de Fisiologia Vegetal. v. 8, p. 117 - 122, 1996.
BITENCOURT, F. D.; FIGUEIREDO, J. G.; MOTA, M. R.; BEZERRA. C. C.; SILVESTRE P.P.; VALE, M. R.; NASCIMENTO, K. S.; SAMPAIO, A. H.; NAGANO, C. S.; SAKER- SAMPAIO. S.; FARIAS, W. R.; CAVADA, B. S., ASSREUY, A. M.; DE ALENCAR, N. M.; Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis. Naunyn-Schmiedeberg's Archives of Pharmacology, v. 377, p. 139-148, 2008.
BLOIS, M. S. antioxidant determination by the use of a stable free radical. Nature, London, v. 181, n. 4617, p. 1199-1200, 1958.
76
BOISVERT, C.; BEAULIEU, L., BONNET, C.; PELLETIER, E. Assessment of the antioxidante and antibacterial activities of three species of edible seaweeds. Jouornal of Biochemistry, Quebec, v. 39, n. 4, p. 377-387, Augst 2015.
BOKESCH, H. R; O'KEEFE, B.R.; MCKEE, T.C.; PANNELL, L.K.; PATTERSON, G. M.; GARDELLA, R.S.; SOWDER, R.C.; TURPIN, J.; WATSON, K.; BUCKHEIT JR, R.W. et al. A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Biochemistry. v. 42, n. 9, p. 2578–2584, 2003.
BOTOS, I.; WLODAWER, A. Proteins that bind high-mannose sugars of the HIV envelope. Prog Biophys Mol Biol. v. 2, p. 233-82. 2005.
BOYD, W. C.; ALMODÓVAR, L.R.; BOYD, L.G. Agglutinin in marine algae for human erythrocytes. Comparative Biochemistry and Physiology, v.6, p.82-83, 1966.
BUCKHEIT, R.W. JR.; WATSON, K. M.; MORROW, K. M.; HAM, A. S. Development of topical microbicides to prevent the sexual transmission of HIV. Antiviral Research v. 85, p. 142–158, 2010.
CALVETE, J. J.; COSTA, F. H.; SAKER-SAMPAIO, S.; MURCIANO, M P; NAGANO, C. S.; CAVADA, B. S; GRANGEIRO, T. B.; RAMOS M.V.; BLOCH C.; SILVEIRA, S. B.; FREITAS, B. T.; SAMPAIO A. H.. The amino acid sequence of the agglutinin isolated from the red marinealga Bryothamnion triquetrum defines a novel lectin structure. CMLS Cellular and Molecular Life Sciences. v. 57, p. 343 – 350, 2000.
CARDOZO, K. H.; GUARATINI, T.; BARROS, M. P.; FALCÃO, V. R.; TONON, A. P.; LOPES, N. P.; CAMPOS, S.; TORRES, M. A.; SOUZA, A. O.; COLEPICOLO, P.; PINTO, E. Metabolites from algae with economic impact. Comparative Biochemistry and
Physiology Part C: Toxicology Pharmacology. v. 146, p. 60 - 78, 2007. CARNEIRO R.F.; MELO, A. A.; NASCIMENTO, F. E. P.; SIMPLICIO, C. A.; NASCIMENTO, K. S.; ROCHA, B. A. M.; SAKER-SAMPAIO, S.; MOURA, R. M.; MOTA, S. S.; CAVADA, B. S.; NAGANO, C. S.; SAMPAIO, A. H. Halilectin 1 (H-1) and Halilectin 2 (H-2): two new lectins isolated from the marine sponge Haliclona caerulea Journal of Molecular Recognition v.26, I. 1, p. 51–58, January 2013.
CAVALCANTE, T. T. A.; FIRMINO, N. S.; TAJRA, F. S.; ANDRADE, C. R.; COSTA, R. A. Plant lectins as alternative tools against bacterial biofilms. African Journal of
Microbiology Research, v. 8, n. 27, p. 2555-2564, July, 2014.
CHAKRABORTY, K.; JOSEPH, D.; PRAVEEN, N. K. Antioxidant activities and phenolic contents of three red seaeeds (Division: Rhodophyta) harvested from Gulf of Mannarof
Penisular India. Journal of Food Science and Technology-Mysore, New Delhi, v. 52, n.4, p. 1924-1935, April 2015.
CHAVES R. P. ESTRUTURA PRIMARIA DE DUAS ISOLECTINAS DA ALGA MARINHA VERMELHA Solieria filiformis (Kützing) P.W.Gabrielson. (2013).
Dissertação de mestrado (Mestrado em Engenharia de Pesca) - Centro de Ciências Agrárias, Universidade Federal do Ceará, Fortaleza, 2013.
77
CHEUNG, R. C.; WONG, J. H.; PAN, W.; CHAN, Y.S.; YIN, C.; DAN, X.; NG, T. B. Marine lectins and their medicinal applications. Applied Microbiology and Biotechnology, v. 99, n. 9, p. 3755-3773, May 2015.
CHEW, Y. L.; LIM, Y. Y.; OMAR, M.; KHOO, K. S. Antioxidant activity of three edible seaweeds from two áreas in South East Asia. LWT-Food Science and Technology, Amsterdam, v. 41, n. 6, p. 1067-1072, 2008.
CHO, M. L.; LEE, H. S.; KANG, I. J.; WON, M. H.; YOU, S. G. Antioxidant properties of extract and fractions from Enteromorpha prolifera, a type of green seaweed. Food Chemistry v. 127: p. 999-1006, 2011.
CHU, C. Y.; HUANG, R.; LING L. P. Purification and characterization of a novel
haemagglutinin from Chlorella pyrenoidosa. J Ind Microbiol Biotechnol. v. 33, n. 11, p. 967-973. Jun 2006.
CORNISH, M.L.; GARBARY, D.J. Antioxidants from macroalgae: Potential applications in human health and nutrition. Algae, Canadá, v. 25, p. 155–171, November 2010.
COSTA, F. H. F.; SAMPAIO, A. H.; NEVES, S. A.; ROCHA, M. L. A.; BENEVIDES, N. M. B.; FREITAS, A. L. P. Purification and characterization of a lectin from the red marine alga Amansia multifida. Physiology and Molecular Biology of Plants v.5, p.53-61, 1999.
COX, S.; ABU-GHANNAM, N; GUPTA, S. An assessment of the antioxidante and
antimicrobial activity of six species of edble Irish seaweeds. International Food Research Journal, Selangor, v. 17, n.1, p. 205-220, 2010.
DANTAS, N. P. et al., Biota Marinha da Costa Oeste do Ceará. In:MATTHEWS-CASCON, H.; LOTUFO, T. M. C. (Org.). Biota Marinha da Costa Oeste do Ceará. 1 ed. Brasília: Ministério do Meio Ambiente, v. 24, p. 7-70, 2006.
DELATORRE, P.; ROCHA, B. A. M.; SOUZA, E. P.; OLIVEIRA, T. M.; BEZERRA, G. A.; MORENO, F. B. M. B.; FREITAS, B. T.; SANTI-GADELHA, T.; SAMPAIO, A. H.;
AZEVEDOJR, W. F.; CAVADA B. S. Structure of a lectin from Canavalia gladiata seeds: new structural insights for old molecules BMC Structural Biology doi: 10.1186/1472-6807- 7-52 v. 7, n 52. August 2007.
DE PAULA, G. L. Análise estrutural mediante espectrometria de massa da lectina da alga marinha vermelha Gracilariopsis sjoestedtii. 2011, 48f. Monografia (Graduação no Curso de Engenharia de Pesca) - Centro de Ciências Agrárias, Departamento de Engenharia de Pesca, UFC, Fortaleza, 2011.
DEY, B.; LERNER, D. L.; LUSSO, P.; BOYD M. R.; ELDER, J. H.; BERGER, E. A.; Multiple Antiviral Activities of Cyanovirin-N: Blocking of Human Immunodeficiency Virus Type 1 gp120 Interaction with CD4 and Coreceptor and Inhibition of Diverse Enveloped Viruses Journal of virology, v.74, n.10, p. 4562–4569May 2000.
ELIAS, R. J.; KELLERBY, S. S.; DECKER, E. A., Antioxidant activity of proteins and peptides. Critical Reviews in Food Science and Nutrition. v. 48, p. 430-441, 2008.
78
ESTRADA, J. E. P.; P. BERMEJO B., A.M.; VILLAR, D. F. Antioxidant activity of different fractions of Spirulina platensis protean extract Il Farmaco v. 5 6, p. 4 9 7 – 500, 2001.
EWING, B.; GREEN P: Basecalling of automated sequencer traces using phred. II. Error probabilities. Genome Research v. 8, p. 186-194. 1998.
FABREGAS J.; MUÑOZ, A.; LLOVO, J.; CARRACEDO, A., Purification and partial characterization of tomentine. An N-acetylglucosamine-specific lectin from the green alga Codium tomentosum (Huds.) Stackh. Journal of Experimental Marine Biology and Ecology. v. 124, n. 1, Pag. 21–30, 1988.
FAO Food and Agriculture Organization of the United Nations Disponível em:
<http://www.fao.org/docrep/006/y4765e/y4765e0c.htm> Acessível em: 18 de Abil de 2016 às 17:22, 2016.
FERIR, G.; PALMER, K. E., SCHOLS, D. Griffithsin, Alone and Combined with All Classes of Antiretroviral Drugs, Potently Inhibits HIV Cell-Cell Transmission and Destruction of CD4+ T cells Journal Antivirals and Antiretrovirals v. 4, n.4, p.103-112, 2012.
FERIR, G.; BOUDREAUX, D. M.; SWANSON, M. D.; MARKOVITZ, D.M.; BALZARINI, J.; SCHOLS, D. Combinations of Griffithsin with Other Carbohydrate-Binding Agents
Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate- Binding Agent-Resistant HIV Type 1 Strains. Aids Research and Human Retroviruses. v. 28, n, 11, p. 1513-1523, 2012.
FÉRIR, G.; HUSKENS, D.; NOPPEN, S.; KOHARUDIN, L.M.; GRONENBORN, A.M.; SCHOLS, D. Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family. Journal Antimicrob. Chemother.v. 69, p. 2746–2758, 2014.
FERLAY, J.; SOERJOMATARAM, I.; DIKSHIT, R.; ESER, S.; MATHERS, C.; REBELO, M.; PARKIN, D.M.; FORMAN, D.; BRAY, F. Cancer incidence and mortality worldwide: Sources, methods and major patterns in Globocan 2012. Int. J.Cancer v. 136, p. 359–386, 2015.
FIGUEIREDO, J. G.; BITENCOURT F .S.; CUNHA T. M.; LUZ P. B.; NASCIMENTO K. S.; MOTA M. R. L.; SAMPAIO A.H., CAVADA B.S., CUNHA F.Q., ALENCAR N.M.N., Agglutinin isolated from the red marine alga Hypnea cervicornis J. Agardh reduces
inflammatory hypernociception: Involvement of nitric oxide. Pharmacology, Biochemistry and Behavior, p. 371-377, 2010.
FOUQUAERT, E.; HANTON, S. L.; BRANDIZZI, F.; PEUMANS, W.J.; VAN DAMME E. J. M. Localization and topogenesis studies of cytoplasmic and vacuolar homologs of the Galanthus nivalis agglutinin. Plant Cell Physiology doi: 10.1093/pcp/pcm071. v. 48. p. 1010–1021, 2007.
FRANÇOIS, K. O.; BALZARINI, J. Potential of Carbohydrate-Binding Agents as Therapeutics Against Enveloped Viruses Medicinal Research Reviews, Belgium v. 32, n. 2, p. 349-387, June 2012.
79
FUKUDA, Y.; SUGAHARA, T.; UENO, M.; FUKUTA, Y.; OCHI, Y.; AKIYAMA, K.; MIYAZAKI, T.; MASUDA, S.; KAWAKUBO, A.; KEIICHI K. The anti-tumor effect of Euchema serra agglutinin on colon cancer cells in vitro and in vivo Anti-Cancer Drugs v.17, n. 8, p. 943-947, 2006.
GABIUS, H. J.; GABIUS, S. Glycoscience: Status and Perspectives. Germany, 1997. GORDON, DAVID. "Viewing and Editing Assembled Sequences Using Consed", in Current Protocols in Bioinformatics,A. D. BAXEVANIS AND D. B. DAVISON, eds, New York: John Wiley & Co., doi.11.2.1-11.2.43. 2004.
GURNANI, N.; MEHTA, D.; GUPTA, M.; MEHTA, B.K. Natural Products: Source of Potential Drugs. Afr. J. Basic Appl. Sci. v. 6, p. 171–186, 2014.
HALLIWELL, B.; GUTTERIDGE, J. M. C. Free Radicals in Biology and Medicine fourth edition ISBN: 9780198568698, 704p. May 2007.
HALL M. R.; McGILLICUDDY, E.; KAPLAN, L. J.; Biofilm: basic principles,
pathophysiology, and implications for clinicians. Surgical Infections. v. 15, n. 1, p. 1–7, 2014.
HAMILOS, D. L. Host-microbial interactions in patients with chronic rhinosinusitis. Journal Allergy Clin Immunol. doi: 10.1016/j.jaci.2013.06.049. v. 133, n. 3, p. 640-653. November 2014.
HAN J. W.; YOON K. S.; JUNG M.G.; CHAH K.-H.; KIM G. H., Molecular characterization of a lectin, BPL-4, from the marine green alga Bryopsis plumosa (Chlorophyta) Algae, v. 27, n. 1, p. 55-62, 2012a.
HAN J. W.; YOON, K. S.; KLOCHKOVA, T. A. HWANG, M. S., KIM G. H. Purification and characterization of a lectin, BPL-3, from the marine green alga Bryopsis plumosa Journal Applied of Phycology, v.23, p. 745-753, 2011.
HAN J.W.; KLOCHKOVA T. A., SHIM J.B., YOON K., KIM G. H. Isolation and characterization of a sex-specific lectin in a marine red alga, Aglaothamnion oosumiense Itono. Applied Environment Microbiolology, v.78, n. 20, p. 7283-9, 2012b.
HARNEDY, P.; FITZGERALD R. J. Review of bioactive protein, peptide and amino acids from macroalgae. Journal of Phycology. v. 47, p. 281-232, 2011.
HIRAYAMA, M.; SHIBATA, H.; IMAMURA, K.; SAKAGUCHI, T.; HORI, K. High- Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120 Marine Biotechnology v. 18, p.144–160, 2016.
HORI K.; SATO Y.; ITO, K.; FUJIWARA, Y.; WAMOTOY. I.; MAKINO H.;
KAWAKUBO, A. Strict specificity for high-mannose type N-glycans and primary structureof a red alga Eucheuma serra lectin. Glycobiology. v. 17 n. 5 p. 479–491, 2007.
80
HORI, K., MATSUBARA, K., MIYASAWA, K. Primary structures of two hemaglutinins from marine red alga Hypnea japonica. Biochimica et Biophysica Acta, v. 1474, p. 226 – 236, 2000.
HORI, K.; MIYAZAWA, K.; LTO, K, Some common properties of lectins from marine algae. Hydrobiologia, v. 204/205, p. 561-566, 1990.
HYTONEN, J.; HAATAJA, S.; ISOMAKI, P.; FINNE, J. Identification of a novel glycoprotein-binding activity inStreptococcus pyogenes regulated by the mga gene. Microbiology v. 146, p. 31–39, 2000.
HULSMANS, M.; VAN DOOREN, E.; HOLVOET, P Mitochondrial reactive oxygen species and risk of atherosclerosis. Curr atheroscler rep v.14, n. 3, p. 264-276, 2012.
HUNG, L. D.; HIRAYAMA, M.; LY, B. M.; HORI, K. Purification, primary structure, and biological activity of the high-mannose N-glycan-specific lectin from cultivated Eucheuma denticulatum Journal of Applied Phycology v. 27, I. 4, p. 1657-1669, August 2015a. HUNG, L. D.; HIRAYAMA, M.; LY, B. M.; HORI, K. Biological activity, cDNA cloning and primary structure of lectin KSA-2 from the cultivated red alga Kappaphycus striatum (Schmitz) Doty ex Silva Phytochemistry Letters v. 14 p. 99–105, 2015b.
HUSKENS, D.; FÉRIR, G.; VERMEIRE, K.; KEHR, J.C.; BALZARINI, J.; DITTMANN, E.; SCHOLS, D. Microvirin, a novel alpha(1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile. Journal Biol Chem. doi: 10.1074/jbc.M110.128546 v. 285, n. 32, p. 24845- 24854, May 2010.
HUSKENS, D.; SCHOLS, D. Algal lectins as potential HIV microbicide candidates. Marine drugs Issn 1660-3397 v. 10 p. 1476 -1497, 2012.
HUSKENS, D.; VERMEIRE, K.; VANDEMEULEBROUCKE, E.; BALZARINI, J., SCHOLS, D. Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent. The International Journal of Biochemistry & Cell Biology Belgium v. 40, p. 2802- 2814, June 2008.
IMAI, K.; NAKAI, K. Prediction of subcellular locations of proteins: where to proceed? Proteomics. doi: 10.1002/pmic.201000274. v. 10, n. 22, p. 3970-3983, Nov. 2010.
IMAMICHI, Y.; YOKOYAMA, Y. Purification, characterization and cDNA cloning of a novel lectin from the jellyfish Nemopilema nomurai. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, v. 156, n. 1, p. 12-18, May. 2010.
ISHIHARA K.; ARAI S.; SHIMADA, S. cDNA cloning of a lectin-like gene preferentially expressed in freshwater from macroalga Ulva limnetica (ulcales, Chlorophyta).Phycological Research. v.57, p.104-110, 2009.
JE, J. Y.; PARK, P. J.; KIM, S. K. Antioxidant activity of a peptide isolated from Alaska pollack (Theragra chalcogramma) frame protein hydrolysate Food Research International v. 38, I. 1, p. 45-50, January 2005.
81
JI, J.;J. J-Y.; Braciale; V. B.; V. L., CLOYD, M. W. Apoptosis induced in HIV-exposed, resting CD4+T cellssubsequent to signaling through homing receptors is Fas/Fas ligand- mediated. Journal of Leukocyte Biology v. 1, p. 297-305. 2007.
KADAM, S. U.; TIWARI, B. K.; O’DONNELL, C. P. Application of Novel Extraction Technologies for Bioactives from Marine Algae Journal Agriculture Food Chemistry dx.doi.org/10.1021/jf400819p| v. 61, p. 4667−4675, 2013.
KARNATI, H.K.; YALAGALA, R.S.; UNDI, R.; PASUPULETI, S.R.; GUTTI, R.K. Therapeutic potential of siRNA and DNAzymes in cancer. Tumour Biol. v. 35, p. 9505– 9521, 2014.
KAWABATA, S.I.; IWANAGA, S. Role of lectins in the innate immunity of horseshoe crab. Dev. Comp. Immunol. v. 23, p. 391–400, 1999.
KAWAKUBO A.; MAKINO H.; OHNISHI J.; HIROHARA H.; HORI K. Occurrence of highly yielded lectins homologous within the genus Eucheuma. Journal Applied of Phycology v.11, p. 149-156, 1999.
KAWAKUBO, A.; MAKINO, H.; OHNISHI, J-I.; HIROHARA, H.; HORI, K. THE MARINE RED ALGA EUCHEUMA SERRA J. Agardh, a high yielding source of two isolectins. Journal of Applied Phycology, v. 9, p. 331–338, 1997.
KEHR, J. C.; ZILLIGES Y.; SPRINGER A.; DISNEY M. D.; RATNER D. D.; BOUCHIER C.; SEEBERGER P. H.; MARSAC N. T.; DITTMANN E. A mannan binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa. Molecular Microbiology. v. 59, n. 3, p. 893–906, 2006.
KOHARUDIN, L. M. I.; GRONENBORN, A. M. Antiviral lectins as potential HIV microbicides Current Opinion in Virology doi:10.1016/j.coviro.2014.05.006. 2014.
KOHARUDIN, L. M.; KOLLIPARA S, AIKEN C., GRONENBORN A.M. Structural Insights into the Anti-HIV Activity of the Oscillatoria agardhii Agglutinin Homolog Lectin Family. The Journal of Biological Chemistry, v. 287, n. 40, p. 33796–33811, 2012. KOHARUDIN, L. M. I.; WILLIAM FUREY, W.; GRONENBORN, A. M. Novel Fold and Carbohydrate Specificity of the Potent Anti-HIV Cyanobacterial Lectin from Oscillatoria agardhii The Journal Of Biological Chemistry v. 286, n. 2, p. 1588 –1597, January, 2011. LAEMMLI, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, v. 227, p. 680–685, 1970.
LEE, J. C.; HOU, M. F.; HUANG, H. W.; CHANG, F. R.; YEH, C. C.; TANG, J. Y.; CHANG, H. W. Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties Cancer Cell International, Taiwan, v. 13, n. 55, p. 1-7, June 2013.
LEE, S.J.; YOOK, S.; YHEE, J.Y.; YOON, H.Y.; KIM, M.G.; KU, S.H.; KIM, S.H.; PARK, J.H.; JEONG, J.H.; KWON, I.C.; etal. Co-deliveryofVEGFandBcl-2dual-targeteds iRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo. J. Control. Release 2015.
82
LEITE Y. F. M. M.; SILVA, L.M.C.M.; AMORIM, R.C.D.N.; FREIRE, E.A.; DE MELO JORGE, D.M.; GRANGEIRO, T.B.; BENEVIDES, N.M.B., Purification of a lectin from the marine red alga Gracilaria ornate and its effect on the development of the cowpea weevil Callosobruchus maculatus (Coleoptera: Bruchidae) Biochimica et Biophysica Acta v. 1724,p. 137 – 145, April 2005.
LIAO, W. R.; LINJ, Y.; SHIEH, W. Y.; JENG, W. L.; HUANG, R.. Antibiotic activity of lectins from marine algae against marine vibrios. Journal of Industrial Microbiology and Biotechnology. v. 30, p. 433 – 439, 2003.
LIMA, H. C.; F. H. F.; SAMPAIO, A. H.; NEVES S. A.; N. M. B., TEIXEIRA, D. I. A., ROGERS, D. J., FREITAS, A. L. P. Induction and inhibition of human lymphocyte transformation by the lectin from the red marine alga Amansia multifida.. Journal of Applied Phycology, v. 10, p. 153–162, 1998.
LIMA, R. F.; CRIDLE, D.N.; SOARES, P.M.; RIBEIRO, S.P.; CAVADA, B.S.;
NASCIMENTO, K.S.; SAMPAIO, A.H.; ASSREUY, A.M. Bryothamnion seaforthii lectin relaxes vascular smooth muscle: involvement of endothelium and NO synthase. Protein & Peptide Letters, v. 17, p. 305–310, 2010.
LOPES, S. P.; AZEVEDO, N. F.; PEREIRA, M. O. “Microbiome in cystic fibrosis: shaping poly microbial interactions for advances inantibiotic therapy,”Critical Reviews in
Microbiology, 2014.
MAHALINGAM, A.; GEONNOTTI, A. R.; BALZARINI, J.; KISER, P. F. Activity and Safety of Synthetic Lectins Based on BenzoboroxoleFunctionalized Polymers for Inhibition of HIV Entry Molecular Pharmaceutics, Belgium, dx.doi.org/10.1021/mp2002957 v. 8, p. 2465–2475, August 2011.
MALTA, D. C.; MORAIS-NETO, O. L.; SILVA-JUNIOR, J. B. Presentation of the Strategic Action Plan for Coping with Chronic Diseases in Brazil from 2011 to 2022 doi:
10.5123/S1679-49742011000400002 Epidemiol. Serv. Saúde, v. 20, n. 4, p. 425-438,out-dez 2011.
MEDINA-RAMIREZ, G.; GIBBS, R. V.; CALVETE, J. J. Micro-heterogeneity and
molecular assembly of the haemagglutinins from the red algae Bryothamnion seaforthii and B. triquetrum from the Caribbean Sea European Journal of Phycology
doi.org/10.1080/09670260601012438, v. 42, p. 105-112, 2007.
MEULEMAN, P.; ALBECKA, A.; BELOUZARD, S.; VERCAUTEREN, K.; VERHOYE, L.; WYCHOWSKI, C.; LEROUX-ROELS, G.; PALMER, K. E.; DUBUISSON, J.
Griffithsin has antiviral activity against hepatitis C virus. Antimicrob.Agents Chemother. v.55, n.11, p. 5159-5167, 2011.
MESQUITA, J. X. caracterização estrutural e atividade hipoglicemiante da lectina da alga marinha vermelha Amansia multifida (2010) Dissertação de mestrado (Mestrado em Bioquimica) - Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2010.
83
MEULEMAN, P.; ALBECKA, A.; BELOUZARD, S.; VERCAUTEREN, K.; VERHOYE, L., WYCHOWSKI, C.; LEROUX-ROELS, G.; PALMER, K. E.; DUBUISSON,
J. Griffithsin has antiviral activity against hepatitis C virus. Antimicrob.Agents Chemother. v.55, n.11, p. 5159-5167, 2011.
MOHAMED, S.; HASHIM, S. N.; RAHMAN, H. A. Seaweeds: a sustainable functional food for complementary and alternative therapy. Trends Food Sci. Technol., v. 23, p. 83−89, 2012.
MOKAWA, Y.; MIYAZAKI, T.; WALDE, P.; AKIYAMA, K.; SUGAHARA, T.;
MASUDA, S.; INADA, A.; OHNISHI, Y.; SAEKI, T.; KATO, K. In vitro and in vivo anti- tumor effects of novel Span 80 vesicles containing immobilized Eucheuma serra agglutinin. Intenational Journal Pharmocology. v. 15, p. 157-167, 2010.
MORI, T. O’KEEFE B.R.; SOWDER R. C.; BRINGANS S.; GARDELLA R.; BERG S., COCHRAN P.; TURPIN J. A.; BUCKHEIT R. W. Jr, MCMAHON J. B.., BOYD M. R., isolation and characterization of griffithsin, a novel HIV-inactivating protein,from the red alga Griffithsia sp. Journal Biology et Chemical, v.280, n.10, p. 9345-9353, 2005.
MOURA, R. M.; QUEIROZ, A; FOOK, J; DIAS, A; MONTEIRO, N ; RIBEIRO, J ; MOURA, G ; MACEDO, L ; SANTOS, E ; SALES, M . CvL, a lectin from the marine sponge Cliona varians: Isolation, characterization and its effects on pathogenic bacteria and Leishmania promastigotes. Comparative Biochemistry and Physiology. A, Molecular & Integrative Physiology, v. 145, n.4, p. 517-523, 2006.
MURRAY, P. R.; ROSENTHAL, K. S.; PFALLER, M. A. MICROBIOLOGIA MÉDICA 7 edição ISBN 978-85-352-7106-5, 2014, 888p.
NAGANO, C. S.; DEBRAY H.; NASCIMENTO, K. S.; PINTO,V. P.T.; CAVADA, B. S.; SAKER-SAMPAIO, S.; FARIAS, W.R.L.; SAMPAIO, A. H.; CALVETE J. J.,HCA and HML isolated from the red marine algae Hypnea cervicornisand Hypnea musciformis define a novel lectin family. Protein Science v.14, n. 8, p.2167-2176, 2005.
NAGANO, C.S.; MORENO F.B.; BLOCH M.B., PRATES C.; CALVETE M. J.; SAKER- SAMPAIO, S.; FARIAS, W.R. L.; TAVARES, T. D.; NASCIMENTO, K. S.; GRANGEIRO, T. B.; CAVADA, B. S.; SAMPAIO, A. H. Purification and characterization of a new lectin from the red marine alga Hypnea musciformis. Protein Peptide Letters v.9, n.2, p. 159-166, 2002.
NAGANO, C.S.; SANZ, L.; CALVETE, J.J. Estudios estructurales de lectinas de algas y de Vegetales Superiores. Editorial Académica Española, 133 pp. 2011.
NANGIA-MAKKER, P.; CONKLIN, J.; HOGAN, V.; RAZ, A. Carbohydrate-binding proteins in cancer, and their ligands as therapeutic agents. Trends Mol Med. v. 8, p. 187-92, 2002.
NASCIMENTO, A. S. F. Lectinas recombinantes das algas marinhas vermelhas Hypnea musciformis (wulfen) J. V. Lamouroux e Bryothamnion triquetrum (S. G. Gmelim) M. Howe: produção heteróloga e caracterização bioqímica, Tese de Doutorado (Doutorado Co-tutela em Bioquímica) - Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 260p. 2014.
84
NASCIMENTO-NETO, L. G. O.; CARNEIRO R. F.; SILVA S. R.; SILVA, B. R., ARRUDA, F. V. S., CARNEIRO, V. A., NASCIMENTO, K. S., SAKER-SAMPAIO S.,SILVA, J.R.V. A., PORTO A. L. F., CAVADA B. S. , SAMPAIO A. H.,TEIXEIRA, E. H., NAGANO C. S.,Characterization of Isoforms of the Lectin Isolated from the Red Algae Bryothamnion seaforthii and Its Pro-Healing Effect Marine Drugs. v.10, n.9, p.1936–1954. 2012.
NELSON, D. L.; COX, M.M. Lehninger Príncipios de bioquímica. 4.ed. São Paulo: Sarver, 2006. 1157p.
NELSON D. R., CUMSKY M. G, ZUSMAN D. R. Localization of myxobacterial
hemagglutinin in the periplasmic space and on the cell surface of Myxococcus xanthus during developmental aggregation. Journal Biological Chemistry v.256, p.12589–12595, 1981.
NEVES, S.A.; FREITAS, A.L.P.; SOUZA, B.W.S.; ROCHA, M.L.A.; CORREIA, M.V.O.; SAMPAIO, D.A VIANA, S.B. Antinociceptive properties in mice of a lectin isolated from the marine alga Amansia multifida Lamouroux. Brazilian Journal of Medical and Biological Research v. 40, n. 1, p. 127 - 134, 2007.
NEVES, S.A. DIAS-BARUFF M., FREITAS A.L., ROQUE-BARREIRA M.C. Neutrophil migration induced in vivo and in vitro by marine algal lectins Inflammation Research v. 50, p. 486-490, 2001.
NGO, D. H.; WIJESEKARA, I.; VO, T. S.; TA, Q. V.; KIM, S. K. Marine food-derived funtional ingredients as potential antioxidants in food industry: An overview. Food Research International, Amsterdam, v. 44, n. 2, p. 523-529, March 2011.
NIU, J., WANG, G., LÜ; PENG, G., Characterization of a new lectin involved in the protoplast regeneration of Bryopsis hypnoides. Chinese Journal of Oceanology and Limnology v. 27, n 3, p. 502-512, 2009.
O’KEEFE, B. R., SMEE, D. F., TURPIN, J. A. SAUCEDO, C. J., GUSTAFSON, K. R., MORI, T., BLAKESLEE, D., BUCKHEIT, R., BOYD M. R. Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin Antimicrobial Agents And Chemotherapy, v. 47, n.8, p. 2518–2525, August 2003.
O’KEEFE, B.R.; VOJDANI, F.; BUFFA, V.; SHATTOCK, R.J.; MONTEFIORI, D.C.; BAKKE, J.; MIRSALIS, J.; D’ANDREA, A.L.; HUME, S.D.; BRATCHER, B.; et al. Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component. Proc. Natl. Acad. Sci., v. 106, p. 6099–6104. USA 2009.
OKINO, N., KAWABATA, S., SAITO, T., HIRATA, M., TAKAGI, T., IWANAGA, S. Purification, characterization, and cDNA cloning of a 27-kDa lectin _L10.from horseshoe crab hemocytes. J.Biol. Chem.v. 270, p.31008–31015, 1995.
O’SULLIVAN, A. M.; O’CALLAGHAN, Y. C.; O’GRADY, M. N.; QUEGUINEUR, B.; HANNIFFY, D.; TROY, D. J.; KERRY, J. P.; O’BRIEN, N. M. In vitro and cellular antioxidante activities of seaweed extracts prepared from five brown seaweeds harvested in
85
spring from the West coast of Ireland. Food Chemistry, Oxford, v. 126, n. 3, p. 1064-1070,