Tuberk Toraks 2014;62(4):324
QuantiFERON-TB Gold In-Tube Test vs Tuberculin Skin Test
324
RE FE REN CES
1. Metin Timur Ö, Tanir G, Öz FN, Bayhan Gİ, Aydin Teke T, Tuygun N. Comparison of QuantiFERON-TB gold in-tube test with tuberculin skin test in children who had no contact with active tuberculosis case. Tuberk Toraks 2014;62:116- 21.
2. Wiwanitkit V. Field QuantiFERON-TB gold test. Am J Infect Control 2011;39:447.
3. Wiwanitkit V. QuantiFERON-TB gold test versus tuberculin skin test. Ann Thorac Med 2010;5:119.
4. Verhagen LM, Maes M, Villalba JA, d'Alessandro A, Rodriguez LP, España MF, et al. Agreement between QuantiFERON®-TB Gold In-Tube and the tuberculin skin test and predictors of positive test results in Warao Amerindian pediatric tuberculosis contacts. BMC Infect Dis 2014;14:383.
5. Rutherford ME, Nataprawira M, Yulita I, Apriani L, Maharani W, van Crevel R, et al. QuantiFERON®-TB Gold In-Tube assay vs. tuberculin skin test in Indonesian children living with a tuberculosis case. Int J Tuberc Lung Dis 2012;16:496- 502.
QuantiFERON-TB gold in-tube test vs. tuberculin skin test
doi • 10.5578/tt.8279 Tuberk Toraks 2014;62(4):324
Geliş Tarihi/Received: 09.09.2014 • Kabul Ediliş Tarihi/Accepted: 16.09.2014
EDİTÖRE MEKTUP LETTER TO THE EDITOR
Sim Sai TIN1
Viroj WIWANITKIT2
1 Shantou Medical Center, Shantou, China 1 Shantou Tıp Merkezi, Shantou, Çin
2 Department of Tropical Medicine, Faculty of Medicine, Hainan University, Hakou, China
2 Hainan Üniversitesi Tıp Fakültesi, Tropikal Hastalıklar, Hakou, Çin
Dr. Sim Sai TIN
Shantou Tıp Merkezi, SHANTOU - CHINA e-mail: simsaitin@gmail.com
Yazışma Adresi (Address for Correspondence) We would like to discuss on the publication on
“QuantiFERON-TB gold in-tube test with tuberculin skin test (1).” Metin Timur et al. concluded that “as a result of the study it is suggested to confirm positive TST results with tests based on interferon-gamma (IFN-γ) because it can reduce false positive diagnosis and treatment of latent tuberculosis infection (1). ”In fact, QuantiFERON-TB gold in-tube test is the new test that is widely mentioned for its usefulness (2,3).
However, it should be noted that the QuantiFERON- TB gold in-tube test is not exactly superior to standard tuberculin skin test. According to a report by Verhagen et al., it was noted that “replacement of TST by the QFT-GIT for detection of Mycobacterium tuberculosis infection is not recommended in this resource-constrained setting as test results showed substantial concordance and TST positivity was not affected by previous BCG vaccination (4).” Rutherford et al. also noted that “QFT-GIT offers little advantage over the TST (5)”.
CONFLICT of INTEREST None declared.
