Clinical Comparison of Aglepristone and Aglepristone+Prostaglandin
Administrations in Termination of Feline Midterm Pregnancy
Gizem TEZ, Simge YAZAN
Ankara University, Faculty of Veterinary Medicine
Unwanted preganancy in the cat
•
Unwanted kitten•
Age of the queen (Too young, too old)•
Health problems (Diabetes, problems of locomotor or cardiologic systems•
Matings with undesirable tomcat•
Population controlUnwanted preganancy in the cat
3
Ortalama Prevalans
Termination of Unwanted pregnancy in the queen
Ovariohysterectomy
Estrogens
Prostaglandins
Dopamine Agonists
Prostaglandin + Dopamine Agonist Combinations
Glucocorticoids
Progesterone Antagonists
5 GİZEM TEZ
Alizine (Aglepristone)
Sterile oily solution containing 30 mg/ml aglepristone
Used by subcutaneous injection
Queens at days 25-45 of pregnancy are injected with aglepristone 10 mg/kg subcutaneously twice, 24 h apart and abortion/rezorption is followed.
Alizine ( Aglepristone)
A progesterone antagonist interferes with progesterone metabolism in the uterus by blocking of the progesterone receptor and causes abortion.
Antiprogestins are synthetic steroids which bind with great
affinity to progesterone receptors without any of the effects of progesterone.
7 GİZEM TEZ
Prostaglandin
Prostaglandins, known as tissue hormones, are a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body
GİZEM TEZ 9
PGF2α supresses rrogesterone synthesis by activating protein kinase-C. Protein kinase-C induces Ca++ influx to corpora lutea and luteal apoptosis resulting in reduction in progesterone synthesis.
In addition, affecting smooth muscle cells, PGF2α results in uterine contractions and cervical dilatation.
Due to these effects; PGF2α is used in termination of pregnancy in the queen after days 25-30.
Prostaglandin (PG)
Prostaglangin dose in cats is 5 µg/kg.
Side effects are due to negative effects on smooth muscle cells and include; vomiting, hypersalivation, diarrhea, hyperpnea, ataxia, urination, anxiety, pupillary dilatation followed by construction. Reactions have sudden onset usually within 20-60 minutes of administration.
Prostaglandin (PG)
We proposed that addition of prostaglandin administration to common aglepristone protocol in termination of midterm pregnancy in cats might be useful by both increasing the efficiency of the protocol and decreasing the incidence of uterine infections caused by placental retention and ongoing luteal function.
11 GİZEM TEZ
Aim of the study
Materials and Method
A total of 24 mature (aged 1-4 years) queens of different breeds, introduced to the Clinic of Obstetrics and Gynecology Faculty of Veterinary Medicine University of Ankara, because of mismating was included into the study.
This study was confirmed by Ankara University Animal Experiments Local Ethics Committee.
Also this study was financed with Ankara University Scientific Research Projects Office as a Student-Oriented Research Project Support.
13 GİZEM TEZ
Determination of Gestation Day
Pregnancy diagnosis and determination of gestation day was performed by ultrasonography (Pie Medical Falcon 100, 5Mhz) according to Zambelli et al., (2002).
Ultrasonography
GİZEM TEZ 15
Study groups
17 GİZEM TEZ
Days 1 2 3 4 5 6 7
Group 1 (AGL)
AGL + USG
AGL + USG
USG USG USG USG USG
Group 2 (AGL + PG)
AGL + USG
AGL + USG
PG + USG
USG USG USG USG
Days 1 2 3 4 5 6 7 8 Group 1
(AGL) (n=12)
AGL + USG
AGL + USG
USG USG USG USG USG USG
Group 2 (AGL+PG)
(n=12)
AGL + USG
AGL + USG
PG + USG
USG USG USG USG USG
Results
Results
Results of the study shows
that we propose that addition of a single prostaglandin
administration to common aglepristone protocol in termination of midterm
pregnancy in cats shortens the duration of pregnancy
termination.
19 GİZEM TEZ
References
Baan, M., Taverne, M.A.M., Kooistra, H.S., De Gier, J., Dieleman, S.J., Okkens, A.C. (2005). Induction of parturition in the bitch with the progesterone-receptor blocker aglepristone. Theriogenology, 63: 1958-1972.
Bhatti, S.F., Duchateau, L., Okkens, A.C., Van Ham, L.M. , Mol, J.A., Kooistra, H.S. (2006). Treatment of growth hormone excess in dogs with the progesterone receptor antagonist aglepristone. Theriogenology, 66: 797-803.
Fieni F, Martal J, Marnet PG, Siliart B, Guittot F. (2006). Clinical, biological and hormonal study of mid-pregnancy termination in cats with aglepristone. Theriogenology. Oct;66(6-7):1721-1728.
Georgiev P, Wehrend A. (2006). Mid-gestation pregnancy termination by the progesterone antagonist aglepristone in queens.
Theriogenology. Apr 15;65(7):1401-1406.
Gobello, C. (2006). Dopamine agonists, anti-progestins, anti-androgens, long-term-release GnRH agonists and anti-estrogens in canine reproduction: A review. Theriogenology, 66: 1560-1567.
JOHNSTON, S.D., KUSTRITZ, V.R., OLSON, P.N.S. (2001). Precvention and termination of canine pregnancy. In: Canine and Feline Theriogenology., Philedelphia, WB SaundersCompany, p.:168-192
